TRAT Antidepressant Flashcards
Which SSRI has a warning about QTc prolongation and is dose limited to 40 mg/day?
Citalopram
Which SSRI has the most weight gain?
Paroxetine
What is a good thing and a bad thing about vilazodone?
good:
combined MOA: SSRI and 5HT1A receptor partial agonist
bad:
FDA warning for increased risk of bleeding -> DDI with Aspirin, NSAIDs, Anticoagulants, Antiplatelets
-DDI with CYP3A4 inhibitor (when given with CYP3A4i -> max dose 20 mg)
Which SNRI is notorious for increasing blood pressure?
venlafaxine
What 2 antidepressants have the worse discontinuation syndrome?
venlafaxine, and paroxetine
Which SSRI is indicated just for obsessive-compulsive disorder?
Luvox, which is Fluvoxamine
Which SSRI has anticholinergic properties and should not be used in the elderly?
Paroxetine
Which SSRI has a long half-life and self-tapers?
Fluoxetine
What are the 2 most common adverse effects of mirtazapine that can be used clinically in certain patients?
somnolence and weight gain
Contraindications to bupropion?
seizure disorders, eating disorders, recent MAOI use ( 2 weeks), severe liver disease
Which drug should be avoided in patients having depression and anxiety?
Bupropion (NET/DAT reuptake inhibitor)
-> activating effect -> more anxiety
-also other antidepressant can cause it
-reduce the dose of antidepressants
What is the most common side effect of SSRIs?
-GI: nausea, diarrhea (fluoxetine, sertraline, and citalopram are worst - Paroxetine cause constipation (anticholinergic) avoid in patients over 65
-headache
->transient, they go away
take it with food in the first week
What is a long-term side effect of SSRIs?
-sexual dysfunction
-weight gain
-increased bleeding (antiplatelet effects)
-sometimes Hyponatremia (check the Na levels)
Which antidepressants don’t cause sexual dysfunction?
-buproprion
-Mirtazepine
-Duloxetine (low)
-Vilazodone
