Toxicology Flashcards
Trichothecene
- Mycotoxin
- Decrease imunity + vomit
- A refuse to eat
Fesceu grass
Lameness + hyperthermia
Zeara-lenone
Estrogenism–vulvovaginitis
__________ prevent overeating of feed containing zeara-lenone
Deoxy-niva-lenol
Fumonisin
Fusarium sp. on moldy corn
Horse— CNS
Pig– high BP + lung edema
In horse ka EQUINE LEUKO-ENCEPHALOMALACIA
In piga ka PORCINE PULMONARY ODEMA
Ergotism
Parasitic fungus i.e. Claviceps purpurea
Ryegrass
Vasocontriction of extremitis—necrosis & gangrene
Pituitary effect—- agalactia
Inophore toxicity in horse
Colic + TC
Tying up—high creatinine kinase+posterior paralysis
Rx of inophore tox.
No antidote
Inophore tox. In CATTLE
Multiple organs effected
Minly HEART FAILURE
Which cause CARDIOMYOPATHY in cattle
SCC GuLaM
Gossypol Monensin Lymphosarcoma Selenium/vit. E deficiency--white muscle dz. Cu def.--myocardial fibrosis Cassia
Slaf-ramine
Horse,cattle
Oral irritation—profuse salivation
Due to BLACK PATCH dz. on RED CLOVER
Sluff red black + saliva
Black patch dz. by which fungus
RHIZOC-TONIA
Red clover plant scientific name
TRIFOLIUM
Clove means tri
Aflatoxicosis
A. Flavus , A. Parasiticus
Peanut,soybean
LIVER DAMAGE—jaundice + WS hemorhages
Oak/quer-cus
Has GALLOTANIN
GIT damage + KIDNEY damage
GOATS most resitant
Oak is aka
Quercus
__________ ,__________ ,__________ seen in inophore tox.
Heart damage
Colic
Myoglobin-uria
Zinc deficiency
--parakeratosis Excess keratinization No itching Ventral abdomen,limbs Dd: exudative dermatitis(but seen in YOUNGER SUCKLING PIGLETS)
Exudative dermatitis
Aka greasy pig dz.
CO= staph. HYI-CUS
SUCKLING piglets
DD of zinc def. in pigs
Greasy pig dz./exudative dermatitis
Occur in SUCKLING piglets
In both, lesions on ventral thorax + limbs
__________ poisoning — Cu def.
Mo
Ponderosa pine
- Most sensitive=CATTLE
- LATE TERM ABORTION(3rd trimester)
- TP= ISO-CUP-RESSIC acid—vasocontriction—no blood to uterus+ necrosis of CL—no progestrone
- 3 kg 3 days 3 weeks abortion
- before abortion= edema of vulva and udder+ mucoid vaginal discharge
- if born , calf week & mom dont produce milk
- common in winters
4-ipomeanol tox.
- aka MOLDY SWEET POTATO
- dd: ABPEE/FOG FEVER
- edema of lungs seen
ABPEE
- Acute bovine pulmonary emphysema and edema
- TP= L-TRYPTOPHAN—3-METHYL-LINDONE in body—-lungs damaged
Arsenic tox.
E=Ant baits , wood preservatives ,thi-acetars-emide
CS= GIT hemorhage + diarrhoea
Rx= DIMERCAPROL (deep IM)
What is thi-ace-tars-amide
- A heart work adulticide
- Composed of arsenic—high dose lead to ARSENIC tox.—GIT bleeding
- replaced by MELARSOMINE
Pentachlorophenol is __________ ,__________
Fungicide
Molluscide
__________ is found in SNAIL BAITS
Met-aldehyde
PARA-DI-CHLORO-BENZENE
PDCB
- in diaper,deo
- CNS signs + SALIVATION
Toad poisoning in dog
- profuse saliva+ head shaking+ pawing at mouth
- eg: toad like BUFO MARINUS
Will look like rabies
RAISIN & GRAPES in dog
ANURIC RENAL dz.
Salmon poisoning
Occur 1 week after eating fish which ate a fluke which contained parasite NEO-RICKETSIA HEL-MINTHOCA
severe GI signs + bloody diarhoea
Guess which metal tox. ?
