Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Dispensing F13 Exam III > Transdermal Drug Delivery Systems > Flashcards

Transdermal Drug Delivery Systems Flashcards

0
Q

2 types of transdermals

A
  • adhesive matrix

- reservoir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

2 advantages of transdermals

A
  • avoid 1st pass effect by the liver

- increase pt. compliance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

adhesive matrix

A
  • drug is evenly distributed, so can be cut in half

- contains a release liner and drug is released from adhesive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

reservoir

A
  • cannot be cut because drug would leak
  • contains a rate-controlling membrane and a reservoir filled with drug formulation
  • adhesive on both sides, not in the middle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

flux

A

rate of diffusion through the skin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Minitran, Nitro-Dur

A

nitroglycerin transdermal system

  • category: vasodilator
  • ind. for prevention of angina pectoris
  • adhesive matrices
  • Minitran: 0.1mg/hr
  • main side effect: headache (usually diminishes over time)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how to minimize nitroglycerin tolerance?

A

wear for 12 hours and remove for 12 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Ranexa

A

ranolazine

  • category: vasodilator
  • ind. for prevention of angina
  • BID
  • tab: 500mg, 1000mg
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

estradiol

A

an estrogen hormone ind. for hormone replacement therapy (HRT) in post-menopausal women
BBW: increase risk of CVD and dementia in post-menopausal women, increase risk of endometrial cancer in pre-menopausal women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Climara

A

estradiol adhesive matrix system

  • ind. for VM, VA, and O
  • qweek
  • strengths: 0.025mg/24hr, 0.0375, 0.05, 0.06, 0.075, 0.1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

atrophic vaginitis

A

inflammation of the vagina due to thinning and shrinking of tissues, caused by decreased estrogen levels
-estradiol restores normal vaginal mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

symptoms of vaginal atrophy

A

soreness, pain during intercourse, bleeding during intercourse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

dyspareunia

A

painful intercourse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Vivelle-Dot

A

estradiol adhesive matrix system

  • ind. for VMS, VA, O
  • BIW
  • strengths: 0.025mg/24hr, 0.0375, 0.05, 0.075, 0.1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Alora

A

estradiol adhesive matrix system

  • ind. for VMS, VA, O
  • strengths: 0.025mg/24hr, 0.05, 0.075, 0.1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Menostar

A

estradiol adhesive matrix system

  • ind. ONLY for O
  • low dose estrogen
  • qweek
  • one strength: 0.014mg/24hr
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Estrasorb

A

estradiol topical emulsion (0.05mg/2 packets)

  • ind. for VMS, VA, O
  • individually wrapped packets of estradiol
  • qAM
  • -one packet on left leg and right leg for 3 minutes
  • -rub excess on buttocks
  • contains soybean oil and alcohol USP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Evamist

A

estradiol transdermal spray 0.021mg/spray

  • ind. for VMS, VA, O
  • qday
  • spray on inside of forearm
  • contains alcohol USP and octisalate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Divigel

A

estradiol topical gel 0.1% (30 packets/box)

  • ind. for VMS, VA, O
  • qday - apply one packet to upper thigh
  • individually wrapped packets of gel:
  • -0.25g(0.25mg of estradiol), 0.5g(0.50mg), 1g(1mg)
  • contains alcohol USP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Femring

A

estradiol vaginal ring

  • ind. for VMS, VA, O
  • strengths: 0.05mg/24hr, 0.1mg
  • can be felt during sex, can come out during sex or when straining with a bowel movement
  • -if it comes out, wash off and reinsert
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Vagifem

A

estradiol vaginal tablet (10mcg)

  • ind. for VA
  • tablet inserted with applicator
  • initial: 1 qday x 2 weeks, then 1 tab BIW
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Premarin Vaginal Cream

A

conjugated/equine estrogens vaginal cream

  • ind. for VA
  • BIW
  • 0.625mg/g cream
  • applicator calibrated in 0.5g increments up to 2g
  • derived from the urine of pregnant horses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Climara Pro

