Toxicology Flashcards
Trichothecene
- Mycotoxin
- Decrease imunity + vomit
- A refuse to eat
Fesceu grass
Lameness + hyperthermia
Zeara-lenone
Estrogenism–vulvovaginitis
__________ prevent overeating of feed containing zeara-lenone
Deoxy-niva-lenol
Fumonisin
Fusarium sp. on moldy corn
Horse— CNS
Pig– high BP + lung edema
In horse ka EQUINE LEUKO-ENCEPHALOMALACIA
In piga ka PORCINE PULMONARY ODEMA
Ergotism
Parasitic fungus i.e. Claviceps purpurea
Ryegrass
Vasocontriction of extremitis—necrosis & gangrene
Pituitary effect—- agalactia
Inophore toxicity in horse
Colic + TC
Tying up—high creatinine kinase+posterior paralysis
Rx of inophore tox.
No antidote
Inophore tox. In CATTLE
Multiple organs effected
Minly HEART FAILURE
Which cause CARDIOMYOPATHY in cattle
SCC GuLaM
Gossypol Monensin Lymphosarcoma Selenium/vit. E deficiency--white muscle dz. Cu def.--myocardial fibrosis Cassia
Slaf-ramine
Horse,cattle
Oral irritation—profuse salivation
Due to BLACK PATCH dz. on RED CLOVER
Sluff red black + saliva
Black patch dz. by which fungus
RHIZOC-TONIA
Red clover plant scientific name
TRIFOLIUM
Clove means tri
Aflatoxicosis
A. Flavus , A. Parasiticus
Peanut,soybean
LIVER DAMAGE—jaundice + WS hemorhages
Oak/quer-cus
Has GALLOTANIN
GIT damage + KIDNEY damage
GOATS most resitant
Oak is aka
Quercus
__________ ,__________ ,__________ seen in inophore tox.
Heart damage
Colic
Myoglobin-uria
Zinc deficiency
--parakeratosis Excess keratinization No itching Ventral abdomen,limbs Dd: exudative dermatitis(but seen in YOUNGER SUCKLING PIGLETS)
Exudative dermatitis
Aka greasy pig dz.
CO= staph. HYI-CUS
SUCKLING piglets
DD of zinc def. in pigs
Greasy pig dz./exudative dermatitis
Occur in SUCKLING piglets
In both, lesions on ventral thorax + limbs
__________ poisoning — Cu def.
Mo
Ponderosa pine
- Most sensitive=CATTLE
- LATE TERM ABORTION(3rd trimester)
- TP= ISO-CUP-RESSIC acid—vasocontriction—no blood to uterus+ necrosis of CL—no progestrone
- 3 kg 3 days 3 weeks abortion
- before abortion= edema of vulva and udder+ mucoid vaginal discharge
- if born , calf week & mom dont produce milk
- common in winters
4-ipomeanol tox.
- aka MOLDY SWEET POTATO
- dd: ABPEE/FOG FEVER
- edema of lungs seen
ABPEE
- Acute bovine pulmonary emphysema and edema
- TP= L-TRYPTOPHAN—3-METHYL-LINDONE in body—-lungs damaged
Arsenic tox.
E=Ant baits , wood preservatives ,thi-acetars-emide
CS= GIT hemorhage + diarrhoea
Rx= DIMERCAPROL (deep IM)
What is thi-ace-tars-amide
- A heart work adulticide
- Composed of arsenic—high dose lead to ARSENIC tox.—GIT bleeding
- replaced by MELARSOMINE
Pentachlorophenol is __________ ,__________
Fungicide
Molluscide
__________ is found in SNAIL BAITS
Met-aldehyde
PARA-DI-CHLORO-BENZENE
PDCB
- in diaper,deo
- CNS signs + SALIVATION
Toad poisoning in dog
- profuse saliva+ head shaking+ pawing at mouth
- eg: toad like BUFO MARINUS
Will look like rabies
RAISIN & GRAPES in dog
ANURIC RENAL dz.
