Transporters as drug targets Flashcards
Name the 3 major types of transmembrane Transporter proteins.
1) Passive transport - channels and transporter proteins facilitate movement DOWN conc gradient
2) Active - Energy is used from ATP to pump solutes UP the conc gradient
3) Coupled (Symporters and Antiporters) - use potential energy to move solutes up their gradient
Transporters in the kidney are known as Diuretics. TRUE or FALSE ?
TRUE
What is the role of diuretics and how do thy carry out this role?
Increase urine output;
by inhibiting the sodium pumps therefore inhibiting water being reabsorbed
Na+K+ATPase is the driving force behind the re absorption of Na+ (throughout the nephron). TRUE or FALSE ?
TRUE
Digoxin acts on Na+K+ATPase and does what ?
Increases the power of each cardiac muscle contraction therefore increases cardiac output
What happens during excitation of Cardiac tissue ?
Influx of Calcium and release of calcium from Intracellular stores
Calcium promotes myofibre contraction. TRUE or FALSE ?
TRUE
Digoxin inhibits Na+K+ Antiporter. TRUE or FALSE ?
TRUE
Heart failure is as a result of inadequate cardiac output. TRUE or FALSE ?
TRUE
Antidepressants act as transporters in the brain. TRUE or FALSE ?
TRUE
Name 4 examples of Antidepressants
1) SSRRI’s (serotonin specific reuptake inhibitors)
2) SNRI’s (serotonin and nor-ad reuptake inhibitors)
3) Nor-ad
4) Dopamine
What do Tri-cyclic antidepressants do ?
Inhibits 1) serotonin and nor-ad reuptake
2) Other off target effects.
Proton pump inhibitors regulate stomach acidity. TRUE or FALSE ?
TRUE
How do proton pump inhibitors work ? Give an example of a drug that acts as a proton pump inhibitor.
1) bind irreversibly to proton pumps
2) Inhibit proton excretion to the stomach
3) facilitates healing of gastric ulcers
-Omeprazole
Proton pump acts on H+K+ATPase. TRUE or FALSE ?
TRUE
