TOPIC 7: Genetics, populations, evolution and ecosystems Flashcards
3.7.1 Inheritance
Define genotype.
The genetic consitution of an organism.
(Describes all the alleles an organism has.
Determines the limits within which the charactersitics of an individual may vary.)
3.7.1 Inheritance
Define phenotype.
The expression of the genes and its interaction with the environment.
3.7.1 Inheritance
Define gene.
A section of DNA that codes for a polypeptide that results in a characteristic
3.7.1 Inheritance
Define allele.
Different forms of the same gene.
3.7.1 Inheritance
Define diploid.
When an organism contains 2 copies of one chromosome = 2 alleles for the same gene.
3.7.1 Inheritance
Define haploid.
When an organism contains one copy of a chromosome = one allele for the same gene.
3.7.1 Inheritance
Define dominant alleles.
An allele that will always be expressed in the phenotype.
3.7.1 Inheritance
Define recessive alleles.
An allele only expressed if no dominant alleles is present.
Gg = dominant
gg = recessive homozygous.
There must be 2 recessive alleles for phenotype to be expressed.
3.7.1 Inheritance
Define monohybrid.
Genetic inheritance cross of characterisitcs determined by one gene
3.7.1 Inheritance
Genetic diagram coding of monohybrid.
Single letter
Capital or lower case letters.
example: G or g
3.7.1 Inheritance
What was Gregor Mendel’s study based on?
Study of the colour of pea pods.
Green or yellow.
3.7.1 Inheritance
Outline what pure breeding refers to in Gregor Mendel’s study of the colour of pea pods.
Green pods are bred with green pods continously for the character of green pods.
Give rise to plants with green pods.
Pods = homozygous
3.7.1 Inheritance
Outline what the first filial / F1 generation refers to in Gregor Mendel’s study on the colour of pea pods.
Pure bred Green pods + Pure bred yellow pods = allele for green pods (green pods are dominant)
Parental phenotype: Green pod Yellow pods
Parental genotype:
GP= GG
YP = gg
Gametes:
GP = G G
YP = g g
Offspring genotype:
punnet square using gametes to result in
4 x Gg
Offspring phenotype:
All plants have green pods (Gg)
3.7.1 Inheritance
Outline what the first filial / F1 generation refers to in Gregor Mendel’s study on the colour of pea pods.
Heterozygous plants (Gg) of F1 generation are crossed with another Gg = F1 intercross.
RATIO = G:Y = 3:1 plants.
F1 Offspring phenotype: Green pods Green pods.
F1 Offspring genotype:
GP = Gg
GP = Gg
Gametes:
GP = G g
GP = G g
Offspring F2 genotype:
Punnet square using gametes to result in
1 x GG
2 x Gg
1 x gg
Offspring F2 phenotype:
GREEN PODS ARE DOMINANT SO its a 3:1 ratio = GP:YP
3.7.1 Inheritance
What is the monohybrid genetic cross ratio?
3:1
G:Y
3.7.1 Inheritance
Why are the actual results of genetic crosses rarely the same as the predicted results?
Due to statistical error
Chance that determines which gametes fuses with each other.
Larger the sample = more likely actual results will come near to matching the theoritical one = 3:1
3.7.1 Inheritance
Define dihybrid.
Genetic inhertiance cross for a characteristic that is determined by 2 genes
3.7.1 Inheritance
What was Gregor Mendel’s study on for the dihybrid genetic cross?
Studied 2 characters of pea plants at the same time.
1. Seed shape:
round = dominant
wrinkled = recessive.
2. Seed colour:
yellow = dominant
green = recessive
3.7.1 Inheritance
Outline the genetic diagram coding of the dihybrid cross of Gregor Mendel’s study of the 2 characterisitcs of pea plants.
R = Round seeds
r = wrinkled seeds
G = Yellow seeds
g = green seeds
Roundyellow: RG (dominant,dominant)
Roundgreen: Rg (dominant,recessive)
Wrinkledyellow: rG (recessive,dominant)
Wrinkledgreen: rg (recessive,recessive)
3.7.1 Inheritance
Outline the genetic cross between purely bred round yellow seeds (dominant,dominant) and purely bred wrinkled green seeds (recessive,recessive).
Parental phenotype: Round yellow seeds, Wrinkled green seeds.
Parental genotype:
RY: RRGG
WG: rrgg
Gametes:
RY: RG
WG: rg
Offspring genotype:
RrGg
3.7.1 Inheritance
Genetic explanation of Mendel’s intercross between plants of F1 generation.
4 gametes produced from RrGg:
RG, Rg, rG, rg
Parental phenotype: round yellow, round yellow
Parental genotype:
RY: RrGg
RY: RrGg
Gametes:
RY: RG Rg rG rg
RY: RG Rg rG rg
Offspring (F2) genotype: heterozygous cross
punnet square of the gametes to result in
Offspring (F2) phenotype: heterozygous cross
9 x round yellow
3 x round green
3 x wrinkled yellow
1 x wrinkled green
3.7.1 Inheritance
State the theoritical ratio and the observed Mendel’s ratio.
Theoritical: 9:3:3:1
Observed Mendel’s 315:108:101:32
Theoritical is close enough to the observed results allowing for statistical error
3.7.1 Inheritance
What does the F1 generation produce?
4 gametes = RG, Rg, rG, rg
Gene for seed colour and shape are on seperate chromsomes
Fertilisation is random
3.7.1 Inheritance
Define codominance.
Both alleles are equally dominant and are expressed in the phenotype.
