Trials & guidelines

Question 1

TRICC Study

Answer 1

Transfusion Requirements in Critical Care - Multi Centre RCT
Liberal vs restrictive blood transfusion (100g/l vs 70g/l

Fewer transfusions in restrictive group (obviously)
Trend towards decreased mortality in the restrictive group
Performed before leukodepletion of blood products so mortality in liberal group might be lower if done today.

Question 2

TRISS

Answer 2

Transfusion requirement in Septic Shock - NEJM 2014

90g/l vs 70g/l in 2 arms
No significant difference in survival to 90 days

Question 3

ARISE

Answer 3

Australasian Resuscitation In Sepsis Evaluation

EGDT didn’t provide a reduction in mortality and trended towards an increase In organ support.

Question 4

PROPPR

Answer 4

Plasma:platelets:packed red cells ratio compared.

No mortality difference, but 1:1:1 achieved haemostasis and fewer died due to exsanguination in 24hrs.

Question 5

SHOT

Answer 5

Serious Hazards of Transfusion - 2013
1571 patients:

Acute transfusion reaction (ATR) - 320
Transfusion associated circulatory overload (TACO)- 96
Haemolytic transfusion reaction (HTR) - 49
Transfusion associated Acute Lung injury (TRALI) - 10
Transfusion Transmitted Infections (TTI) - <1