Salmon poisoning
Occur 1 week after eating fish which ate a fluke which contained parasite NEO-RICKETSIA HEL-MINTHOCA
severe GI signs + bloody diarhoea
Guess which metal tox. ?
Arsenic
Urea
Bovine bonkers
Tremors
Rx= vinegar
Lead
CNS signs–blindness
Constipation or diarrhoea
Cantharidin
- a horse dz.
COLIC + KIDNEY damage—-blood in urine
Chlorinated hydrocarbons
Eg= lindane, methoxychlor
CNS depress or excite —daure
Trichothecene
- A fungal toxin. (Dz. ka STACHY-BOTYRO-toxicosis)
- VOMIT + IMMUNOSUPRESION
Vomit + immunosupresion
Tricho-the-cene
Goitrogenic plants include __________ ,__________ ,__________ ,__________ ,__________
Soybean Cabbage Rape Kale Turnip
Sc of BRACKEN FERN
Pteridium aqui-linum
Sc of chokecherry
Prunus virginia
Avocado sc
Persea americana
Oleander sc
Nerium oleander
Milk vetch sc
Astargalus flavus
Aka locoweed
Lok milk star ox
Swainsonine
- In astargalus,oxytropis
- CNS signs(circling too)
- predispose to HIH MOUNTAIN dz.
Astargalus and oxytropis aka
Locoweed , milk vetch
Loc milk star ox
Damag kharab te saah di problem
Chokecherry has __________
Cyanide
CYANIDE kha ke PRAN gae te CHOKE hoi
Bracken fern contain __________
Thiaminase
BRA te TEER vala tattoo on THIGH
Oleander has __________ glycosides
CARDIAC
Desi LOCOWEED
Lock milk star ox
Dimag kharab te saah kharab
Locoweed predipose to __________ disease
High mountain dz/brisket edema
Ponerosa pines cause __________
Abortion
Permethrin toxicity
-in flea dip
-HYPERSALIVATION + CNS signs + VD
-dd= OPP, carbamate. (NO MIOSIS in it)
Rx= METHO-CARBAMOL(a MR)
Atropine is not effective && no MIOSIS is seen
D-limonene
Anti-flea med
—vomit in dogs
__________ crystals seen in ETHYLENE GLYCOL tox.
Calcium oxalate MONOHYDRATE(6 sided prism)
After 3 hr in Cat
After 6 hr in Dog
Ethylene glycol tox.
- DRUNKEN GAIT—quiet—PU/PD—OLIGURIA
- BW= azotemia,acidosis,hyperosmolar serum
- UW=flattened hexagon/picket fence board CRYSTALS
What can cause flase +ve in ethylene glycol kit?
If products containining PROPYLENE GLYCOL are given before eg: VALIUM , CHARCOAL
__________ ,__________ ,__________ cause BM supression
Girseofulvin
Chloramphenicol
Sulfonamide
__________ ,__________ ,__________ are teratogens
Griseofulvin
Ketaconazole
Doxorubicin
Rx of ARSENIC tox.
DIMERCAPROL (BAL)
Also give SDOIUM THIOSULFATE IV—-maintains renal function
Why arsenic poisoning look like parvo?
V+ bloody diarrhoea
Cat with VD+HYPERSALIVA+CNS signs
Desi. Rabies signs with ULTI & TATIA
FLEA DIPS(permethrin) Rx: metho-carbamol
Pregnant ruminant eat LUPINE plant=
Arthro-gryposis in child
Adult ruminant eat lupine plant=
CONVULSION—DYSPNOEA—res. Failure—-death
Lupine infected with fungus PHOMOPSIS=
Hepatic damage
Swainsonine is found in __________ ,__________
Oxytropis
Astargalus
Desi= loc milk star ox—-SWAN
Dimag kharab te saah kharab
OP/carbamate tox.
