Toxicities and Tx

Question 1

Acetaminophen

Answer 1

N-acetylcysteine (replenishes glutathione)

Question 2

AchE inhibitors/organophosphates

Answer 2

atropine>pralidoxime

Question 3

Antimuscarinic, anticholinergic agents

Answer 3

Physostigmine (crosses BBB), control hyperthermia

Question 4

Arsenic

Answer 4

Dimercaprol, succimer

Question 5

Benzos

Answer 5

flumazenil

Question 6

B blockers

Answer 6

atropine, glucagon, saline

Question 7

carbon monoxide

Answer 7

100% O2, hyperbaric O2

Question 8

copper

Answer 8

penicillamine (copper pennies), trientine

Question 9

cyanide

Answer 9

hydroxocobalamin, nitrites + sodium thiosulfate

Question 10

Digitalis (Digoxin)

Answer 10

Digoxin-specific antibody fragments

Question 11

Heparin

Answer 11

protamine sulfate

Question 12

Iron (Fe)

Answer 12

Deferoxamine, deferasirox, deferiprone

Question 13

lead

Answer 13

Calcium disodium EDTA, dimercaprol, succimer, penicillamine

Question 14

mercury

Answer 14

Dimercaprol, succimer

Question 15

methanol, ethylene glycol (antifreeze)

Answer 15

fomepizole > ethanol, dialysis

Question 16

methemoglobin

Answer 16

methylene blue, vit. C (reducing agent)

Question 17

Opiods

Answer 17

Naloxone

Question 18

salicylates

Answer 18

NaHCO3 (alk urine), dialysis

Question 19

TCAs

Answer 19

NaHCO3 (stabilizes cardiac cell membrane)

Question 20

Warfarin

Answer 20

Vitamin K (delayed effect), PCC (prothrombin complex concentrate)/FFP (immediate effect)