Trials

Question 1

Which trial showed: ARB in addition to ACEi some benefit in lowering BP and does reduce albuminuria further but increased risk hyperkalaemia and AKI with no evidence of reducing progression of CKD

Answer 1

ON-TARGET

VA NEPHRON-D

Question 2

Which trial showed: no evidence for stenting of RAS

Answer 2

ASTRAL, STAR, CORAL
medical mx just as good
small lowering BP but not clinically significant

Question 3

Which trial showed: no evidence for renal denervation

Answer 3

SIMPLICITY HTN-3

Question 4

Which trial showed: statin in CKD especially in the presence of diabetes to reduce CV events

Answer 4

SHARP
Note doesnt actually slow progression of CKD
Done in non dialysis diabetes and non diabetes CKD

4D and AURORA studies showed no survival benefit with dialysis patients (haemodialysis) on statin. One third SHARP patients were dialysis.

Question 5

Which trial showed: no benefit to early dialysis initiation if patient asymptomatic?

Answer 5

IDEAL Study

Question 6

Indications for starting dialysis?

Answer 6

Pericarditis
Uraemic symptoms
Fluid overload refractory to diuretics
Refractory or severe hyperkalaemia
Severe metabolic acidosis