- SLUDDE
- dx: low ACHE levels
- rx: ATROPINE(for muscarinic signs) , 2-PAM(for nicotinic signs)
OP inhibit reversibily
Carbamate inhibit irreversibly
SLUDDE stand for
Saliva Lacrimation Urination Defecation Dysponoea Emesis
Desi= je animal de HAR MORE CHO FLUID NIKAL rea te what is diagnosis?
OP/CARBAMATE
I.e. SLUDDE
Rx: atropine,2-PAM
Mare resproductive loss syndrome
-E=cherry tree, caterpillers
SC of cherry tree is PRUNUS AVIUM
V+PU/PD+CNS(knuckling,decreased reflexes)
What did dog eat?
Antifreeze
Desi= HALKAE kute nu ANTIFREEZE do, fer oh PAANI pe lu ga par ohnu VOMIT a jau gi
Molluscicide
- eg= metaldehyde
- CNS signs+TC+HYPERTHERMIA
Bukhar +heart beat TEZ + CNS signs
Dog ne ki khada?
Molluscicide
Desi=AMOLAK da ias clear nai hoea, fer BUKHAR ho geya— HEART BEAT TEZ ho gai te PAGAL ho gea
Cu toxicity
- Gun metal kidney—port wine urine
- GE–JAUNDICE–SHOCK
Desi= mini COOPER de bonet te GUN jehde cho WINE di bottle nikal di, driver seat te FATEH te naldi seat te JASWANT jehre BIJLI farhi
Memorise lead
Lead vali pencil khadi, AKH thani ho ke DIMAg ch vargi—DIMAG te AKHA dove kharab
Remember arsenic
ARY nu PARVO bohot hundi
Use Ca-EDTA to chelate __________
Lead
Amitraz antidote
Yohimbine
Rx pralidoxime for
OP/carbamate
Desi= OP soni ne CAR ch PRALI ladi
Rx methocarbamol
Permethrin
Desi= PARI MATH sikhaundi
Rx 4-MP/FOMEPIZOLE
ETHYLENE GLYCOL
Desi=je ANTIFREEZA khada te ohnu AMPLIFIER te FEEM khavao
Acetaminophen toxicity in cat
- METHEMOGLOBINURIA+METHEMOGLOBINEMIA+HEINZ BODY ANAEMIA
- dd= IMHA,ITP,anticoagulant,hemobartonellosis
Desi= cat ne TYLENOL khali te ohnu METHI te HONEY do
Case scenario of ACETAMINOPHEN tox. In CAT
Brown blood—DARK MUCUS MEMBRANE
BROWN URINE
HEAD and FEET SWOLLEN +++
Vomit & abd. Pain (general in toxicity) +
Other signs except brown urine & brown mm in TYLENOL poisoning in cat?
Swollen head & limbs
V + abd. Pain
EASTER LILY tox. In CAT
- ACUTE RENAL FAILURE—-V+PU/PD
- BT= AZOTEMIA + high K + high P
Which animal is most sensitive and most resitant to salt poisoning?
Most resistant is SHEEP
Most sensitive in PIG
Rx protocol for ACETAMINOPHEN tox. In CAT
-vomit—gastric lavage—IV fluid—-N-acetylcysteine
Monitor methb Q 2 hr (>50%=[prognosis grave)
If liver enz. High increase within 12 hr—SERIOUS CONCERN
USUALLY SIGNS PERSIST for 1 day
50 mg tab is TOXIC
Cu def. / Mo tox.
ACHROMOTRICHIA—-depigmented hair
PEAT SCOURS/TEART—– diarrhoea with bubbles
Decreased fertility + lameness
__________ ,__________ ,__________ contain PYRO-LIZIDINE alkaloids
Senecio,crotalaria,amsinkia
-LIVER DAMAGE
Desi+ CENA ne SINK ch COAT ute PAER rak ke LIVER nal dhote
White muscle dz.
-Vit.E/selenium def.
