Topic 5 Clinical - Content Flashcards

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1
Q

What is Deviance?

A

Behaviour that is rare and unusual going against social norms

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2
Q

What is Dysfunction?

A

Behaviour that interferes with everyday life/activities

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3
Q

What is Distress?

A

Behaviour causes anxiety and pain

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4
Q

What is Danger?

A

Causing physical or psychological harm to themselves or others

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5
Q

What are the Strengths for the diagnosis of mental disorders?

A

Using all 4D’s may help avoid errors in diagnosis

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6
Q

What are the Weaknesses for the diagnosis of mental disorders?

A

Subjective
- Ratings are being made of feelings - biased by situational, cultural, and historical factors - affects reliability

Labelling
- End up with labels for people with mental health issues (using “danger” assumes mental illness is dangerous - leading to stereotypes - meaning is distorted through the media)

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7
Q

What is a Classification System?

A

MHD (Mental Health Disorder)

Describe clusters of symptoms that define disorders, which should lead to better quality diagnosis.

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8
Q

What’s DSM?

A

DSM = Known as DSM-V (V = 5th edition, DSM-5) or DSM-IV-TR (IV = 4th edition, TR = text revised):

  • DSM-V:
    • Current
    • Linked disorders grouped together
    • Use info from interview + records (like ICD) Sections:
      1. Introductions to the manual with instructions on its use
      2. Classification of main MHD
      3. Future + Other assessment measures, e.g. help diagnoses from diff cultures
  • DSM-IV-TR - Multi-axial tool because of its 5 axes/chapters
    1. Mental Health Disorders (anxiety)
    2. Described symptoms related to personality disorders
    3. Described medical conditions (brain damage) to explain the start of clinical issues.
    4. Described psychosocial/environmental problems that could be involved with MHD’s (loss of housing/employment)
    5. Scale to assess global functioning of an individual (how much a persons symptom affects their day) = score helps with diagnosis + assess need for treatment
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9
Q

What’s ICD?

A

ICD = Currently ICD-10 (10th version):

  • All diseases
  • Section F specific to MHDs
  • Groups each disorder as part of a family, e.g family: mood (affective) disorders includes: depression in all its forms
  • Code: F32 (F=MHD section) (3=Family of MHD) (2=specific disorder, e.g. 2 is depression, 1 is bipolar)
  • Decimal points make categorisation even more specific
  • Guide diagnosis through interview
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10
Q

What’s Reliability of Diagnosis?

A

Reliability - Clinicians agree on the same diagnosis for the same patient

Inter Rater Reliability Test:

- Showing 2+ clinicians the details of a patients case history
- Assess level of agreement between them - if all raters (clinicians) agree on the same diagnosis, high inter rater reliability.
- Early diagnostic symptoms had low inter-rater reliability

Patient Factors:

- Patients give inaccurate info because of memory problems, denial or shame
- Specific issues - disorganised thoughts cause issues

Clinician Factors:

- Subjective judgment - interpretation affected by different background/training or experience
- Unstructured nature of interview - Lead to clinicians focusing on different symptoms (nightmares or traumatic past event) - Thus different info gathered - different diagnosis
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11
Q

What’s Validity of Diagnosis?

A

Validity - A diagnosis genuinely reflects the underlying disorder

  • Construct Validity - Whether a measure is actually measuring the thing its supposed to
  • Concurrent Validity - Comparing a new test with an existing test to see if they have similar results, which is done at the SAME time.
  • Predictive Validity - Results from a test such as DSM or a study can predict future behaviour
  • Convergent Validity - 2 tests have a strong relationship that measure the same thing

Convergent - 2 measures measure the same thing whilst Concurrent/Predictive there can be a different way of measuring each studies.

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12
Q

What’s the strengths for Validity of Diagnosis on DSM?

A

Kim Cohen et al. (2005)

- Looked at the behaviour of children diagnosed with conduct disorder to see whether those children were more likely to report their own antisocial behaviour and be disruptive during assessment.
- These behaviours would be expected if their diagnosis was valid. The results of the study did find validity in the diagnosis.

Lee (2006):

- Teachers opinion about a child was compared with an ADHD diagnosis using the DSM-IV-TR
- Was found that there was a match between the measures, so the DSM was valid
- However, boys fit the DSM criteria better than girls - ---- - Studies show that the DSM is valid in diagnosis. Different mental health issues were chosen in the different studies cited, which reinforces this conclusion. - Claim that the DSM is valid is supported by the claim its reliable, as reliability and validity go together. If the DSM is not reliable, it will not be valid.
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13
Q

What are the weaknesses for validity of diagnosis using DSM?

A

Co-morbidity = having more than one mental disorder/illness or disease

Reductionist/ism = breaking down a complex phenomenon into simpler components

  • Co-morbidity is hard to diagnose using the DSM, a system which relies on the user choosing the closest match from lists of symptoms and features
  • Splitting a mental disorder into symptoms & features is reductionist & studied as a whole may be more valid

Implicit Bias: Preconceived ideas
e.g. women can’t have schiz, more likely to have depression as they are emotional

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14
Q

FINISH What’s the strengths for reliability of diagnosis using DSM?

A
  • Brown et al. (2001) tested the reliability of the DSM-IV. They studied anxiety and mood disorders in 326 out-patients in Boston, USA. The patients underwent two independent clinical interviews and there was high level agreement for most of the DSM-IV categories.
  • high level of agreement between two psychologists in two separate interviews.
  • Wilson (1993) -> DSM-III developed to precisely tackle the unreliability of the previous manuals
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15
Q

What’s the weaknesses for reliability of diagnosis using DSM?

