TORCH Flashcards
How is toxoplasmosis transmitted?
fecal contamitation of cat. then eaten by human.
Symptoms in toxoplamsosis?
Jaundice, hepatosplenomegaly Thrombocytopenia, anemia Microcephaly Chorioretinitis Hydrocephalus Intracranial calcifications Seizures
Outcomes of toxoplasmosis?
Psychomotor retardation
Seizure disorder
Visual impairments
What is a toxoplasmotic mother treated with during pregnancy?
Spiramycin
Treatment of infants with toxoplasmosis
pyrimethamine, sulfadiazide,and leucovorin.
What are the typical symptoms of congenital rubella?
- Blueberry muffin spots (extramedullary hematopoiesis), thrombocytopenia
- Cardiac—PDA, peripheral
- pulmonary artery stenosis
- Eye—cataracts
- Congenital hearing loss
- Hepatosplenomegaly
Outcomes of congenital rubella?
Hearing loss
Persistent growth retardation
Microcephaly
Mental and motor retardation
CMV symptoms?
- Hepatosplenomegaly, jaundice
- Periventricular calcifications
- Intrauterine growth retardation
- Chorioretinitis
- Microcephaly
- Herpes simplex
- Congenital syphilis
- Thrombocytopenia
- Hemolytic anemia
CMV outcomes?
- Sensorineural hearing loss
- Neuromuscular abnormalities
- Mental retardation
Herpes simplex symptoms?
Keratojunctivitis, skin (5–14 days),
CNS (3–4 weeks), disseminated (5–7 days)
How to diagnose HSV?
PCR, any body fluid
HSV treatment?
acyclovir
outcomes of HSV?
Microcephaly, spasticity Deafness Blindness Seizure disorder Psychomotor retardation Death
Prevention of HSV in the newborn?
C-section when active disease or visible lesions
Symptoms of congenital syphilis?
Early (birth–2 yrs): snuffles, maculopapular rash (including palms of soles, desquamates),
jaundice, periostitis, osteochondritis, chorioretinitis, congenital nephrosis
Late (>2 years of age): Hutchinson teeth, Clutton joints, saber shins, saddle nose, osteochondritis,
rhagades (thickening and fissures of corners of mouth)
How to diagnose syphilis?
The best initial test VDRL-RPR, both of the serum and of the CSF.
Positive tests should be confirmed with FTA-ABS (most accurate).
Treatment of congenital syphillis?
Penicillin
When is it dangerous to the fetus to acquire toxoplasmosis?
2nd through 6th months of gestation.
What is Greggs triad and which disease?
Cataracts, heart defect and deaffness
Treatment of CMV?
ganciclovir is shown to reduce progression to deafness.