-young a
-vigrous exercise—dyspnoea—–sudden death
DUE TO MYOCARDIAL Dz.
-stiff gait+arched back+ recumbent but BAR(bright,alert,responsive)
Death due to enterotoxemia in calf
Bloody diarrhoea+convulsion+opisthonous
Dd: white muscle dz.(i.e. SUDDEN DEATH)
Amsinkia is SC of __________
Yellow tarweed
Crotalaria is Sc of __________
Rattleweed
senecio is SC of __________
Ragwort
Ammoniated feed toxicity
- bovine bonkers
- CNS signs+colic/bloat+dyspnoea
- SMELL of AMMONIA in RUMEN GAS
TREMORS in FACE SEEN
In pseudorabies you see __________ & __________
Itching
Salivation
TEME
- haemophilus somnus
- RES+CNS(+blind,opisthonus)+septic ARTHRITIS
Memorise TEME
haemophilus somnus effect all serous membranes
- pleural cavity—-cough,dyspnoea
- meninges—-CNS signs
- synovial joinr—-arthritis
Desi= HEMA di TEAM in ipl
CNS signs + BLOAT/COLIC + dyspnoea
What has cattle eaten?
Urea/ammoniated feed
Poliencephalomalacia
Star gazing+opisthonus+head pressing +ataxia
Desi= rx is SOHA ali khan nu bulao
Nitrate poisoning
Methhemoglobinemia
Normal in feed < 10,000 ppm
Normal in blood <10ug/ml
Mm color in cyanide poisoning is _________ due to _________
BRIGHT RED
Cyanohb
Cattle death due to BLUE green algae
Death near water sourse
Brady+salivation
Redwater dz.
Clostridium hemolyticum
Intravascular hemolysis–mm icteric , plasma red , urine brown
HEMOGLOBIN in urine
Chocolate tox. In dogs
- TP=methyl-xanthines
- EXCITEMENT+SEIZURES+ARRYTHMIAS
- ECG—V-TACH
- if mild= V+D+PU+hyperactivity
- rx=apomorphine for vomit—LIDOCAINE for v-tach—-diazepam for seizure
If diazepam dont work , give PHENO or PENTO SLOWLY IV
How much milk chocolate can kill 7 kg dog
200 gram
50 gram baking choco can do same
Carcinogen in fishmeal is _________
Ethoxy-quin
Bracken fern ingestion lead to _________ and _________
Enzootic hematuria
BM suppression—decrease in all cell lines
Gossypol lead to _______,____,______ toxicities after chronic ingestion
Cardiac
Hepatic
Renal
Poison hemlock/conium maculatum. In CATTLE
- TP=coniine
- MOUSY ODOUR+HINDLIMB weakness+dilated pupil+slow HR & RR
- ingestion by PA——arthrogryposis
-MOUSY ODOUR FROM URINE AND BREATH
Cyanide tox.
- by PRUNUS sp.(cherry,apricot,peach)
- MM RED
- spasms+salivation+high HR and RR
Yellow star thistle/russian knapweed SC is
Centaurea
Desi=YELLOW STAR ch RUSSIANS CENT banaunde ne
Nigropallidal encephalomalacia
- ingestion of CENTAUREA sp.
- only horse effected
- necrosis of neurons in SUBSTANTIA NIGRA and GLOBUS PALIDUS
- aka CHEWING dz.
- face hypertonicity+CURLING of lips+involuntary CHEWING movements
Horse CANT chew, but CAN swallow
Rx: euthanasia
SC of TALL FESCuE
Neotyphodium
Desi= plant ute FISH, piche GURINDER te ohnu AGG lagi
ABDOMINAL FAT NECROSIS
Aka LIPOMATOSIS
Caused by eating TALL FESCUE
Bracken fern poisoning lead to ________ def. which lead to ________ and ________
Thiamine
Lethargy
Ataxia
SLUDDE + miosis
Suspect what?
