Topoisomerase Inhibitors

Question 1

List the 4 topoisomerase inhibitors

Answer 1

Etoposide, Teniposide, Irinotecan Topotecan

Question 2

What 2 drugs inhibit toposiomerase I?

Answer 2

Irinotecan and Topotecan (the camptothecins)

Question 3

What 2 drugs inhibit topoisomerase II?

Answer 3

Etoposide and Teniposide (the epipodophyllotoxins)

Question 4

What toposiomerase inhibitor is used for ALL?

Answer 4

Teniposide

Question 5

Topotecan is used to treat what 2 cancers?

Answer 5

Ovarian and small cell lung cancer

Question 6

Etoposide and teniposide belong to what class of topoisomerase inhibitors?

Answer 6

Epipodophyllotoxins (inhibit topo II)

Question 7

What 2 topoisomerase inhibitors are camptothecin analogs?

Answer 7

Irinotecan and Topotecan

Question 8

Which topoisomerase inhibitor is used to treat advanced colorectal cancer, as well as lung, ovarian, cervical, and brain tumors?

Answer 8

Irinotecan

Question 9

How do topoisomerase I and II normally function, and what happens when topoisomerase inhibitors are administered?

Answer 9

They break and reseal DNA to relieve torsional strain (topo I: single strand breaks, topo II: double strand breaks). Inhibitors prevent the resealing, causing permanent DNA breaks

Question 10

What side effects do the topoisomerase inhibitors cause, besides neutropenia and GI irritation?

Answer 10

None that I know of (trick question…)

Question 11

What topoisomerase inhibitor is used to treat testicular cancer, lung cancer, and non-Hodgkin’s lymphoma?

Answer 11

Etoposide

Question 12

List the 2 categories of topoisomerase inhibitors.

Answer 12

Camptothecins and epipodophyllotoxins