Arsenic
Urea
Bovine bonkers
Tremors
Rx= vinegar
Lead
CNS signs–blindness
Constipation or diarrhoea
Cantharidin
- a horse dz.
COLIC + KIDNEY damage—-blood in urine
Chlorinated hydrocarbons
Eg= lindane, methoxychlor
CNS depress or excite —daure
Trichothecene
- A fungal toxin. (Dz. ka STACHY-BOTYRO-toxicosis)
- VOMIT + IMMUNOSUPRESION
Vomit + immunosupresion
Tricho-the-cene
Goitrogenic plants include __________ ,__________ ,__________ ,__________ ,__________
Soybean Cabbage Rape Kale Turnip
Sc of BRACKEN FERN
Pteridium aqui-linum
Sc of chokecherry
Prunus virginia
Avocado sc
Persea americana
Oleander sc
Nerium oleander
Milk vetch sc
Astargalus flavus
Aka locoweed
Lok milk star ox
Swainsonine
- In astargalus,oxytropis
- CNS signs(circling too)
- predispose to HIH MOUNTAIN dz.
Astargalus and oxytropis aka
Locoweed , milk vetch
Loc milk star ox
Damag kharab te saah di problem
Chokecherry has __________
Cyanide
CYANIDE kha ke PRAN gae te CHOKE hoi
Bracken fern contain __________
Thiaminase
BRA te TEER vala tattoo on THIGH
Oleander has __________ glycosides
CARDIAC
Desi LOCOWEED
Lock milk star ox
Dimag kharab te saah kharab
Locoweed predipose to __________ disease
High mountain dz/brisket edema
Ponerosa pines cause __________
Abortion
Permethrin toxicity
-in flea dip
-HYPERSALIVATION + CNS signs + VD
-dd= OPP, carbamate. (NO MIOSIS in it)
Rx= METHO-CARBAMOL(a MR)
Atropine is not effective && no MIOSIS is seen
D-limonene
Anti-flea med
—vomit in dogs
__________ crystals seen in ETHYLENE GLYCOL tox.
Calcium oxalate MONOHYDRATE(6 sided prism)
After 3 hr in Cat
After 6 hr in Dog
Ethylene glycol tox.
- DRUNKEN GAIT—quiet—PU/PD—OLIGURIA
- BW= azotemia,acidosis,hyperosmolar serum
- UW=flattened hexagon/picket fence board CRYSTALS
What can cause flase +ve in ethylene glycol kit?
If products containining PROPYLENE GLYCOL are given before eg: VALIUM , CHARCOAL
__________ ,__________ ,__________ cause BM supression
Girseofulvin
Chloramphenicol
Sulfonamide
__________ ,__________ ,__________ are teratogens
Griseofulvin
Ketaconazole
Doxorubicin
Rx of ARSENIC tox.
DIMERCAPROL (BAL)
Also give SDOIUM THIOSULFATE IV—-maintains renal function
Why arsenic poisoning look like parvo?
V+ bloody diarrhoea
Cat with VD+HYPERSALIVA+CNS signs
Desi. Rabies signs with ULTI & TATIA
FLEA DIPS(permethrin) Rx: metho-carbamol
Pregnant ruminant eat LUPINE plant=
Arthro-gryposis in child
Adult ruminant eat lupine plant=
CONVULSION—DYSPNOEA—res. Failure—-death
Lupine infected with fungus PHOMOPSIS=
Hepatic damage
Swainsonine is found in __________ ,__________
Oxytropis
Astargalus
Desi= loc milk star ox—-SWAN
Dimag kharab te saah kharab
OP/carbamate tox.
- SLUDDE
- dx: low ACHE levels
- rx: ATROPINE(for muscarinic signs) , 2-PAM(for nicotinic signs)
OP inhibit reversibily
Carbamate inhibit irreversibly
SLUDDE stand for
Saliva Lacrimation Urination Defecation Dysponoea Emesis
Desi= je animal de HAR MORE CHO FLUID NIKAL rea te what is diagnosis?
OP/CARBAMATE
I.e. SLUDDE
Rx: atropine,2-PAM
Mare resproductive loss syndrome
-E=cherry tree, caterpillers
SC of cherry tree is PRUNUS AVIUM
V+PU/PD+CNS(knuckling,decreased reflexes)
What did dog eat?
