Treatment of CVS diseases, RAAS System

Question 1

THERE’S CLASSES OF ANTIHYPERTENSIVES
Describe them

Answer 1

1. Indapamine
2. Diuretics
3. Angiotensin Inhibitors
4. Direct Vasodilators
5. Thiazide-like diuretics
6. Calcium Channel Blockers

Question 2

Describe the Agents, MOA, and A/E and C/I of ACE Inhibitors

Answer 2

Agents “-pril”
1. Enalapril
2. Captopril
3. Ramipril
Mech, of Action
Blocks conversion of Ang 1 to Ang 2
Reduces preload and afterload
Reduce Aldosterone
Block vasoconstriction.
A/E
1. Dry Cough
2. Angioedema
3. Metabolic Acidosis
4. Hyperkalaemia
Caution with Spironolactone
C/I
1. Pregnancy
2. Bilateral Renal Stenosis

Question 3

Describe the Agents, C/I, A/E and MOA of Angiotensin Receptor Blockers

Answer 3

Agents
Valsartan/Losartan
MOA
Block the effect of Angiotensin 2 on Angiotensin type1 receptors

A/E- Same as for ACE Inhibitors, except DRY COUGH

**ARBs are preferred over ACE-I

Question 4

What is the role of ARB/s and ACE-I in Heart Failure

Answer 4

1. Reduce Preload
2. Reduce Filling Pressure
3. Decrease Vasoconstriciton
4. Decrease Afterload
5. Reduce Mortality by 35 percent