A

estradiol, levonorgestrel adhesive matrix system

  • ind. for VMS, O
  • qweek
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

progestin

A

synthetic progesterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

CombiPatch

A

estradiol, norethindrone adhesive matrix system

  • ind. for VMS, VA
  • BIW
  • refrigerate in the pharmacy, pt. can store at RT
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

levonorgestrel, norethindrone, norelgestromin

A

progestins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Activella

A

estradiol, norethindrone

  • ind. for VMS, VA, O
  • qday
  • oral tablet: 0.5mg estradiol/0.1mg norethindrone, 1mg/0.5mg
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Ortho Evra

A

ethinyl estradiol, norelgestromin adhesive matrix system

  • ind. for contraception
  • apply 1 patch every week for 3 weeks, 1 week off, then repeat
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Androderm

A

testosterone reservoir patch system

  • ind. for male hypogonadism
  • strengths: 2mg/24hr, 4mg/24hr
  • contains alcohol USP
  • don’t use the same site more than once per week because it causes irritation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

anabolic steroids

A
  • synthetic derivatives of testosterone

- may cause hepatotoxicity and paranoid jealousy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

men’s normal daily production of testosterone

A

5mg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Anabolic Steroids Control Act

A

made all anabolic steroids schedule 3 drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

hypogonadism

A

decreased activity of the gonads so insufficient secretion of testosterone
-decreased libido and energy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

libido

A

sex drive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

AndroGel

A

testosterone topical gel

  • qday
  • absorb 10% of dose
  • single dose packets: 2.5g(25mg), 5g(50mg)
  • -rub contents of 1 packet on shoulder
  • metered-dose pump: 1%(1 pump contains 12.5mg) X4= 50mg, 1.62%(1 pump contains 20mg) X2=40mg
  • apply to shoulders or arms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Testim

A

testosterone single dose packets

  • qday
  • 5g(50mg)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Fortesta

A

testosterone metered-dose pump

  • qday
  • 1 pump contains 10mg X4 pumps= 40mg
  • 2 pumps are applied to each thigh which minimizes secondary exposure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Axiron

A

testosterone

  • qday
  • topical solution
  • metered-dose pump: 1 pump contains 30mg X 2(1 under each arm) = 60mg
  • -spray 1 pump in cup and apply under each arm like roll-on deodorant
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

BBW for testosterone

A

secondary exposure in women and children can cause virilization
-wash hands after use and avoid women and children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

virilization

A

development of masculine characteristics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

testosterone drug interactions

A

decreases anticoagulant and insulin requirements

41
Q

Catapress-TTS

A

clonidine reservoir system

  • ind. for HTN
  • 0.1mg/24hr, 0.2mg, 0.3mg
  • contain optional adhesive overlay covers to keep patch on
  • DON’T stop cold turkey, switch to tablets and then taper*
42
Q

Kapvay

A

clonidine ER tablet

  • ind. for ADHD
  • strengths: 0.1mg, 0.2mg
  • maintenance dose BID
43
Q

Duragesic

A

fentanyl reservoir system (CII)

  • ind. for chronic pain
  • opioid-naive pts: 12.5mcg/hr, 25mcg/hr
  • opioid-tolerant pts: 50, 75, and 100 mcg/hr
  • commonly abused
  • contains alcohol USP
44
Q

Actiq

A

fentanyl lozenge on a stick

  • opioid analgesic
  • rub on inside of cheek for about 15 mins
  • onset in approx. 15 mins
45
Q

Onsolis

A

fentanyl buccal film

  • opioid analgesic
  • apply to inside of cheek
46
Q

Fentora

A

fentanyl buccal tablet

-opioid analgesic

47
Q

Abstral

A

fentanyl sublingual tablet

-opioid analgesic

48
Q

Lazanda

A

fentanyl nasal spray

  • opioid analgesic
  • 1 spray in 1 nostril
49
Q

Transderm-scop

A

scopolamine adhesive matrix system

  • anticholinergic agent
  • ind. for prevention of N/V assoc. with motion sickness and in pts. recovering from anesthesia after surgery
  • motion sickness: place behind ear 4hr before needed, may leave on up to 3 days then put new patch behind other ear if needed
  • surgery: apply 1 patch the evening before surgery
  • pt. counseling: wash hands thoroughly after applying or removing b/c it may cause mydriasis and most common adverse effects are dry mouth and drowsiness
50
Q

