Toxicity and Teratogenicity

Question 1

Toxicology

Answer 1

Study of adverse effects from chemical or biological agents.

Question 2

Allergy

Answer 2

Histologic reactions released from the body.

Question 3

Pseudo-allergic Drug Reactions

Answer 3

Type B hypersensitivity, present like a drug allergy but are not immunologic drugs.

Question 4

Carcinogens

Answer 4

Causes normal cell to become neoplastic through oncogenes or tumor suppressor genes.

Question 5

Mutagen

Answer 5

Chemical that causes DNA mutations

Question 6

Teratogen

Answer 6

Chemicals that harm fetus in utero

Question 7

Therapeutic index

Answer 7

LD50/ED50 (The dose at which 50% of the subjects die)/ (The dose at which 50% of the subjects exhibit therapeutic response)

Question 8

Idiosyncrasy

Answer 8

Genetically Determined Drug Toxicity

Question 9

Idiosyncrasy drug examples

Answer 9

Plasma Cholinesterase deficiency: metabolizes succinylcholine and mivacurium
Glucose-6-phosphate dehydrogenase (G6PD) deficiency: used for hemolytic anemia