Toxicology Flashcards
Abiotic Degradation
The breakdown of non-living things, photolysis and hydrolysis
Absorption
The act of being taken up or in, especially the passage of a compound through a surface of the body or into the body, systemic circulation
Ames Test
test for mutagens using bacteria
Anthropogenic
man-made toxins
Aryl hydrocarbon Receptor
Ligand-activated transcription factor present in many cells which links environmental chemical stimuli with adaptive responses, such as detoxification
Bioaccumulation
tendency of a compound to accumulate in the bodies of organisms from the environment
Bioassay
a measurement of the effect of a chemical
Bioavailability
the fraction of a substance available for absorption into a biological system
Bioconcentration Factor
ratio of the concentration of the chemical in the organism and water at equilibrium
Biomagnification
a food chain phenomenon, where by a substance is found at higher concentrations at higher levels of the food chain
Biomarker
a biological event that is indicative of exposure to a toxicant or a class of toxin
Exposure
used to asses the amount of chemical that is present within the body
Effect
used to asses the biological effect to a chemical, measuring how the organism respornded
Susceptibility
used to predict the likely impact of exposure to a chemical, usually by assessing a genetic or metabolic predisposition to how the organism will respond to exposure
Bioremediation
natural processes that help eliminate toxins
Carbamate Insecticides
developed to address DDT’s problem, not very toxic to vertebrates and break down quickly
Dioxin-like chemicals
indoles, flavones, benzoflavones, imidazoles, and pyridines, these compounds are metabolized rapidly, but continuous intake from food may cause similar receptor activation as the background levels of dioxins
Henrys Law
Vapor pressure/water solubility (higher KH = more toxin in air)
Hydrolysis
the reaction of water with the chemical addition of a water molecule to the chemical, often double bonds or causes the release of part of the chemical-replaced by oxygen from water rate of hydrolysis is often affected by temp, light and PH
Hyperaccumulation
the process of uptake, translocation and accumulation of the heavy metals at concentrations higher than the surrounding in different parts of the plant
Botanicals
metabolites that occur in nature like rotenone and black leaf 40
Organophosphate Insecticides
one type of pesticide that works by damaging an enzyme in the body called acetylcholinesterase
Persistence
slow to break down
photolysis
light can be absorbed by some chemical bonds absorbed light increase energy in bond and may break the bond
Direct photolysis
direct effect on the chemical
Indirect photlysis
light-absorbed species and it transfer energy to another chemical - transferred energy causes degradation of the second chemical
phytodegredation
the alteration or breakdown of materials by light
phytoremediation
the use of plants and associated soil microbes to reduce the concentration or toxic effects of contaminants in the environment