Transporters Flashcards

1
Q

Function, Nephron segment, which membrane?

Na-K ATPase

A

Function: drives everything; keeps Na concentration low inside the cell

Nephron segment: all

Membrane: basolateral

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2
Q

Function, Nephron segment, which membrane?

H-K ATPase

A

In basolateral membrane of B-IC cells of late DT and CCD: reabsorbs H and secretes K. K will leak out apical membrane via K-channels

In apical membrane of A-IC cells of late DT and CCD: reabsorbs K and secretes H. K will leak out basolateral membrane via K-channels

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3
Q

Function, Nephron segment, which membrane?

H-ATPase

A

In basolateral membrane of beta-IC cells of late DT and CCD: Reabsorbs H made by H2CO3. The resultant HCO3- is secreted into tubule via Cl-HCO3 antiporter on apical membrane.

In apical membrane of alpha-IC cells of late DT and CCD: Secretes H made by H2CO3. The resultant HCO3 is reabsorbed into blood via Cl-HCO3 antiporter on basolateral membrane.

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4
Q

Function, Nephron segment, which membrane?

Ca-ATPase

A

Function: reabsorbs Ca into blood

Nephron segment: PT

Membrane: basolateral

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5
Q

Function, Nephron segment, which membrane?

ENaC

A

Function: epithelial sodium channels. Aldosterone sensitive

Nephron segment: late DT and CCD

Membrane: apical

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6
Q

Function, Nephron segment, which membrane?

Aquaporins

A

Function: water channels, goverened by starling forces and upregulated by ADH

Nephron segment: PT, thin descending LOH, late DT/CCD

Membrane: varies on subtype (type 2 on apical)

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7
Q

Function, Nephron segment, which membrane?

TRPV5

A

Function: Active reabsorption of Ca++

Nephron segment: DT

Membrane: apical

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8
Q

Function, Nephron segment, which membrane?

TRPM6

A

Function: Mg+ selective channel, depends on NaCl reabsorption via NCC and Na/K-ATPase. But most Mg reabsorption is paracellular

Nephron segment: Early DT

Membrane: Apical

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9
Q

Function, Nephron segment, which membrane?

SGLT

A

Function: Symporter that croses Na and glucose into the cell for reabsorption

Nephron segment: Early PT

Membrane: Apical

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10
Q

Function, Nephron segment, which membrane?

GLUT

A

Function: Transports glucose out of cell into blood

Nephron segment: Early PT

Membrane: Basolateral

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11
Q

Function, Nephron segment, which membrane?

Na-H Antiporters

A

Function: Trades Na for reabsorption and secretes an H

Nephron segment: Early and late PT

Membrane: apical

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12
Q

Function, Nephron segment, which membrane?

Na-K-2Cl co-transporter

A

Function: Primary mode of reabsorption in TAL

Nephron segment: TAL

Membrane: Apical

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13
Q

Function, Nephron segment, which membrane?

NaCl cotransporter

A

Function: primary mode of Na reabsorption in late PT; coupled to function of Na-H and Cl-base antiporters. NCC - primary mode of Na reabsorption in early DT

Nephron segment: Early and late PT

Membrane: Apical

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14
Q

Function, Nephron segment, which membrane?

Na-HCO3 co-transporter

A

Function: Biggest Na-buddy at this region. Reabsorbs both Na and HCO3

Nephron segment: Early PT

Membrane: apical

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15
Q

Function, Nephron segment, which membrane?

Cl-HCO3 antiporter

A

In apical membrane of beta-IC cells of late DT and CCD; secretes HCO3 made by H2CO3

In basolateral membrane of alpha-IC cells of late DT and CCD; reabsorbs HCO3 made by H2CO3

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16
Q

Function, Nephron segment, which membrane?

Na-Pi symporter

A

Function: Reabsorbs Na with a Pi

Nephron segment: Early PT

Membrane: apical

17
Q

Function, Nephron segment, which membrane?

Na-amino acid symporter

A

Function: reabsorbs an Na with an amino acid

Nephron segment: Early PT

Membrane: apical

18
Q

Function, Nephron segment, which membrane?

OAT 1-3

A

Function: Secretes organic anion into the cell in exchange for alpha-KG

Nephron segment: PT

Membrane: basolateral

19
Q

Function, Nephron segment, which membrane?

OCTs

A

Function: Secretes cations into the cell

Nephron segment: PT

Membrane: basolateral