Topical only antifungals

Question 1

Clotrimazole, Miconazole, Tioconazole

Answer 1

Topical azoles, Various formulation for skin and vaginal candidiasis

Question 2

Naftifine

Answer 2

1. MOA: naftifine is a broad spectrum antifungal believed to interfere w/sterol biosynthesis similar to terbinafine
2. SE: burning, stinging, dryness, erythema, pruritis, rash
3. Uses: tinea pedis/cruris/corporis
4. CI: not for opthalmic use, no significant interactions

Question 3

Efinaconazole

Answer 3

1. MOA: similar to other azoles, activity against trichophyton rubrm and mentagrophytes
2. Use: Onychomycosis of toe nales

Question 4

Miconazole Nitrate

Answer 4

1. MOA: similar to other azoles, activity against trichophyton, epidermophyton, microsporum, candida, cryptococcus, aspergillus
2. Use: tinea pedis (4wks), vulvovaginal candidiasis (2 weeks), monistat 7 vaginal tablets (7 days).
3. Miconazole claimed to be superior to Nystatin for yeast infections

Question 5

Clotrimazole

Answer 5

1. MOA: like other azoles,
2. Use: candidiasis
3. SE: burning, local erythema

Question 6

Tolnaftate

Answer 6

1. Activity includes trichophyton, microsporum, M. epidermophyton
2. Use: Effective in tinea pedis, tinea versicolor, not effective vs onychomycosis.