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path block 6 > translocations > Flashcards

translocations Flashcards

1
Q

t(12;21)

A

B-ALL

good prognosis

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2
Q

t(9;22)

A

philadelphia chromosome (BCF-abl = constit active tyrosine kinase), seen in CML and B-ALL

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3
Q

t(15;17)

A

acute promyelocytic leukemia

impairs function of RAR

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4
Q

t(14;18)

A

follicular lymphoma

Ig heavy chain-BCL2 impairs apoptosis

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5
Q

t(11;14)

A

mantle cell lymphoma

Ig head chain-cyclin D increases progression from G1-S

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6
Q

t(8;14)

A

burkitt lymphoma

Ig heavy chain- cmyc

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7
Q

t(8;21)

A

acute megakaryoblastic leukemia

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8
Q

JAK2 kinase

A

polycythemia vera, essential thrombocytosis, myelofibrosis

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9
Q

BCL6

A

DLBCL

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