Topic 6 - Inheritance, Variation and Evolution Flashcards
What is DNA
-The chemical that all of the genetic material in a cell is made up from.
-It contains coded information
What determines what inherited characteristics you have
DNA
Where is DNA found
In animal and plant cells in long structures called chromosomes
What is the structure of DNA like
It is polymer and is made up of two strands coiled together in the shape of a double helix.
What is a gene
Small section of DNA found on a chromosome
What do genes do
-Each gene codes for a particular sequence of amino acids which are put together to make a specific protein
-Tells cells in what order to put the amino acids together
What does DNA determine
-What proteins a cell produces (e.g. haemoglobin or keratin)
-In turns determines what type of cell it is (e.g. red blood cell or skin cell)
What is a genome
The entire set of genetic material in an organism
Why is understanding the human genome so important for medicine and science
-Allows scientists to identify genes in the genome that link to diseases
-Scientists may be able to develop effective treatments for inherited genes if they knew what genes caused
-Can use genomes to trace the migration of populations of people around the world. Differences in genomes can determine when new populations split off in a different direction and what route they took
What are DNA strands made up of
Repeating units called nucelotides
What does a nucleotide consist of
A sugar, a phosphate group and one base
What do the sugars and phosphate groups in the nucleotides do
Form a backbone to the to the DNA
They alternate
What do bases do in nucleotide
One of four bases - A, T, G or C join to each sugar
What bases always pair with each other (complementary pairing)
-T and A
-C and G
What decides the order of amino acids in a protein
The order of bases in a gene
How many bases code for one amino acid
Three bases
What do amino acids do do after being coded for
The amino acids are joined together to make various proteins all depending on the order of the gene’s bases
What do some non-coding parts of DNA do
Switch genes on and off, so they control whether or not a gene is expressed (used to make a protein)
Where are proteins made?
In cell cytoplasm on ribosomes
Why can’t cells get codes straight from the DNA to the ribosomes
DNA is found in the cell nucleus and can’t move out of it because it’s really big
How does protein synthesise
mRNA is made by copying the code from DNA. The mRNA acts as a messenger between the DNA and the ribosome it carries the code between the two. Once the template is at the cytoplasm the protein will be synthesised, and depending on the template used a different protein will be made. The correct amino acids are brought to the ribosomes in the correct cells order by carrier molecules
How do carrier molecules work?
One side binds to a corresponding amino acids and the other is shaped to fit a specific mRNA. There’s a specific carrier molecule for each protein. The carrier molecule binds to the mRNA. Enzymes link the amino acids together and the carrier is released
Give some examples of proteins and their functions
- Enzymes - act as a biological catalyst to speed up chemical reactions in the body
- Hormones - used to carry messages around the body (e.g. insulin is released into the blood by the pancreas to regulate the blood sugar level.
- Structural proteins - are physically strong like collagen is a structural protein that strengthens connective tissues (like ligaments and cartilage)
What are mutations?
A random change in an organisms DNA
When do mutations occur and what can increase the chance
-They occur continuously and can be spontaneous (e.g. when a chromosome isn’t replicated correctly)
-Exposure to certain substances or some types of radiation can increase the chance
What do mutations do
-They change the sequence of DNA bases in a gene, which produces a genetic variant. This can lead to changes in the protein that the gene codes for
-Most have little or no effect on the protein or some will change it to such a small extent that the function or appearance isn’t affected
What will happen if a mutation seriously affects a protein
It may code for an altered protein with a change of shape so it may not perform its function well (e.g. in enzymes if the active site is changed the substrate won’t fit into it - denaturing)
What happens if there is a mutation in non-coding DNA
It can alter how genes are expressed
What is an insertion mutation
Where a new base is inserted into the DNA base sequence where it shouldn’t be
What effects can insertion mutation have
It can change the amino acids that the three bases code for and can change more then one amino acid as they have a knock-on effect on the bases further on in the sequence
What are deletion mutations and what effect will this have
-When a random base is deleted from the DNA base sequence
-The base sequence will be “read” differently so may code for different amino acids and could have a knock-on effect further down the sequcne
What are substitution mutations
-When a random base in the DNA base sequence is changed to a different base
What is sexual reproduction
Where genetic information from two organisms is combined to produce offspring which are genetically different to either parent
In humans how many chromosomes does each gamete contain
23 - half the chromosomes in a normal cell
What happens during fertilisation
The egg and sperm cell fuse together to form a cell with the full number of chromosomes
How can flowers reproduce sexually
They have egg cells that fuse with pollen
How does asexual reproduction happen
There’s only one parent and it happens by mitosis - an ordinary cell making a new cell by dividing it in two. The new cell has exactly the same genetic information as the parent cell making it a clone.
