Topic 8.2 Transfer of genetic information Flashcards

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1
Q

Define genotype

A

The genetic constitution of an organism

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2
Q

Define phenotype

A

The expression of an organism’s genetic constition with its interaction with the enviroment

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3
Q

What is an allele?

A

Different froms of a particular gene, found at the same locus (position) on a chromosome. A single gene could have many alleles.

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4
Q

What is meant by a dominant allele?

A

An allele whose charecterisitic will always appear in the phenotype, whether one or two are present.

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5
Q

What is meant by a recessive allele?

A

An allele whose charecterisitc only appears in the phenotype if no dominant allele is present, meaning two must be present.

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6
Q

What is meant by codominant alleles?

A

Two dominant alleles that both contrubute to the phenotype, either by showing a blend of both charecteristics, or the charecteristics appering together

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7
Q

What is meant by homozygous?

A

Both alleles are dominant, or both alleles are recessive.

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8
Q

What is meant by heterozygous?

A

One allele is dominant, the other is recessive.

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9
Q

What is Mendal’s first law, segregation?

A

States that an individual can pass only one allele for a characteristic into a gamete. In a heterozygote there will be an equal probability of this being either of their two alleles.

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10
Q

What is meant by multiple alleles?

A

A gene with more than two alleles

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11
Q

How are non-interacting, unlinked genes inheritited?

A

Can be monohydrid of dihybrid.

  • Monohybrid = a phenotypic charecterisitic is contolled by a single gene
  • Dihybrid = two phenotypic charecterisitics are controlled by two different genes present on two different chromosomes
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12
Q

What is meant by autosomal linkage?

A

Where two or more genes are located on the same (non-sex) chromosome. In this case, only one homologous pair is needed for all four alleles to be present. For genes that aren’t linked, two homologous pairs are needed.

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13
Q

What is Mendal’s second law

A

States that the inheritance of one charecterisitic will have no effect on the inheritance of another. However it has become clear that this only applies when genes are not linked on the same chromosome

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14
Q

Give an example of autosomal linkage

A

Drosophila (fruit flies); colour and wing length are autosomally linked, meaning they are inherited in pairs

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15
Q

Explain why autosomally linked genes are inherited in pairs, referring to mitosis.

A

Genes on the same chromosome, particularly those closest together, are unlikely to undergo recombination during meiosis. Therefore they are inherited as if they were the same gene.

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16
Q

What is meant by sex-linkage? Give an example.

A

Where an allele is located on one of the sex chromosomes, meaning its expression depends on the sex of the individual e.g. haemophilia.

17
Q

Why are males more likely to express a recessive sex-linked allele?

A

Most sex linked alleles are located on the X chromosome. Therefore males only get one copy of the allele, so will express this charecteristic even if it’s recessive. Since females get two alleles, this is less likely.

18
Q

What is the chi2 test?

A

A statistical test to find out whether the difference between observed and expected data is due to chance or a real effect.

19
Q

What are the criteria for the chi2 test?

A
  • Data placed in discrete catagories
  • Large sample size
  • Only raw count data allowed i.e. not %
  • No data values = 0
20
Q

How is chi2 performed?

A

The formula results in a number, which is then compared to a critical value (for the corresponding degrees of freedom). If the number is greater than or equal to the critical value, we conclude there is no significant difference and the results occured to chance.

21
Q

How can we use a chi2 in relation to the content of topic 8?

A

We can compare expected phenotypic ratios with observed ratios to test our understanding of how different genes and alleles are inherited.