Translesion Polymerases Flashcards
1
Q
What do eukaryotic Y-family polymerases bind (2)
A
Rev1, ubiquitin, and PCNA
2
Q
What are the two major players in the SOS response?
A
Pol V and RecA-ATP
3
Q
What three mechanisms keep Pol V in check
A
Synthesis of Pol V only occurs during SOS response
Requires activation by RecA
Pol III has a greater affinity for beta-clamp than Pol V
4
Q
What upregulates polymerase switching in eukaryotes?
A
Ubiquitination of PCNA
