Transfusion

Question 1

preformed antibodies that lyse donor erythrocytes

Answer 1

Acute hemolytic transfusion reactions

Question 2

sensitization to RBC alloantigens

Answer 2

Delayed hemolytic and serologic transfusion reactions

Question 3

antiHLA antibodies, cytokines released from leukocytes in non-leukoreduced blood

Answer 3

Febrile nonhemolytic transfusion reaction

Question 4

plasma proteins

Answer 4

Allergic reactions

Question 5

donor T lymphocytes that attack host HLA antigens

Answer 5

GVHD

Question 6

the transfused, alloantibody coated erythrocytes are cleared by the reticuloendothelial system which causes recurrence of anemia

Answer 6

Delayed hemolytic and serologic transfusion reactions

Question 7

characterized by chills and rigors and a ≥1°C rise in temperature

Answer 7

Febrile nonhemolytic transfusion reaction

Question 8

severe allergic reaction presents after transfusion of only a few milliliters of the blood component with difficulty breathing, coughing, nausea and vomiting, hypotension, bronchospasm, loss of consciousness, respiratory arrest, and shock

Answer 8

Anaphylactic reaction

Question 9

development of fever, cutaneous eruption, diarrhea and liver abnormalities in 8-10 days with death 3-4 weeks posttransfusion

Answer 9

GVHD

Question 10

donor plasma that contains high-titer antiHLA class II antibodies that bind recipient leukocytes

Answer 10

TRALI

Question 11

Recipient develops symptoms of hypoxia (PaO2/FiO2 < 300 mmHg) and signs of non-cardiogenic pulmonary edema, including bilateral interstitial infiltrates on chest x-ray, either during or within 6 hrs of transfusion

Answer 11

TRALI

Question 12

antibodies that react to both donor and recipient platelets

Answer 12

Posttransfusion purpura

Question 13

presents as thrombocytopenia 7-10 days post platelet transfusion

Answer 13

Posttransfusion purpura

Question 14

refractoriness to platelet transfusions

Answer 14

Alloimmunization