treatment Flashcards
1
Q
Eltrombopag trial name and journal
A
RACE
NEJM 2022
2
Q
triple therapy regimen
A
horse ATG 40mg/kg for 4 days
CSA 5mg/kg/day on day 1
Eltrombopag 75mg daily starting day 14
3
Q
steroid tapering
A
MP 1mg/kg/day for at least 7 days then taper within 2-3 weeks
4
Q
CSA regimen
A
continued for at least 12 months then slow tapering in the next 6-12 months (~10% per month)
remain on treatment for at least 18 months
5
Q
CSA trough level
A
monoclonal assay - 150-250
polyclonal assay 200-400
6
Q
eltrombopag regimen
A
continue for 3 months if CR
continue for 6 months if PR at 3 months or no response at 3 months
7
Q
RACE primary end point
A
CR at 3 months
22% vs 10%
8
Q
RACE ORR at 3 months
A
59% vs 31%
9
Q
RACE ORR at 6 months
A
68% vs 41%
10
Q
RACE CR at 6 months
A
32% vs 20%