3.7.1 Inheritance
Genetic diagram coding of codominance.
Gene^allele
example: C^R C^W
3.7.1 Inheritance
A cross between a red and white-coated shorthorn cattle.
C^R = allele for red pigment production.
C^W = allele for white pigment production.
HOMOZYGOUS = C^R C^R and C^W C^W
Parental phenotype: Red coat White coat.
Parental genotype: C^R C^R and C^W C^W
Gametes:
C^RC^R = C^R C^R
C^WC^W = C^W C^W
Offspring genotypes:
punnet square of the gametes to result in
Offspring phenotype:
100% roan coat (C^RC^W)
3.7.1 Inheritance
A cross between the roan coated shorthorns. (C^RC^W)
HETEROZYGOUS = C^RC^W
Parental phenotype:roan coat & roan coat
Parental genotype: C^RC^W & C^RC^W
Gametes:
C^RC^W = C^R C^W
C^RC^W = C^R C^W
Offspring genotype:
punnet square of the gametes to result in
Offspring phenotype:
50% = roan coat = C^RC^W
25% = red coat = C^RC^R
25% = white coat = C^WC^W
3.7.1 Inheritance
Define mutliple alleles.
More than 2 alleles for a 1 gene.
3.7.1 Inheritance
Genetic diagram coding of multiple alleles.
Gene^allele
example: I^A I^O
I^B I^O
3.7.1 Inheritance
Outline the antibodies in the plasma and the antigens in the red blood cell of red blood cell group A.
AB in plasma = Anti-B
Antigen in RBC = Antigen A
3.7.1 Inheritance
Outline the antibodies in the plasma and the antigens in the red blood cell of red blood cell group B.
AB in plasma = Anti-A
Antigen in RBC = Antigen B
3.7.1 Inheritance
Outline the antibodies in the plasma and the antigens in the red blood cell of red blood cell group AB.
AB in plasma = none
Antigen in RBC = Antigen A and B
3.7.1 Inheritance
Outline the antibodies in the plasma and the antigens in the red blood cell of red blood cell group O.
AB in plasma = Anti-A and B
Antigen in RBC = none
3.7.1 Inheritance
Outline genotypes of the phenotypes:
Blood group A
Blood group B
Blood group AB
Blood group O
Blood group A = I^A I^O or I^A I^A
Blood group B = I^B I^O or I^B I^B
Blood group AB = I^A I^B
Blood group O = I^O I^O
A = dominant
B = dominant
AB = codominant
O = recessive.
3.7.1 Inheritance
Define autosomal linkages.
Two genes carried on / located on the same chromosome = autosome.
From the chromosome 1-23 the 23rd chromosome = sex chromosome ( X or Y)
3.7.1 Inheritance
What should you assume in autosomal linkages?
NO crossing over
All linked genes remian together in meiosis forming gametes then offspring.
3.7.1 Inheritance
Drosophila fruit fly example of autosomal linkage.
Two linked genes:
1. body colour =
grey = dominant = G
black = recessive = g
2. wing size
normal = dominant = N
vestigial = recessive = n
Grey normal = GN
Grey vestigial = Gn
Black normal = gN
Black vestigial = gn
Parental phenotype: Grey body & Grey body.
Parental genotype:
GB = Gg Nn
GB = Gg Nn
Gametes:
GB = GN & gn
GB = GN & gn
Offspring phenotype:
punnet square using the gametes to result in
Offspring genotype:
3 x fruit flies = grey body and normal wings
1x GGNN 2xGgNn
1 x fruit flies = black body and vestigial wings
1x ggnn
3.7.1 Inheritance
Desribe and explain the ratio of 3:1 in autosomal linkage using the Drosophila fruit fly.
3 fruit flies:
Linked
No crossing over
More common.
1 fruit fly:
Not linked
Crossing over occurs
More rare.
3.7.1 Inheritance
Define sex linkages.
A gene whose locus os on the X chromosome
3.7.1 Inheritance
Genetic diagram coding for sex linkages.
Chromsome^allele
example: X^R X^r
3.7.1 Inheritance
What is X-linked genetic disorder?
Disorder caused by a defective gene on the X chromosome.
3.7.1 Inheritance
What is Haemophillia?
Blood clots slowly.
Slow and persistent leading to internal bleeding.
Lethal if not treated.
Some selective removal of gene population = occurenece = rare = 1 in 20000 in europe
3.7.1 Inheritance
Outline one cause of Haemophillia.
Recessive allel with an altered sequence of DNA nucleotides which codes for a faulty protein = does not function.
Indivduals are unable to produce functional protein required for the clotting process
3.7.1 Inheritance
Inheritance of haemophillia from a female carrier.
H = dominant = allele for the production of clotting protein = rapid blood clot
h = recessive = allele for the non-production of clotting protein = slow blood clot.
} always attached to X chromosome = X^H X^h
Parental phenotype: Carrier female & normal male.
Parental genotype:
CF = X^H X^h
NM = X^H Y
Gametes:
CF = X^H & X^h
NM = X^H & Y
Offspring genotype:
punnet square using the gametes to result in
Offspring phenotype:
25% normal female = X^H X^H
25% normal male = X^H Y
25% carrier female = X^H X^h
25% haemophilliac male = X^h Y
3.7.1 Inheritance
Define epistasis.
One gene influences (affects / masks) the expression of another gene.
example = dihydrid = 2 genes = one masks the other one.
example = coat colour in mice, coat colour in Labradors, fruit colour of vegetables.