Treatment Flashcards
What is the preferred method of axillary lymph node staging?
Sentinel lymph node biopsy
Sentinel nodes are the first lymph nodes to which cancer may spread from a primary tumor.
What surgical procedure is performed if sentinel nodes are positive?
Axillary lymph node dissection
This is done if palpable or biopsy-proven positive lymph nodes are present in the axilla.
What type of therapy is indicated for ER+ and/or PR+ patients?
Adjuvant endocrine therapy
This therapy is recommended by NCCN guidelines.
Which medication is used for premenopausal women in endocrine therapy?
Tamoxifen
It is given for 5 to 10 years, with or without ovarian suppression or ablation.
What are the aromatase inhibitors used in postmenopausal women?
Anastrozole, letrozole, exemestane
These are nonsteroidal aromatase inhibitors.
What is the potential benefit of adding aromatase inhibitors to treatment?
Increased treatment effectiveness
The benefit of adding aromatase inhibitors is still being studied.
What are some potential side effects of aromatase inhibitors?
Hot flashes, joint aches, loss of bone density, dry skin, vaginal dryness, decreased libido
These side effects may vary among individuals.
What type of disease is trastuzumab (Herceptin) used to treat?
HER2-positive disease
This monoclonal antibody is used in targeted therapy.
What are the potential side effects of trastuzumab?
Allergic reaction, decreased left ejection fraction, pulmonary toxicity, rash, fatigue
These side effects can significantly affect patients’ health.
What is the role of pertuzumab (Perjeta) in cancer treatment?
Monoclonal antibody therapy
It is used in combination with chemotherapy.
Fill in the blank: Chemotherapy for locally advanced and/or metastatic disease includes _______.
Antihormonal therapy, chemotherapy agents
These treatments are part of the management strategy.
What are some preferred chemotherapy regimens?
TAC, Dose-dense AC, AC followed by weekly paclitaxel, TC, EC, CMF
These regimens are based on various clinical trials.
What is the acronym for the combination of docetaxel, carboplatin, and trastuzumab?
TCH
This regimen is used for treating HER2-positive cancers.
True or False: Tamoxifen and aromatase inhibitors can be taken at the same time.
False
They should not be taken concurrently.
What is the role of CDK 4/6 inhibitors in metastatic disease?
Targeted therapy
They are used in combination with other treatments like aromatase inhibitors.