Antifreeze
Desi= HALKAE kute nu ANTIFREEZE do, fer oh PAANI pe lu ga par ohnu VOMIT a jau gi
Molluscicide
- eg= metaldehyde
- CNS signs+TC+HYPERTHERMIA
Bukhar +heart beat TEZ + CNS signs
Dog ne ki khada?
Molluscicide
Desi=AMOLAK da ias clear nai hoea, fer BUKHAR ho geya— HEART BEAT TEZ ho gai te PAGAL ho gea
Cu toxicity
- Gun metal kidney—port wine urine
- GE–JAUNDICE–SHOCK
Desi= mini COOPER de bonet te GUN jehde cho WINE di bottle nikal di, driver seat te FATEH te naldi seat te JASWANT jehre BIJLI farhi
Memorise lead
Lead vali pencil khadi, AKH thani ho ke DIMAg ch vargi—DIMAG te AKHA dove kharab
Remember arsenic
ARY nu PARVO bohot hundi
Use Ca-EDTA to chelate __________
Lead
Amitraz antidote
Yohimbine
Rx pralidoxime for
OP/carbamate
Desi= OP soni ne CAR ch PRALI ladi
Rx methocarbamol
Permethrin
Desi= PARI MATH sikhaundi
Rx 4-MP/FOMEPIZOLE
ETHYLENE GLYCOL
Desi=je ANTIFREEZA khada te ohnu AMPLIFIER te FEEM khavao
Acetaminophen toxicity in cat
- METHEMOGLOBINURIA+METHEMOGLOBINEMIA+HEINZ BODY ANAEMIA
- dd= IMHA,ITP,anticoagulant,hemobartonellosis
Desi= cat ne TYLENOL khali te ohnu METHI te HONEY do
Case scenario of ACETAMINOPHEN tox. In CAT
Brown blood—DARK MUCUS MEMBRANE
BROWN URINE
HEAD and FEET SWOLLEN +++
Vomit & abd. Pain (general in toxicity) +
Other signs except brown urine & brown mm in TYLENOL poisoning in cat?
Swollen head & limbs
V + abd. Pain
EASTER LILY tox. In CAT
- ACUTE RENAL FAILURE—-V+PU/PD
- BT= AZOTEMIA + high K + high P
Which animal is most sensitive and most resitant to salt poisoning?
Most resistant is SHEEP
Most sensitive in PIG
Rx protocol for ACETAMINOPHEN tox. In CAT
-vomit—gastric lavage—IV fluid—-N-acetylcysteine
Monitor methb Q 2 hr (>50%=[prognosis grave)
If liver enz. High increase within 12 hr—SERIOUS CONCERN
USUALLY SIGNS PERSIST for 1 day
50 mg tab is TOXIC
Cu def. / Mo tox.
ACHROMOTRICHIA—-depigmented hair
PEAT SCOURS/TEART—– diarrhoea with bubbles
Decreased fertility + lameness
__________ ,__________ ,__________ contain PYRO-LIZIDINE alkaloids
Senecio,crotalaria,amsinkia
-LIVER DAMAGE
Desi+ CENA ne SINK ch COAT ute PAER rak ke LIVER nal dhote
White muscle dz.
-Vit.E/selenium def.
-young a
-vigrous exercise—dyspnoea—–sudden death
DUE TO MYOCARDIAL Dz.
-stiff gait+arched back+ recumbent but BAR(bright,alert,responsive)
Death due to enterotoxemia in calf
Bloody diarrhoea+convulsion+opisthonous
Dd: white muscle dz.(i.e. SUDDEN DEATH)
Amsinkia is SC of __________
Yellow tarweed
Crotalaria is Sc of __________
Rattleweed
senecio is SC of __________
Ragwort
Ammoniated feed toxicity
- bovine bonkers
- CNS signs+colic/bloat+dyspnoea
- SMELL of AMMONIA in RUMEN GAS
TREMORS in FACE SEEN
In pseudorabies you see __________ & __________
Itching
Salivation
TEME
- haemophilus somnus
- RES+CNS(+blind,opisthonus)+septic ARTHRITIS
Memorise TEME
haemophilus somnus effect all serous membranes
- pleural cavity—-cough,dyspnoea
- meninges—-CNS signs
- synovial joinr—-arthritis
Desi= HEMA di TEAM in ipl
CNS signs + BLOAT/COLIC + dyspnoea
What has cattle eaten?
