Treatment of Hypertension Flashcards
RECAP: what is blood pressure and how is it regulated?
Blood pressure is the pressure exerted by the blood on the blood vessels.
Blood Pressure Regulation:
SHORT TERM: via neural systems, eg. baroreceptors
LONG TERM: via hormones and Na+ balance, eg. ECFV, degree of vasoconstriction
How can high blood pressure arise?
- an increase in ECFV
- an increase in vasoconstrictor agents
- a reduction in vasodilator agents
What are the two types of hypertension?
PRIMARY HYPERTENSION ( >90% of cases): has an unknown cause
SECONDARY HYPERTENSION (~10% of cases): has an identifiable cause
Some causes of hypertension:
- renal diseases (eg. glomerulonephritis, diabetic nephropathy)
- vascular causes (eg. renal artery stenosis)
- hormonal abnormalities (eg. Conn’s syndrome, Cushing’s syndrome, phaeochromocytoma)
- drugs (eg. contraceptive pill)
- pregnancy (eg. pre-eclampsia)
- monogenic genetic diseases (eg. Liddle’s)
Describe essential hypertension ( >90% of cases).
It has a prevalence in urban-based populations (~20%).
Genetic predisposition and environmental factors are proposed to cause essential hypertension through many mechanisms:
- increased sympathetic nervous system (SNS)
- increased renin-angiotensin-aldosterone system (RAAS)
- obesity/ insulin resistance
- endothelial dysfunction
- defects in vascular smooth muscle contraction
- defects in renal Na handling, increased salt intake
- age
- ethnicity (eg. it’s more common in Afro-Caribbean groups)
Why do we need to treat hypertension?
A reduction in blood pressure levels reduces the relative risk of consequences:
- a 5 mmHg drop in diastolic BP for 5 years
- reduces the chances of strokes by 42%
- reduces the chances of heart attacks by 16%
- reduces the vascular mortality by 21%
What are the goals of anti-hypertensive treatment?
The goals of anti-hypertensive treatment:
- adequate blood pressure control ( <140/90 mmHg), to alter the relative risk
- prevention of organ damage
- controlling other cardiovascular risk factors
What are the three main treatment pathways for hypertension?
- non-pharmacological (eg. lifestyle modifications)
- pharmacological treatment
- surgical treatment (eg. Conn’s Syndrome)
List some non-pharmacological treatments for hypertension (ie. lifestyle changes)?
- quit smoking (if applicable)
- weight control
- eat less salt
- regular exercise
- reduce alcohol intake
- behavioural therapies
List some pharmacological treatments for hypertension (ie.drugs)?
- major classes of antihypertensive drugs
- ACE inhibitors
- Angiotensin II receptor blockers
- diuretics
- drugs acting on the sympathetic nervous system
- vasodilators
What are some side effects of ACE inhibitors (caused by the decreased Angiotensin II effects)?
- cough (common) - due to bradykinin breakdown (con-compliance issue)
- angioedema (rare) - due to bradykinin breakdown (very serious, prevents breathing)
What are some side effects of ACE inhibitors and AT1 receptor blockers?
- hyperkalaemia (opposite to loop and thiazide diuretics) - this is due to decreased aldosterone, which leads to decreased Na reabsorption and hence decreased K excretion
- contraindicated in pregnancy - foetal problems
- contraindicated in renal stenosis - decreased efferent renal arteriole constriction, which decreases the pressure gradient across the Bowman’s capsule, which leads to decreased GFR
Describe diuretics.
They increase sodium and water excretion. This reduced blood volume, which reduces CO, which reduces BP.
There are different types, such as loop diuretics, thiazides and potassium-sparing diuretics.
Some of their major side-effects are:
- hypokalaemia (with loop and thiazide, but not K-sparing)
- lipid abnormalities
- glucose intolerance/ hyperglycaemia (decreased insulin release)
What are the consequences of sympathetic nerve stimulation of the CVS?
β1 - increase HR and contractility, which increases CO, which increases BP
α1 - vasoconstriction, which increases TRP, which increases BP
How would you decrease sympathetic activity?
CNS: α2 adrenoreceptor agonists (eg. Clonidine, used in hypertensive crisis)
Ganglion blockers: NIC blockers (eg. Trimethapan, used in hypertensive crisis)
Synaptci blockade (eg. Reserpine, an old antihypertensive)
List some adrenoceptor blockers.
α1 blockers: cause the relaxation of vascular smooth muscle, eg. prazosin (used in hypertensive crisis)
β1 blockers: cause a reduction in CO and renin release (eg. atenolol)
