Translocations

Question 1

CML

Answer 1

(9;22) Philadelphia chromosome

Question 2

PV

Answer 2

JAK2V617F

Question 3

PM

Answer 3

~50% JAK2V617F

25-35% calreticulin

Question 4

Mastocytosis

Answer 4

c-KIT

Question 5

AML Good prognosis

Answer 5

t(15;17): acute promyelocytic leukemia
t(8;21)
inv16 or t(16;16): acute myelomonocytic leukemia w/ abnormal eosinophils

Question 6

AML Poor prognosis

Answer 6

5q-, 7q-

Question 7

MDS

Answer 7

-5, 5q-
-7, 7q-
+8
20q-

Question 8

Langerhans Cell Histiocytosis

Answer 8

BRAF

Question 9

ALL

Answer 9

Hyperdiploidy (51-65)
t(4;11): poor
t(9;22); intermediate P190
t(12;21)

Question 10

CLL/SLL

Answer 10

unmutated
mutation

Good: deletion 13q
bad: deletion 11q, deletion 17q, trisomy12

Question 11

Hairy Cell Leukemia

Answer 11

BRAF

Question 12

Follicular Lymphoma

Answer 12

t(14;18)–>overexpression of BCL-2

Question 13

Diffuse Large B-cell Lymphoma

Answer 13

KSHV/HHV8

EBV

Question 14

Burkitt’s Lymphoma

Answer 14

EBV

t(8;14)

Question 15

Mantle Cell Lymphoma

Answer 15

t(11;14) (q34;q32)

Question 16

Adult T-cell leukemia

Answer 16

HTLV-1

Question 17

Anaplastic Large Cell Lymphoma

Answer 17

t(2;5)

Question 18

Peripheral T-cell lymphoma

Answer 18

TCR gene rearrangement