Urea/ammoniated feed
Poliencephalomalacia
Star gazing+opisthonus+head pressing +ataxia
Desi= rx is SOHA ali khan nu bulao
Nitrate poisoning
Methhemoglobinemia
Normal in feed < 10,000 ppm
Normal in blood <10ug/ml
Mm color in cyanide poisoning is _________ due to _________
BRIGHT RED
Cyanohb
Cattle death due to BLUE green algae
Death near water sourse
Brady+salivation
Redwater dz.
Clostridium hemolyticum
Intravascular hemolysis–mm icteric , plasma red , urine brown
HEMOGLOBIN in urine
Chocolate tox. In dogs
- TP=methyl-xanthines
- EXCITEMENT+SEIZURES+ARRYTHMIAS
- ECG—V-TACH
- if mild= V+D+PU+hyperactivity
- rx=apomorphine for vomit—LIDOCAINE for v-tach—-diazepam for seizure
If diazepam dont work , give PHENO or PENTO SLOWLY IV
How much milk chocolate can kill 7 kg dog
200 gram
50 gram baking choco can do same
Carcinogen in fishmeal is _________
Ethoxy-quin
Bracken fern ingestion lead to _________ and _________
Enzootic hematuria
BM suppression—decrease in all cell lines
Gossypol lead to _______,____,______ toxicities after chronic ingestion
Cardiac
Hepatic
Renal
Poison hemlock/conium maculatum. In CATTLE
- TP=coniine
- MOUSY ODOUR+HINDLIMB weakness+dilated pupil+slow HR & RR
- ingestion by PA——arthrogryposis
-MOUSY ODOUR FROM URINE AND BREATH
Cyanide tox.
- by PRUNUS sp.(cherry,apricot,peach)
- MM RED
- spasms+salivation+high HR and RR
Yellow star thistle/russian knapweed SC is
Centaurea
Desi=YELLOW STAR ch RUSSIANS CENT banaunde ne
Nigropallidal encephalomalacia
- ingestion of CENTAUREA sp.
- only horse effected
- necrosis of neurons in SUBSTANTIA NIGRA and GLOBUS PALIDUS
- aka CHEWING dz.
- face hypertonicity+CURLING of lips+involuntary CHEWING movements
Horse CANT chew, but CAN swallow
Rx: euthanasia
SC of TALL FESCuE
Neotyphodium
Desi= plant ute FISH, piche GURINDER te ohnu AGG lagi
ABDOMINAL FAT NECROSIS
Aka LIPOMATOSIS
Caused by eating TALL FESCUE
Bracken fern poisoning lead to ________ def. which lead to ________ and ________
Thiamine
Lethargy
Ataxia
SLUDDE + miosis
Suspect what?
OP or carbamate poisoning
Rx: atorpine,pralidoxime(2-PAM)
Horse with POSTERIOR PARESIS,high CK,TACHY,TYING UP
What did it eat?
Ionophore
Greasewood SC is
Sarcobatus
Desi= wood nu GREASE la ke SAR do
-OXALATE poisoning
-bind to Ca in blood—–hypocalcemia
-Ca oxalate stones—-kidney failure
Head lower–seperate from head—excesss saivate with froth—iprog. Incoordination—-coma—death
Plants containing oxalates
Greasewood Sorrel Dock Pigweed Lambsquater
Desi= oxygen needed by PIG & LAMB for DOCKING..end ch GREASE la do
Onion tox. In cats
Oxidative damage to rbc—heinza body anemia
Hb in urine
Dont give garlic and onion
Full rx for antifreeze tox.
Induce vomit—-charcoal , sodium sulfate
IV fluid–diuresis
Treat METABOLIC ACIDOSIS
To prevent metabolism of Eg—give 4-MP
Azaleas(rhodo-dendron)
CARDIAC ARYTHMIA+GASTRIC problem
Desi= AZAM nu ROAD ute ARY. Te GIT prob hui
Water hemlock
Sc=cicuta
Convulsion—death