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IP 155 Biopharm > Tournament 3 > Flashcards

Tournament 3 Flashcards

1
Q

Part of the gastrointestinal tract which serves as a reserve area for the absorption of drugs that have escaped absorption proximally because of their physicochemical properties or their dosage form

A

LARGE INTESTINE

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2
Q

___________ delivery systems place the drug at or near the receptor site

A

TARGETED

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3
Q

This is the formation of a ring-like structure resulting from the interaction between a partial ring of atoms and a metal

A

CHELATION

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4
Q

The extent of ionization may be described by

A

HENDERSON-HASSELBALCH EQUATION

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5
Q

Part of the transdermal drug delivery system that maintains the drug concentration gradient within the device

A

ADHESIVE LAYER

*formulation matrix

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6
Q

The faster the stomach emptying the

A

higher the plasma drug concentration

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7
Q

Which of the following gives the correct order of decreasing rate of absorption?

A

SOLUTION, SUSPENSION, CAPSULE, TABLET

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8
Q

Lying on the left side _________ rate of gastric emptying

A

DECREASES

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9
Q

The _________ of a single dose of a drug is a function of both the rate and extent of absorption

A

EFFICACY

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10
Q

Capsule shells become brittle at low ______

A

HUMIDITY

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11
Q

In modified release dosage forms, this is the rate-limiting step

A

LIBERATION

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12
Q

The in vitro correlate of drug absorption that indicates the time it takes for a solid dosage form to breakdown into small particles, not necessarily solution

A

DISINTEGRATION

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13
Q

Modified release tablets alter the __________ of drug release

A

RATE OR TIMING

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14
Q

For hydrophobic drugs, excessive particle size reduction does not always lead to faster dissolution rate due to formation of

A

AGGREGATES

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15
Q

In ________, the drug is impregnated into a biodegradable or nonbiodegradable material and is released slowly for localized or systemic effect

A

INSOLUBLE MATRICES

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16
Q

Generally, drug-cyclodextrin complexes

A

ARE MORE WATER SOLUBLE

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17
Q

Particle size is __________ related to surface area

A

INVERSELY

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18
Q

Drug dissolution is described by

A

NOYES-WHITNEY EQUATION

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19
Q

This is the ability of a drug to exist in more than one crystalline form

A

POLYMORPHISM

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20
Q

Transport process which is also described as “cell-eating”

A

PHAGOCYTOSIS

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21
Q

This excipient makes powders adhere to each other and form aggregates

A

BINDER

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22
Q

The rate of gastric emptying is the rate-limiting step in the dosage form

A

SOLUTION

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23
Q

The more complication the formulation of a drug product, the greater the potential for __________ problems

A

BIOAVAILABILITY

24
Q

Usually the _____ form dissolves more rapidly than the hydrated form

A

ANHYDROUS

25
Q

In conventional oral dosage forms, this is the rate-limiting step

A

DISSOLUTION

26
Q

The make segments of the gastrointestinal tract differ from one another both anatomically and _____, as well as with respect to secretions and ph

A

MORPHOLOGICALLY

27
Q

Modified release tablets may sometimes result to ______ problem

A

DOSE-DUMPING

28
Q

This part of the gastrointestinal tract is where substance like alcohol, barbital, and aspirin are readily absorbed

A

STOMACH

29
Q

Transport process where drugs are moved by the aid of ATP-dependent pumps

A

TRANSPORTER PROTEINS

30
Q

Transdermal drug delivery systems contain the drug for _______ absorption after topical application to the skin

A

SYSTEMIC

31
Q

This is the ration of drug solubility (at equilibrium) in non-aqueous and aqueous solvent

A

PARTITION COEFFICIENT

32
Q

Better blood supply favors a/an

A

INCREASE IN ABSORPTION OF THE DRUG

33
Q

Tablets have reduced effective area due to _________

A

COMPRESSION

34
Q

An increase in the temperature of food __________ rate of gastric emptying

A

INCREASES

35
Q

Part of the gastrointestinal tract where the epithelial surface area is extraordinarily large because of the presence of villi and microvilli

A

SMALL INTESTINE

36
Q

Transport process where drugs are moved from the mucosa to the serosa

A

CARRIER-MEDIATED

37
Q

This is the ability of a drug to exist as optically active stereoisomers or enantiomers

A

CHIRALITY

38
Q

The rate-limiting step in the bioavailability of a drug is the _________ step

A

SLOWEST

39
Q

Transport process described by Fick’s Law

A

PASSIVE DIFFUSION

40
Q

Usually, the amorphous form has a faster dissolution rate than the ______ form

A

CRYSTALLINE

41
Q

Transport process where drugs are moved uphill against a concentration gradient

A

ACTIVE

42
Q

Fatty food ________ rate of gastric emptying

A

DECREASES

43
Q

This is a species formed by the reversible or irreversible association of two or more interacting molecules or ions

A

COMPLEX FORMATION

44
Q

Which of the following gives the correct order of decreasing rate of absorption?

A

SOLUTION, EMULSION, SUSPENSION, PELLET

45
Q

Anticholinergic __________ rate of gastric emptying

A

DECREASE

46
Q

Transport process where drugs or dissolved materials are engulfed by a cell

A

VESICULAR

47
Q

Modified release tablets are suited for short _________ drugs

A

HALF-LIFE

48
Q

Tablet coating should break down quickly so as not to hinder the drug’s ____________

A

BIOAVAILABILITY

49
Q

Transport process where drugs are moved through tight or narrow junctions between cells or transendothelial channels of cells

A

CONVECTIVE

50
Q

A _________ suspension prolongs gastric emptying, slows down drug dissolution, and decreases absorption rate

A

HIGHLY VISCOUS

51
Q

This kind of drug can easily cross the membrane of the gastrointestinal tract – NONPOLAR
 Most chiral drugs are used as __________ mixtures

A

RACEMIC

52
Q

Bulky materials in the gastric area tend to empty ______ than liquids

A

MORE SLOWLY

53
Q

Enteric coating minimizes contact between the drug and the __________ region

A

GASTRIC

54
Q

This excipient may reduce the wetting of the drug particle

A

LUBRICANT

55
Q

The contents of a hard capsule should not be subjected to high _______ that reduced the effective surface area

A

COMPRESSION PRESSURE

56
Q

The most important site for drug absorption in the GI tract

A

SMALL INTESTINE

IP 155 Biopharm (3 decks)

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