Topic 5 - Tablets Flashcards
List 3 types of tablets
- Compressed/multiple compressed
- Effervescents
- Chewable
- Buccal/sublingual
List 2 desired properties of tablets
- Able to withstand stresses of manufacture, transport, handling
- Acceptable to pt
- Provide desired bioavail
Tablet components (6)
- Drug
- Fillers
- Binders
- Disintegrants
- Antifrictional agents
- Miscellaneous
Provide an example of a binder
Gelatin, glucose, starch agar
Provide an example of a disintegrant
Microcrystalline cellulose, carbonates, starch
What are the 2 substances that impact disintegrants (and therefore dissolution)?
Lubricants/anti-adherents and glidants
The 3 tabletting methods
- Dry granulation
- Wet granulation
- Direct compression
List 4 factors impacting powder flow
Adhesion, cohesion, size, shape, density
What can be done to a funnel to facilitate proper tablet production?
Ground the funnel to prevent static electricity from forcing powder particles together. Then shake the funnel to ‘push’ the powder out
Granule
Primary powder particles processed to adhere to larger particles
Why do we granulate?
To improve powder flow in tablet machine
Sieving
Prevents aggregation, improves flow, improves compaction, comes after granulation
Steps to wet granulation
- Drug is ground
- Blended with adjuvants (fillers usually)
- Agglomerates (dough consistency - liquids added here)
- Pelletized into granules
- Dried
- Screened
- Blended with lubricants
- Compressed into tablet
Steps to dry granulation
- Drug is ground
- Blended with adjuvants (fillers usually)
- Pelletized into granules
- Crushed
- Screened
- Blended with lubricants
- Compressed into tablet
Steps to direct compression
- Drug is ground
- Blended with adjuvants (fillers usually)
- Compressed into tablet
