Toxicokinetics Flashcards
What is toxicity?
Toxicity is the intrinsic quality of a chemical to produce an adverse effect. It is the capacity to induce teratogenic, mutagenic and carcinogenic effects
What is a dose?
A dose is defined as the amount that ultimately reaches the site or sites of action (tissue, cell, or molecular target)
Xenobiotics need to be absorbed, distributed, bio-transformed, and eliminated. True or false?
True
Which xenobiotics don’t need to be absorbed, distributed, bio-transformed, and eliminated?
Chemicals which act directly at the point of contact
What is absorption?
The process by which toxicants cross body membranes and enter the bloodstream
The main sites of absorption are:
The GIT, lungs, and skin
Other possible sites of absorption are:
The peritoneum, or muscle, if a chemical is administered by special routes
What is the most common route of unintentional exposure to a toxicant (especially for children)?
Accidental ingestion; intentional overdose tends to happen too
What is the condition for poisons in the body to cause injury?
Poisons in the GI tract usually do not produce systemic injury to an individual until they are absorbed
Where exactly in the GI tract does absorption occur?
Absorption of toxicants can take place along the entire GI tract: from the mouth to the rectum.
How are organic toxicants absorbed?
Organic toxicant (acid or base) are usually absorbed by simple diffusion in the part of the GI tract where it exists in its non-ionized form
What is the point of the HH equation?
The Henderson–Hasselbalch equations can be used to determine the fraction of a toxicant that is in the non-ionized form and estimate the rate of absorption from the stomach or intestine
Where are organic toxicants more readily absorbed?
In the part of the GI tract where they exist in their non-ionized form
What does the HH equation tell us about weak organic acids?
According to the HH equation, weak organic acids are mainly present in the non-ionized (lipid soluble) form in the stomach and ionised form in the intestine, thereby more readily absorbed in the former
Factors that affect the HH equation
Surface area and Blood flow rate.
Substances which can be absorbed through the GIT’s numerous specialized transport systems (carrier-mediated)
Sugar, Iron, Calcium, Thallium, Pb, Co, Mn, and drugs like 5-Fluorouracil, β-lactam antibiotics
Most toxicants are absorbed through…
Simple diffusion. Only a few require carrier-mediated transport
Particles and particulate matter can also be absorbed. True or false?
Particles and particulate matter can also be absorbed
Relationship between particle size and absorption
Size is inversely related to absorption. The smaller the size, the higher the rate of absorption.
For instance, powdered arsenic is significantly more toxic than its coarse granular form - ↑ surface area
Characteristics of toxicants affecting their GIT absorption
- Must have sufficient aqueous - lipid partition
- Be relatively non-ionized in most parts (lipid- soluble)
- If a particle, must be of relatively low size
Factors affecting GIT absorption
- Other xenobiotics/toxicants: Cd decreases the absorption of Zn and Cu, Ca decreases Cd absorption, and Mg decreases absorption of Fluoride
- pH – changes by food, Antacids
- GI Motility/residency time within various segments of the GI tract, e.g. the effect of Laxatives/Anti-diarrheas
- Age
- Presence or absence of digestive enzymes, bile acids, and bacterial microflora in the GI tract
- Hepatic first pass effect
Example of how age affects absorption in GIT
- Well water with a high nitrate content produces methemoglobinemia more frequently in infants than in adults.
- Higher pH of the neonatal GI tract is permissive for the growth of bacteria
- Bacteria in the GI tract convert nitrate to nitrite, increasing the risk of methemoglobinemia
Example of how the presence of enzymes, bile acids or bacterial microflora affect absorption
Snake venoms are much less toxic by the oral route relative to intravenous exposure because they are broken down by digestive enzymes
Nitroaromatic compounds are reduced by intestinal microflora to potentially toxic and carcinogenic aromatic amines.
Results of airborne poisons
Death by poisoning
Occupational disease
