Treatment Flashcards

1
Q

What are the 6 classes of asthma treatment and examples

A
  1. SABA - Salbutamol, terbutaline
  2. Corticosteroids - beclametasone, flucitason
  3. LABA- salmeterol
  4. Leukotriene receptor anatagonists - monteklast
  5. Xanthanes - phenothylline
  6. Anti IgE (-mab)
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2
Q

What colour inhaler is salbutamol(Ventolin)?

A

Blue

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3
Q

What colour inhaler is beclametasone?

A

Brown

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4
Q

What colour inhaler is the combined fluclitasone and salmeterol?

A

Purple

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5
Q

How should method dose inhalers be taken?

A

Exhale, slow breathe in for 4-6s and hold for up to 10s

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6
Q

How should dry powder inhalers be taken?

A

Exhale, rapid breath in and hold for 10 seconds

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7
Q

Why would spacers be used?

A

To increase efficacy of inhalation, particularly in kids

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8
Q

How do SABA work? (salbutamel, terbutaline) and how long do they take to work?

A

They are B2 receptor agonists and lead to the relaxation of small muscle.

Work over a few minutes and peak at 30 minutes

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9
Q

How do corticosteroids work (Beclametisone, flucitasone) and how often are they taken?

A

They dampen down the immune response and reduce the action of eosinophils, T-cells

Daily dose or in emergency

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10
Q

What are SABA side effects?

A

Tremor

Tachycardia

Hypokalaemia

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11
Q

What are corticosteroid side effects?

A

If inhaled -Oral thrush/dry mouth

If on a large dose - Cushing type syndome - Hyperglycaemia, weaken immune system, weight gain, thin skin and bruising, osteoporosis, mood changes

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12
Q

How do LABA (salmeterol, formeterol) work?

A

Same as SABA but over a long period of time. They last 12 hours

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13
Q

Can LABA and SABA be used together?

A

Yes

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14
Q

What should a LABA always be prescribed with?

A

Corticosteroid

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15
Q

What group are LABA contraindicated in?

A

Under 5s

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16
Q

What is an example of a corticosteroid and LABA together?

A

The purple one, flucitasone and salmeterol

17
Q

How do the leukotriene antagonists work (Monteklast)?

A

They work by inhibiting the inflammatory mediated leukotriene and are well tolerated

Inhibit phosphodiesterase

18
Q

How do the Xanthanes (theophylline) work?

A

Like beta agonists in blocking cAMP breakdown and therefore causing smooth muscle relaxation

19
Q

What are the side effects of theophophylline

A
  • It has a very narrow therapeutic window
  • Nausea and vomiting
  • Tachycardia
  • Convulsions
  • Coma
  • Upregulates p450

It’s half life is affected by many things, eg macrolides increase and rifampicin decrease

20
Q

How does omalizumab work?

A

Anti IgE so suppresses immune response

21
Q

When is magnesium sulphate given?

A

IV in emergency situations

22
Q

What treatment upregulates p450?

A

Theophyllines

23
Q

Which treatment can cause bronchospasm?

A

NSAIDS

24
Q

Which treatment can cause insomnia?

A

Prednisolone

25
Q

What treatment inhibits phosphodiesterase?

A

Leukotriene antagonists