Tranexamic Acid (TXA) Protocol

Question 1

TXA Universal Patient Guideline

Answer 1

▪ Primary Survey / Control Severe Traumatic Bleeding
▪ Shock Index = HR/SBP

Question 2

TXA Pharmacology

Answer 2

Tranexamic Acid is an antifibrinolytic medicine that stabilizes fibrinogen and
decreases plasmin formation.

Question 3

TXA Indications

Answer 3

• Traumatic Hemorrhagic Shock: Whole blood criteria
• Traumatic Brain Injury with GCS less than 13

Question 4

TXA Contraindications

Answer 4

▪ Injuries greater than 3 hours
▪ Age less than 5
▪ Non-Traumatic bleeding

Question 5

TXA Adult dosage

Answer 5

TXA: 2 Grams/100ml
▪ Infusion to be completed in a 10 drop set, 3 drops per second to provide 100 ml
over approximately 5 minutes.
▪ TXA can be given concurrently with Whole Blood

Question 6

TXA Pediatric Dosage (No Evidence of Puberty)

Answer 6

▪ 5-11 years of age use weight-based dosing
15/mg/kg as per the Medication Tool amount added to 100 ml NS and run in a 10 drop
set at 3 drops per second over approximately 5 min (Max dose = adult dose)