topoiomerase inhibitors Flashcards
0
Q
is an aminocoumarin antibiotic which inhibits bacterial gyrase?
A
Novobiocin
1
Q
Quinolones (nalidixic acid and ciprofloxacin)
A
inhibit bacterial type II topoisomerases
2
Q
Daunorubicin and doxorubicin
A
intercalate between the bases and interfere withtopoisomerase activity
3
Q
interacts with N7 on guanine and crosslinks DNA; causes apoptosis ( by adding kinks to DNA)
A
Cisplatin
4
Q
a chemotherapy drug used to treat cancer patients, targets mammaliantopoisomerase II.
A
Etoposide
5
Q
alpha amanitine
A
RNA polymerase II inhibitor
6
Q
ricin
A
inhibits 60S ribosomal subunit
7
Q
DPT (Diphtheria-Pertussis-Tetanus)
A
vaccine
Diphtheria toxin catalyzes the ADP-ribosylation of,
and inactivates, eEF-2. In this way, it acts as a translation inhibitor.
8
Q
colicin
A
cuts 50 b 3’ end of 16srRNA of ecoli
