Trachte pharmacology Flashcards
mydriasis
pupillary dilator muscle contraction a1 receptor (Norepi)
sympathetic activates what muscle to hold eyelid open and through what receptors
superior tarsal muscle
a1 (norepi)
What muscles relax for distant vision and through what receptors
Ciliary muscle
Sympathetic –> b2 receptors (more by epinephrine - systemic, not very practical, PS more common for ciliary muscles)
aqueous humor formation through what receptor
sympathetic to B(2) receptors - block in glaucoma
inhibition of aqueous humor formation through what
sympathetic to a2 receptors
what focuses eye for near vision
parasympathetic –> muscarinic receptors –> ciliary muscle contraction
what constricts pupil (miosis)
PS –> muscarinic –> popillary sphincter contraction
what enhances drainage of aqueous humor
ps –> muscarinic –> trabecular meshwork & canal of schlemm
drugs promoting mydriasis
sympathomimetics (stimulate or mimic stimulation of symp nerves)
inhibitors of PS nervous system (atropine)
how does cocaine work
inhibit reuptake of norepi into cell
sympathetics overall
mydriasis (a1)
contract superior tarsal muscle (a1)
relax ciliary muscle (b2)
enhance AND inhibit aqueous humor formation
parasympathetics overall
focus eye for near vision - ciliary muscle
constrict pupil (miosis)
enhance drainage of aqueous humor
muscarinic receptors
phenylephrine
drug used in eye drops to dilate pupil
a1 adrenergic stimulant
epinephrine
a1 adrenergic stimulant
increases aqueous humor outflow and inhibits formation
cocaine will dilate eye if ___
sympathetics are release Norepi (issue with eye, not nerve)
If no response – horners