OP or carbamate poisoning
Rx: atorpine,pralidoxime(2-PAM)
Horse with POSTERIOR PARESIS,high CK,TACHY,TYING UP
What did it eat?
Ionophore
Greasewood SC is
Sarcobatus
Desi= wood nu GREASE la ke SAR do
-OXALATE poisoning
-bind to Ca in blood—–hypocalcemia
-Ca oxalate stones—-kidney failure
Head lower–seperate from head—excesss saivate with froth—iprog. Incoordination—-coma—death
Plants containing oxalates
Greasewood Sorrel Dock Pigweed Lambsquater
Desi= oxygen needed by PIG & LAMB for DOCKING..end ch GREASE la do
Onion tox. In cats
Oxidative damage to rbc—heinza body anemia
Hb in urine
Dont give garlic and onion
Full rx for antifreeze tox.
Induce vomit—-charcoal , sodium sulfate
IV fluid–diuresis
Treat METABOLIC ACIDOSIS
To prevent metabolism of Eg—give 4-MP
Azaleas(rhodo-dendron)
CARDIAC ARYTHMIA+GASTRIC problem
Desi= AZAM nu ROAD ute ARY. Te GIT prob hui
Water hemlock
Sc=cicuta
Convulsion—death
Horsebush
Sc=tetradymia
Liver damage—photosensitization
BIG HEAD
Larkspur
Sc=delphinium
BLOAT + salivation
False hellbere
Sc= veratum
Weak muscle+paralysis
Brady+dyspnoea
CONGENITAL CYCLOPS in LAMBS
Desi= HELL ch sare muscle paralysis i.e. HEART,DIAPHRRAGM,SKELE. M
Dark chocolate blood in which poisonining?
Nitrate
Garlicky odour in _____ toxicity
Selenium
Selena nu garlic pasand
Mouse like odour in ______ toxicity
Poison HEMLOCK(conium sp.)
HEMA malini de CAN ch MOUSE
Alkali disease aka
Selenium toxicity
Blind staggers aka ______
Selenium toxicity
Selene STAGE ton dig ke BLIND ho gi, ohnu ALLI ne bachaea
Milk sickness by eatng ________ plant
White snakeroop(eupa-tropium sp.)
Crooked calf syndrome by eating _____ plant at _____ gestation age
- LUPINE
- 40-70 days
Limberleg caused by ______ plant
ACAIA sp.
Bright blindness:
- seen in _____ species
- by eating ______ plant
- SHEEP
- Bracken fern
Ptaquiloside in bracken fern causes renital atrophy in sheep ka ______
Bright blindness
3 plants causing thiamine deficiency in horse?
- bracken fern
- horse tail
- scouring RUSH
Brock ne thigh khadi, ohde tail ug gi te rashs ho ge
Copper toxicity is genetic in _____ dog breeds
Bedlington terriers
Which species is most predisposed to COPPER toxicity?
Sheep
COPPER build up in ____ organ in toxicityq
Liver
Cu toxicity cause _____ crisis
HEMOLYTIC
3 plants causing Cu toxicity?
- Senecio
- Trifolium
- Heliotropium
Senecio aka ______
Ragweed
CENA RAG paunda
Trifolium causes _______ and ______
- Cu toxicity
- Estrogenism
Cyanide found in which 3 grasses?
- johnson grass
- sudan grass
- white clover
Toxic chemical in CYANIDE plant?
PRUSSIC ACID
Cyanide combine with _____ in CYTOCHROME OXIDASE in cells
Fe
I.e. IRON
Tell the condition:
- BRIGHT RED BLOOD
- CHOCOLATE BLOOD
- CYANIDE
- NITRATE
_____ smell in rumen in cyanide poisoning
BITTER ALMOND
_____ test increase in ANTICOAGULANT RODENTICIDE poisoning
PT
Shape of crystals form in antifreeze toxicity
MALTESE CROSS
2 rx for CARBAMATE toxicity?
