Translocations in Hematological Malignancies Flashcards
1
Q
t(14;18)(q32;q21)
A
BCL2. B-cell leukemia, follicular lymphoma. Southern blotting, PCR.
1
Q
(9;22)(q34;q11)
A
Philadelphia chromosome. Chronic myelogenic leukemia, adult acute lymphoblastic leukemia. BCR-abl. Southern blotting, rtPCR, qPCR better.
1
Q
<p class=”large” style=”text-align:center”;>t(15;17)(q22;q11.2-q12)</p>
A
<p class=”large” style=”text-align:center”;>PML/RARA. Found in promyelocytic leukemia. Also indicative of retinoids acid treatment. PCR or RTPCR.</p>
1
Q
t(11;14)(q13;q32)
A
BCL1. Associated with mantle cell lymphoma. PCR.
1
Q
t(8;14)(q24;q11)
A
c-myc. Burkitt’s lymphoma. Southern blot, Northern blot, FISH.