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Pediatrics > Topisomerase inhibitors > Flashcards

Topisomerase inhibitors Flashcards

1
Q

What do Topoisomerase inhibitors do?

A
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2
Q

What is the brand name of Irinotecan?

A
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3
Q

What is the unique side effect of Irinotecan?

A
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4
Q

What is the active and inactive metabolite of Irinotecan?

A
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5
Q

What is the pathophysiology of delayed diarrhea with Irinotecan?

A
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6
Q

Which medication may help with delayed diarrhea?

A

oral cephalosporin to kill the bacteria that produce ß– enzyme causing reactivation of SN-38

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7
Q

How is Irinotecan eliinated?

A

through the bile

patients with a high bilirubin should? receive a drug reduction (listen to panopto)

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8
Q

How does UGT inducer affect toxicity

A

decrease toxicity or effects of the drug Irinotecan
-also seen in smoker, faster metabolism

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9
Q

How does Topoisomerase II inhibition work?
Which cell cylce is affected?

A
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10
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A
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11
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A
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12
Q

What is the Hallmark toxicity in Anthracyclines?

A

Cardiotoxicity: L<
LVEF

-causes red urine and tears donxorubin, duorubicin

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13
Q

What helps with reducing myelosuppression and cardiotoxicity in patients with LVEF of 50%?

A

Use infusion over Bouls

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14
Q

What is the dose that is associated with an increased risk of cardiotoxicity (HF) with Doxorubicin?

A

Doxorubicin

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15
Q

Which Anthracycline is less cardiotoxic?

A

Liposomal doxorubicin

-more mucositis
-Hand-foot syndrome seen

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16
Q

How does Dexrazoxane work?

A

decreases the free radicals …

17
Q

What is the role of Zinecard?

A

limits cardiotoxicity of doxorubicin

(Zinecard is more aggressively used in children, bc they live longer, more benefits in protecting their hearts)

18
Q

What is the role of Totect?

A

treats anthracycline extravasation

19
Q

Which labs are needed for patients using…

A

-LVEF assessment at baseline (echocardiogram)
-signs of extravasation -> stop the drug and txt with ice

20
Q
A
21
Q

What is the brand name of Paclitaxel?

A

Taxol

22
Q
A
23
Q
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24
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25
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26
Q
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Pediatrics (7 decks)

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