- ATROPINE
- ALLOXINE
ALLOXINE is Rx for ________
CARBAMATE toxicity
ALLOXINE is __________
Cholinestrate reactivator
OPP compounds have _____ and _____ in name
THION
PHOS
Highest concentration of LEAD in _____ organ
KIDNEY
What is diagnostic value of lead in kidney for toxicity?
> 4 PPM
Rx for LEAD toxicity?
- Ca EDTA
- thimine
NITRATE is not found in grains of plant. T/F
T
Rx for NITRATE toxicity?
METHYLENE BLUE
METHYLENE BLUE IS rx for _______
NITRATE toxicity
Place to take diagnostic sample for NITRATE toxicity?
OCULAR FLUID
PCB and DIOXINS are ______
Halogenated cyclic hydrocarbons
2 plants causing abortion?
- astargalus
- ponderosa pine
A plant that cause ABORTION and CONTRACTED TENDON?
Astragalus
Subteranean clover cause _______
Estrogenism
Subteranean clover scientific name is _______
Trifolium repens
Name 5 plants which are teratogens?
- veratrum(false hellebore)
- lupine
- conium(hemlock)
- astragalus(locoweed)
- tobaco
Tobaco as teratogen cause ___ and _____
- arthrogryphosis
- twisted limbs
Lupine as teratogen cause _______
Crooked calf
These are caused by:
- cyclops=
- crooked calf=
- false hellebore
- lupine
Conium/hemlock as teratogen cause ______
-arthrogryposis
Astragalus/locoweed as teratogen cause ______ and ______
- arthrogryposis
- conracted tendon
Tobaco,hemlock,locoweed cause ARTHROGRYPOSIS. T/F
T
Buckwheat and St. john wort cause ________
Photosensitization
Cyanide in which type of fruits?
Prunus/pitted fruits
Which grasses have cyanide?
- johnson grass
- sorghum
- corn
Which large tree has cyanide?
Eucalyptus
Which berry has cyanide?
Elder berry
_____foot and _____ clover has cyanide
- Bird
- white
Meth-hemoglobinemia is caused by _____ toxicity
-Nitrate
Name 5 plants which cause nitrate poisoning?
- amaranthus
- oats
- corn
- beet
- lamb quater
- sorghum
Which plant cause bleeding?
Sweetclover
Scientific name of sweetclover is ______
Meli-lotus
TP in sweetclover is _______
-dicoumarol
Name 3 plants causing hemolysis
- red maple
- onion
- brassica
SN of red maple
Acer rubrum
Brassica include _____ and _____
- canola
- rapeseed
TP in onion is ____
N-propyl disulfide
TP in brassica is ______
S-methyl cystine sulfoxide
Brassica cause _____
Hemolysis
Brassica and acer rubrum form HEINZ BODY . T/F
T
Name a plant which cause BM depression
-Bracken fern
Canola cause _______ formation and ______ problem
- heinz body
- lung
2 TP in bracken fern?
- ptaquiloside
- thiaminase
3 plants which cause pulmonary toxicity?
- Brassica
- sweet potato(ipomea)
- purple mint(perilla)
_____ mint cause pulmonary toxicity
Purple
*purple mint ka perilla
Digitalis is ______toxic
Cardio
Name 4 plants which have digitalis and cause heart problem?
- foxglove(digitalis purpurea)
- dogbane
- oleander
- lily of valley(apocynum)
Name 2 plants which have “DIGITALIS like” effect?
- monkshood(aconitum)
- milkweed
*cardiotoxic + GI signs
Aconitum is SN for ______
-monkshood
Name 2 misc cardiotoxic plants
- yew(taxus)
- death camus
Which part of yew is not cardiotoxic?
Fruit
TP in taxus/yew
Taxine
Which 2 plants cause ALTERED PERIPHERIAL CIRCULATION?