Zyban

A

bupropion

  • aminoketone antidepressant
  • ind. ONLY for smoking cessation
  • start 1 week before trying to quit to give drug a chance to reach therapeutic levels
  • tablet: 150mg, take 1 qday X 3D, then BID X 12 weeks
51
Q

Wellbutrin

A

bupropion

  • aminoketone antidepressant
  • ind. ONLY for depression but will work for smoking cessation
52
Q

Chantix

A

varenicline

  • nicotine receptor agonist
  • tablet: 0.5mg, 1mg
  • side effects: N/V(take with food), vivid bad/weird dreams, violent behavior(#1 drug that causes this)
  • BBW: do not use in pts. with depression, bipolar disorder, or schizophrenia*
53
Q

Minivelle

A

estradiol transdermal system

  • ind. for VMS, VA, O
  • BIW
54
Q

Nicorette Gum

A

nicotine (OTC)

  • ind. as an aid to smoking cessation for the relief of nicotine withdrawal symptoms
  • contains a sugar free base that provides systemic delivery of nicotine - will not work if swallowed
55
Q

Nicorette

A 
nicotine 2mg (OTC)
-pts. who smoke 25 or less cigarettes per day start with this strength
56
Q

Nicorette DS

A 
nicotine 4mg (OTC)
-pts. who smoke >25 cigarettes per day should start with this strength
57
Q

Nicorette pt. counseling

A
  • absorbed through the buccal mucosa, avoid swallowing as much as possible
  • rate and extent of nicotine absorption is pH dependent (needs alkaline saliva), so avoid coffee, soft drinks, fruit juices, etc. that make saliva acidic
  • do not chew continuously - when tempted to smoke, chew 1 piece until the peppery taste or tingling is perceived then place between cheek and gum until taste is gone, repeat in about 30 mins.
58
Q

nicotine lozenge

A
  • OTC
  • 2mg, 4mg dep. on time to first cigarette
  • -after 30 min. of waking is 2mg
  • -within 30 min. of waking is 4mg
  • take 1 lozenge q1-2h X6weeks, then q2-4h X3weeks, then q4-8h X3 weeks
  • depends on alkaline saliva
59
Q

Nicotrol inhaler

A

nicotine (Rx only)

  • each cartridge is 4mg: max dose/day = 16 cartridges
  • -contains enough nicotine for 20 mins. of active puffing
  • transmucosal - should not be inhaled into the lungs
60
Q

Nicoderm CQ

A

nicotine adhesive matrix system (OTC)

  • ind. as an aid to smoking cessation
  • strengths: 7mg/24hr, 14mg, 21mg
  • apply qday to a clean, hairless dry area on upper outer part of the arm
  • -remove after 24hr and apply a new system to a diff. site (do not reuse site for 7 days
  • -fold system in half to discard and wash hands after handling
61
Q

should you smoke while using nicotine products?

A

no

62
Q

can you sell nicotine products OTC to people under 18?

A

no

63
Q

Nicoderm CQ dosing

A 
>10cigs/day:
--21mg X 6 weeks
--14mg X 2 weeks
--7mg X2 weeks
< or equal to 10cigs/day:
--14mg X 6 weeks
--7mg X 2 weeks
64
Q

Lidoderm

A

lidocaine 5% adhesive matrix system

  • local anesthetic
  • qday
  • ind. for pain assoc. with PHN (Herpes zoster and Varicella virus)
  • apply up to 3 patches/day at the same time; put on for 12hr then take off for 12hr
  • does not contain a PAE
65
Q

Neurontin

A

gabapentin

-ind. for PHN and partial

66
Q

Lyrica

A

pregabalin

-ind. for PHN, partial, DPN, and fibromyalgia

67
Q

Varivax

A

varicella vaccine

  • chicken pox vaccine for children or adults
  • should not get chicken pox or shingles
68
Q

Zostavax

A

zoster vaccine

  • only ind. for pts. over 50
  • prevents reactivation of varicella virus
69
Q

Oxytrol

A

oxybutynin 3.9mg/24hr adhesive matrix system

  • anticholinergic = antispasmodic
  • BIW
70
Q

3 main symptoms of OAB

A

urinary incontinence, urgency, and frequency

71
Q

micturition

A

urination

72
Q

Ditropan XL

A

oxybutynin ER tablet

-anticholinergic

73
Q

oxybutynin

A

IR tablet

74
Q

Gelnique

A

oxybutynin 10% topical gel

  • anticholinergic
  • qday
  • individually wrapped packets of gel
  • apply to abdomen
  • contains a PAE
75
Q

