Transport of hydrogen ions between tissues and lungs

Question 1

binding of H+ ions

Answer 1

H+ ions generated by co2 reactions binds to deoxyhemoglobin (has greater affinity for it than oxyhemoglobin)
HbO2 + H+ HbH + O2
small manner of H+ generated remains free

Question 2

pHs of blood

Answer 2

systemic venous blood - 7.36

systemic arterial blood - 7.40

Question 3

what happens as venous blood passes through the lungs?

Answer 3

reaction reversed
deoxyhemoglobin is converted to oxyhemoglobin and H+ is released
H+ reacts with HCO3-
normally, all of it recombines to form co2 and water - none appears in arterial blood

Question 4

hypoventilation/lung disease preventing elimination of co2

Answer 4

increased arterial Pco2 and arterial H+ conc

Question 5

respiratory acidosis

Answer 5

increased arterial H+ conc due to co2 retention

Question 6

respiratory alkalosis

Answer 6

decreased arterial H+ conc due to reduced co2 by hyperventilation

Question 7

factors decreasing affinity of hemoglobin for oxygen

Answer 7

increased H+ conc, Pco2, temp and DPG conc

Question 8

hemoglobin and nitric oxide

Answer 8

theoretically, it can bind and transport it - carries it to peripheral tissues, releases it alongside oxygen
via diff. binding site, it can pick it up when its production is increased and catabolise it
determining peripheral conc. and its vasodilatory effects