Transcription Factors/ Cell signaling Flashcards
Location of primordial germ cells during the 2nd week of development:
In the wall of the yolk sac.
Phase in which the secondary oocyte arrested until fertilization.
Metaphase II
Functions of Basic helix-loop-helix (bHLH) (5)
Muscle and nerve specification; drosophila sex determination; pigmentation.
Mesenchymal cell matrix secretion and degradation produces or removes:
ECM as for example in Cartilage mesenchyme.
Mesenchymal cell condensation:
Becomes epithelium for example in Cartilage mesenchyme.
Mesenchymal cell division:
Produces more cells by mitosis (hyperplasia) for example in limb mesenchyme.
Mesenchymal cell migration produces:
Heart mesenchyme by cell movement at a particular time and place.
PGCs migrate to the developing gonads (genital ridge) during the ___ week of development.
4th week.
Protein-protein interaction domain
Modulation of TF or dimerization
Fat cells are produced by:
Mesenchymal cell growth (hypertrophy)
Functions of Homeodomain function (7)
Axis formation, pituitary development, neural fate, head development, neural specification, eye development
Nobel price in 1935 for his work in primary induction.
Hans Spemann
The four steps of cell migration are:
- Cell polarization directed by:
- ECM signals and difussing signals - Protrusion of leading edge: polimerization of actin at the cell membrane Filopodia and Lamellipodia formation.
- Adhesion on ECM: integrins span cel, membrane in focal adhesions
- Release of adhesion in the rear (most-likely. Ediated by Stretch-sensitive calcium channels)
Where do PGC’s come from originally
From the primary ectoderm derived from the epiblast
Cadherins assist in properly positioning cells, which in turns allow for: (2)
- Separation of different tissue layers
2. Cellular migration.
The two mayor embryonic cells are:
Epithelial cells (sheets and tubes) and “loose” Mesenchymal cells.