Detrol

A

tolterodine IR tablet

  • anticholinergic
  • ind. for OAB
76
Q

Detrol LA

A

tolterodine ER capsule

  • anticholinergic
  • ind. for OAB
77
Q

Sanctura

A

trospium IR tablet

  • anticholinergic
  • ind. for OAB
  • take on ES*
78
Q

Sanctura XR

A

trospium ER capsule

  • anticholinergic
  • ind. for OAB
  • take on ES*
79
Q

Enablex

A

darifenacin

  • anticholinergic
  • ind. for OAB
80
Q

Vesicare

A

solifenacin

  • anticholinergic
  • ind. for OAB
81
Q

Toviaz

A

fesoterodine

  • anticholinergic
  • ind. for OAB
82
Q

side effects of anticholinergics (5)

A

xerostomia, constipation, sedation, mydriasis, hyperthermia (decreased sweating)

83
Q

Daytrana

A

methylphenidate adhesive matrix system (CII)

  • ONLY ind. for ADHD (used in children)
  • wear on hip 2hr before needed, then take off 9hr later so child will not have trouble sleeping
  • strengths: 10mg/9hr, 15mg, 20mg, 30mg
84
Q

Emsam

A

selegiline adhesive matrix

  • MAOI antidepressant
  • only patch ind. for depression
  • strengths: 6mg/24hr, 9mg, 12mg
  • more centrally active than other MAOIs, so less risk of hypertensive crisis
85
Q

selegiline pt. counseling

A
  • if taking 9 or 12mg, need to be careful with tyramine

- avoid pseudoephedrine and phenylephrine decongestants

86
Q

Eldepryl

A

selegiline ODT

  • antiparkinson’s agent
  • ONLY ind. for Parkinson’s Disease
87
Q

Zelapar

A

selegiline ODT

  • antiparkinson’s agent
  • ONLY ind. for Parkinson’s Disease
88
Q

Sancuso

A

granisetron adhesive matrix 3.1mg/24hr

  • antiemetic
  • qweek
  • ind. for N/V in pts. receiving chemo for 5 straight days (CINV)
  • apply on upper arm 24hr before first Tx, take off 24hr after last Tx
  • pt. counseling: may cause phototoxic reaction, avoid sun exposure to area patch was applied for 10 days following removal
89
Q

Aloxi

A

palonosetron

  • antiemetic
  • ind. for CINV
90
Q

Anzemet

A

dolasetron

  • antiemetic
  • ind. for CINV
91
Q

Zofran

A

ondansetron

  • antiemetic
  • ind. for CINV
92
Q

Emend

A

aprepitant

  • antiemetic
  • ind. for CINV
93
Q

Exelon Patch

A

rivastigmine adhesive matrix system

  • cholinesterase inhibitor
  • ind. for Alzheimer’s Disease
  • start on 4.6mg/24hr for one month, then increase to 9.5mg/24hr
  • apply patch to middle of the back so pt. will not remove
  • main SE: N/V
94
Q

Aricept

A

donepezil

-cholinesterase inhibitor

95
Q

Razadyne

A

galantamine

-cholinesterase inhibitor

96
Q

Butrans

A

buprenorphine adhesive matrix

  • opioid analgesic
  • strengths: 5mcg/24hr, 10mcg, 20mcg
  • -only use 10, 20mcg in opioid tolerant pts.
  • once patch is removed, do not use the same skin site for 3 weeks
  • also comes in sublingual tablet: ind. for addiction
  • parenteral - Buprenex
97
Q

Flector

A

diclofenac epolamine 1.3% adhesive matrix

  • NSAID
  • ind. for pain due to strains, sprains, and bruises
  • BID
  • if allergic to aspirin, do not use Flector
98
Q

strain

A

muscle stretched too far

99
Q

sprain

A

ligament stretched too far

100
Q

Estrace

A

estradiol 0.1mg/g cream

  • ind. for VA
  • applicator calibrated in 1g increments up to 4g
101
Q

Myrbetriq

A

mirabegron

-Beta-3 agonist

Dispensing F13 Exam III (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions