Transporters as drug targets

Question 1

Transporter families

Answer 1

1) Ion transporters + pumps
2) Metabolite transporters
3) Neurotransmitter transporters

Question 2

Pumps

Answer 2

- Can be divided into 4 categories, 3 being for ion transport
\+ P-class
\+ V-class
\+ F-class
\+ ABC superfamily pumps

Question 3

Metabolite transporters

Answer 3

• Currently 31 families
• Very important drug targets
• ie Chloroquine Resistance Transporter (CRT)
• Also known as DMT

Question 4

Neurotransmitter transporters

Answer 4

• 2 classes: Vesicular + Plasma Membrane

- Mainly exploited for neuronal identification + research

Question 5

Vesicular class Neurotransmitter Transporters

Answer 5

• Includes:
  + Vesicular inhibitory aa transporters
  + Vesicular excitatory aa transporters
  + Vesicular amine transporters

Question 6

Plasma membrane class Neurotransmitter Transporters

Answer 6

- Includes
\+ Noradrenaline transporter (NET)
\+ Dopamine transporter (DAT)
\+ 5-HT transporters
\+ Excitatory aa transporters
\+ GAT-GABA transporters
\+ GlyT-glycine transporters

Question 7

Glutamate transporters

Answer 7

• A type of neurotransmitter transporter that hasn’t been mentioned in my notes for some reason
• Diagram-wise represented by EAATs