Toxicology 2: Toxidromes Flashcards
A1 opposes what?
B2
Cocaine stimulates what?
A1 A2 B1 B2
Cocaine is what?
sympathomimetic
Smoked cocaine rapidly crosses what?
BBB and alveoli
What is a common manifestation of cocaine toxicity? What else?
CVA (due to HTN)
Intracerebral and subarachnoid hemorrhages
What does cocaine do to the brain?
decrease seizure threshold
What is a common effect of cocaine?
rhabdomyolysis (treat with HCO3)
How do you manage anxiety/psychosis from cocaine?
Diazepam / haloperidol (vit H, low risk of rest depression)
How do you manage tachycardia from cocaine?
observation / diazepam
How do you manage HTN from cocaine?
labetalol
do not use normal BBlocker, it creates unopposed A1
How do you manage seizures from cocaine?
Phenytoin / diazepam / CT scan
Carbon monoxide effect on the blood? What happens
250x affinity for HgB compared to O2, leads to metabolic acidosis due to inadequate tissue oxygenation
How do you treat carbon monoxide poisoning?
Oxygen
What is treated with peritoneal dialysis?
Small, hydrophilic, unbound things (including alcohol)
What is the risk with hemofiltration?
Thrombocytopenia (platelets stick to the filter)