- tall fescue
- black walnut(juglans nigra)
Black walnut and tall fascue cause circulation problems. T/F
T
SN for black walnut
Juglans nigra
Black lameness cause ____ in horse
LAMINITS
Tall fescue SN is ______
-acremonium
Tall fescue cause _____,______ and _______
- summer syndrome
- fescue foot
- bovine fat necrosis
Andro-medo-toxicosis has effect similar to ______
-digitalis
Ando-medo-toxicosis is caused by which 3 plants?
- kalmia(calf kill,lamb kill)
- pierus japonica
- rhododendron
TP in oak/quercus
Gallotoxin
Oak is _____toxic
Nephro
Name 4 plants which are nephrotoxic?
- oak
- oxalate containing plants
- vit. D containing plants
- amaranthus
- lily
SN of amaranthus?
Pigweed
amaranthus cause _____ and _____ poisoning
- oxalate
- nitrate
Gallotoxin in _____
Oak
Oxalate and nitrate are present in ______ plant
Amaranthus/pig weed
Which plant cause nephrosis?
Amaranthus
3 main plants containing OXALATE?
- lamb quarter
- beet
- rhubarb
3 plants containing vit. D?
- cestrum(jessamine)
- trisetum(golden oats)
- solanum
Toxic principle in cestrum,trisetum,solanum is ______
Calcitriol
3 plants causing secondary photosensitization?
- agave
- lantana
- tetradymia(horsebush)
*ag lan tati
Lupine is aka ______
Bluebonnet
Bluebonnet is aka ____
Lupine
Lupine has a neurotoxin and a reprotoxin. T/F
T
2 TP in LUPINE?
- quino-lizidine
- anagyrine
Lupine cause _____ syndrome
Crooked calf
Crooked calf syndrome is caused by _____
Lupine
3 features in crooken calf syndrome?
- torticollis
- carpal flexure
- scoliosis
When should a pregnant cattle eat LUPINE to cause CROOKED CALF SYNDROME?
-day 40-70
Two plants causing muscle weakness?
- sorgum/sudan grass
- cassia/coffe senna
Sorghum is aka ______ and ______
- sudan grass
- johnson grass
TP in sorghum?
-B cyano alanine
B cyano alanine is present in _______
Sorghum
Sorghum cause _____ syndrome
-equine sorghum cystitis ataxia syndrome
Cassia is aka _____ and _____
- sickepod
- coffe senna
Cassia cause _______
Muscle necrosis
Which plant cause muscle necrosis?
Coffee senna/cassia
Name 4 plants which are GI toxicants?
- buttercup
- castor bean
- stinging nettle
- mustard
Name 2 plants which have NEUROMUSCULAR effects?
- conium/poison hemlock
- delphinium/larkspur
Conium aka _______
Poison hemlock
Delphinium aka ______
Larkspur
Poison hemlock and larkspur have nicotinic effects. T/F
T
What is TERATOGENIC efect of poison hemlock?
- crooked limbs
- cleft palate
____ odour from leaves of conium/poison hemlock
Mouse like
_____ family plants have antiACHE affects
- nightshade family
* tomato and groundcherry too have
3 plants which have anti-cholinergic effect?
- deadly and black nightshade
- jimson weed
- potato
White snakeroot SN is ______
-eupatorium
TP in WHITE SNAKEROOT?
Trematrol
White snakeroot cause ______ sickeness
Milk
2 effects of white snakeroot?
- CNS depressant
- cardiac effect(CHF)
Eupatropium cause CNS depression and CARDIAC problem. T/F
T
3 toxic principles in astragalus?
- miserotoxin
- swainsonine
- selenium
Miserotoxin in locoweed cause ________ condition
CRACKED HEEL
Selenium in locoweed cause _____ and ______
- alkali disease
- blind staggers
3 plants which cause seizures?
- milkweed(+cardiac problems)
- cicuta/water hemlock(resemble strychinine)
- dicentra(breech)
_____- cause exostosis an mottled teeth
Fluride
Inorganic arsenic effect _____ and _____ system
- cardiac
- GIT
Rx for inorganic arsenic?