What reproduces asexually
Bacteria, some plants and animals
How does sexual reproduction produce variation in offspring
Due to two parents the offspring contain a mixture of their parents genes and this mixture produces variation
How do gametes only have half the original number of chromosomes
Because cells divide by meiosis
Outline the process of meiosis
-Cell duplicates it’s genetic information forming two armed chromosomes - one arm of each is an exact copy of the other arm. After replicationthe chromosomes arrange into pairs
-In the first division in meiosis the chromosome pairs line up in the centre of the cell
-The pairs are then pulled apart so each new cell has only one copy of each chromosome
-In the second division the chromosomes line up again in the centre of the cell and the arms of the chromosomes are pulled apart.
What are the products of meiosis
-4 gametes each with only a single set of chromosomes in it. Each of the gametes is genetically different from the others because the chromosomes all get shuffled during meiosis and each gamete only gets half of them, at random.
What happens to the cell produced by gamete fusion
-The cell by mitosis to make a copy of itself.
-This repeats many times to produce lots of new cells in an embryo.
-As the embryo develops the cells start to differentiate into the different types of specialised cell that make up a whole organism
Why does variation caused by sexual reproduction give species a survival advantage
-It increases the chance of a species surviving a change in the environment. The variation may allow some offspring being able to survive in the new environment
What is natural selection and why is it an advantage for sexual reproduction
Individuals with better adapted characteristics for the environment have more chance of survival so they are more likely to breed successfully and pass the characteristics on.
What is selective breeding?
Individuals with a desirable characteristic are bred to produce offspring that have the desirable characteristic too. We can use selective breeding to speed up natural selection.
What are the advantages of asexual reproduction
-There only needs to be one parent so it uses less energy than sexual reproduction as organisms don’t have to find a mage
-Faster than sexual reproduction
-Many identical offspring can be produced in favourable conditions
How does a malaria parasite reproduce
-The parasite is spread when a mosquito bites a human and it is transferred
-It reproduces sexually in the mosquito and asexually when in the human host.
How do fungi reproduce
-Both sexually and asexually when spores are release which become new fungi when landing in a suitable place
-Asexually produced spores are genetically identical to the parent fungus
-Sexually produced spores introduce variation and are often produced in response to a change in the environment
How do strawberries reproduces by both asexual and sexual reproduction
The plants produce ‘runners’ which are stems that grow horizontally on the surface of soil away from a plant and at various points an identical strawberry plant forms
How do plants from bulbs reproduce both sexually and asexually
New bulbs can form from the main bulb and divide off of the plant. Each new bulb can grow into a new identical plant
What chromosomes determine gender
-Out of the 23 pairs, the 23rd pair are labelled either XY or XX and are the two chromosomes that determine sex
-Females have two X chromosomes
-Males have an X and a Y chromosome
What is the probability of each sperm cell getting an X and Y chromosome
50% each as when the sperm is made the X and Y chromosome are drawn apart in the first division in meiosis
What sex chromosomes do egg cells have
Original cell has two chromosomes but after meiosis the eggs have one X-chromosome