Transplant meds Flashcards by reid sakamoto | Brainscape

Q

Cyclosporine MoA

A

inhibits calcineurin and IL-2 synthesis

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Q

Cyclosporine Adverse Effects

A

nephrotoxic
tremor
HTN
hirsutism

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Q

Tacrolimus MoA

A

binds to FKBP

inhibits calcineurin and IL2 synthesis

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Q

Tacrolimus Adverse Effects

A

nephrotoxic
HTN
Neurotoxic
GI toxicitiy (nausea and diarrhea)

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Q

Mycophenolate MoA

A

antimetabolite

inhibits de novo purine synthesis

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Q

mycophenolate Adverse Effects

A

GI toxicity

leukopenia

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Q

Sirolimus MoA

A

inhibits lymphocyte effects driven by IL2

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Q

Sirolimus Adverse effects

A

thrombocytopenia

increase cholesterol/LDL

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Q

corticosteroids MoA

A

inhibits lymphokine production

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Q

coritosteroids Adverse Effects

A

cushingoid state
glucose resistance
osteoporosis

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Q

Azathioprine MoA

A

antimetabolite

interferes with DNA and RNA synthesis

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Q

Azathioprine Side Effects

A

Thrombocytopenia
neutropenia
liver dysfunction

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