- DSMA
- DMPS
Which is more toxic?
- organic arsenals
- inorganic arsenals
-inorganic
Two type of organic arsenals?
- aliphatic(thiacetarsemide)
- aromatic(feed additive)
Organic arsenals cause _____ dz
Demyelinating NEURO
C$ of organic arsenicals?
- posterior paresis
- blindness
*BAR
Blue green algae is ______bacteria
Cyano
SN of blue green algae?
-microcytis aeruginosa
Toxins in blue green algae?
- ana toxin
- saxi toxin
Anatoxin and saxitoxin are present in blue green algae. T/F
T
Monogastrics are more sensitive to blue green algae. T/F
F
*monogastrics are less resistance
Animals that survive blue green algae cause ___________
Secondary photosensitization
Meli-lotus is sweetclover. T/F
T
MOA of STRYCHNINE
Inhibits GLYCINE
*glycine is inhibitory neurotransmittor
Strychnine cause ______ type of muscle problem
Tetanic
Strychnine cause death by ______
-asphyxiation
Sorgum:
- aka
- which fungus grow on it?
- which TP do it form?
- tall fescue
- acremonium
- erotine alkaloid
Sudan grass poisoning:
- which species?
- cause ______ and ______
- horses
- pyelonephritis
- abortions
GARLICKY odor on breath.
Which toxicity?
-selenium
Alkali disease features?
- cracked hooves
* caused by selenium toxicity
Selenium toxicity cause _______ staggers
BLIND
Salt toxicity:
- most sensitive species=
- most resistant species=
- pig
- sheep
Sodium is not TP in salt poisoning. T/F
T
Which species is most susceptible to molybdenum toxicity?
Ruminants
Mercury accumulates in which organs?
- brain
- kidney
- muscle
Mercury cause CNS stimulation or depression?
Stimulation
Rx for mercury poisoning?
DMSA
CNS stimulation and HYPERMETRIA is caused by _____ toxicity
Mercury
Walking disease is caused by ______
Pyrolizidine alkaloids
Walking disease means __________
-hepatic encephalopathy
Fiddleneck,comfrey,senecio,crotalaria have pyrolizidine alkaloids. T/F
T
_____ species is most sensitive to NPN
Cattle
_____ mold is responsible for MYCOTIC LUPINOSIS
-phomopsis
______ occurs in mycotic lupinosis
-hepatic injury—-photosensitization
- _____ occur in mycotic lupinosis
- ______ occurs by eating lupine
- hepatic injury
- crooked calf syndrome
- Walking dz by ________
- alkali dz by ______
- pyrolizidine alkaloid containing plants
- selenium toxicity
Slaframine toxicosis:
- aka _______
- plant=_______
- mold=_________
- slobbers
- trifolium retense(RED CLOVER)
- rhizoctonia(BLACK PATCH DISEASE)
Phomosis mold grow on ______ plant
Lupine
*lupine without phomosis cause crooked calf syndorme
____ poisoning associated with EPIDEMIC HYPERTHERMIA
Fescue
Facial eczema aka _____
Pitho-myco-toxicosis
TP responsible for FACIAL ECZEMA
-sporodesmin
Sporodesmin cause _______toxicosis
Pithomyco
______ occurs in FACIAL ECZEMA
-liver damage—–secondary photosensitization
Black light test for which toxin?
Mycotoxin
Mycotoxicosis is most common in :
- ______
- ______
- _______
- piglets
- poultry
- young calves
HSCAS is Rx for _____
Aflatoxicosis
Nitrite oxidise ferrous to ______
Ferric
Nitrate not in grain. T/F
T
Highest concentration of lead in ____ in body
Kidney
Ca-EDTA is Rx for ______
LEAD
LEAD toxicity is most common in ____ and _____
- dog
- cattle
Trithecocene cause _____,_____,_____
- vomit
- anorexia
- immunosuppression
Which mycotoxin cause immunosuppresion?
Trithecocene