A
  • The reception to the new DSM-5 has been mixed. The British Psychological Society (BPS) published a largely critical response in which it attacked the whole concept of the DSM. It argued that the diagnosis should fit the patient, but the DSM-5 tries to make the patient fit the diagnosis
  • Andrews et al, 1999: There has been found to be only a 68% agreement between the ICD-10 and DSM-IV on an assessment of 1500 patients.
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16
Q

What’s the strengths for Reliability for ICD?

A

Jakobsen et al (2005)

  • Looked at in-patients with schizophrenia & out-patients with a history of psychosis (to look at reliability of the ICD-10 focus on schizophrenia)
    • 93% sensitivity & 87% predicted value to a diagnosis of schizophrenia & good agreement between ICD-10 & other diagnosis using another measure
    • Concluded: gave a reliable diagnosis of schizophrenia

Hiller et al (1992):

  • Compared DSM-III-R & ICD-10 - used both on same set of patients who were suffering from affective & psychotic disorders
    • ICD-10 gave higher reliability for all disorders except bipolar
    • Moderate agreement for schizophrenia (between DSM-III-R & ICD-10) but not for schizoaffective disorder (lack reliability)

Cheniaux et al (2009)

  • Aim: looked at reliability of diagnosis between DSM-IV & ICD-10
  • Concluded: Schizophrenia found more when ICD-10 was used than DSM-IV, Bipolar disorder most reliability diagnosed
  • ICD-10 is a reliable measure of schizophrenia & compares well with DSM-III-R (Hiller et al 1992) & (Jakobsen et al 2005)
  • Use of inter rater reliability - means more than one person uses the classification system/s with the same patients & when they come up with the same diagnosis - reliability - Also careful controls for the raters to work independently - avoid bias
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17
Q

What are the weaknesses for reliability of diagnosis using ICD?

A
  • Schizophrenia diagnosed more when ICD-10 used than DSM-IV used (Cheniaux et al 2009) - lack of reliability - could be due to the differences in duration (6 months = DSM, 1 month = ICD)
  • Schizoaffective disorder not reliably diagnosed (Cheniaux et al 2009) & (Hiller et al 1992) - lack of reliability of disorders relating to schizophrenia
  • Reliability figures around 0.50 agreement, lack of agreement to be considered
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18
Q

What’s the studies for Validity of ICD for schizophrenia?

A

Pihlajamaa et al (2008)
Validity of SZ diagnosis tested using DSM-III-R and the ICD-10. 807 SZ patients from Finland diagnosed with both books. Validity for DSM was 75% and ICD was 78%. The high level of agreement makes the diagnosis more reliable.

Jansson et al (2002)

- compared ICD-10 & DSM-IV
- Data gathered by interviews then compared to check validity of the diff classification systems
- Concluded: Diagnostic agreement between ICD-10 & DSM-IV (0.823)
- Generally diagnostic classification is valid but in depth there is differences - ------ - When the ICD-10 is used to diagnose schizophrenia the diagnosis matches a diagnosis using a different system, suggests ICD-10 is valid (Pihlajamaa et al 2008)
  • (Jansson et al 2002) ICD-10 & DSM-IV gave 80% agreement in diagnosis - high validity
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19
Q

What are the weakness for validity of diagnosis using ICD?

A
  • (Jansson et al 2002) different classification systems focused on different features & symptoms in schizophrenia (ICD-10 & ICD-9) - lack validity
    ICD-9 = ‘more conservative’
    ICD 10 = ‘more liberal’
  • Complexity of disorders:
  • schizophrenia spectrum disorder
  • schizoaffective disorder (both psychotic & mood disorders are present)
  • Bipolar disorder has symptoms of schizophrenia.
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20
Q

How do cultural issues affect diagnosis?

A
  • Symptoms of schizophrenia (hearing voices) in Western countries can be interpreted in different countries as possession of spirits, special & unique - positive view
  • Evrard (2014) - hearing voices is either a mental disorder or an individual difference/interpreted as an experience. Cultural Interpretation = DSM not always valid. Clinician from one culture must be aware of a patient from a diff culture to be influenced by their culture.
  • Malgady - costa rica - hearing voices is your ancestors talking to you
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21
Q

How do cultural issues not affect diagnosis?

A
  • Mental disorders (depression or schizophrenia) are clearly & scientifically defined with specific symptoms/features, that present the same all over the world - DSM not only used in America but also else where
  • Study: Lee (2006) used DSM-IV-TR in korea to see if it was valid and found valid
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22
Q

What is Schizophrenia?

A

Characterised by abnormalities; distortion of thoughts, perception & emotion & social withdrawal

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23
Q

What is Positive (Type 1) symptom?

A

Additions to behaviour (symptoms that can be seen & noted)

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24
Q

What is Negative (Type 2) symptom?

A

Lack of normal behaviour/functioning

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25
Q

What are examples of Positive Symptoms & what do they mean?

A
  • Hallucinations
    Seeing/Hearing/Smelling on something that’s not there
  • Delusions
    False beliefs that conflict with reality (thinking their movements are being controlled by someone)
  • Thought Insertion
    Individual thinks someone else is putting thoughts into their head
  • Disorganised Thinking
    Thoughts are not in logical order - doesn’t make sense
  • Catatonia
    Abnormality of movement & behaviour - not a lot of physical movement
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26
Q

What are examples of Negative Symptoms?

A
  • Diminished Emotional Expression
    Showing less emotion in non verbal communication (eye contact, facial expression)
  • Avolition
    Lack of motivation to complete usual, self motivated tasks (work)
27
Q

What are features of Schizophrenia?

A
  • Prevalence
    • 0.3-0.7% of developing schiz
    • Male: - Higher amount of negative symptoms. - Longer duration of disorder
    • Diagnosed during adolescence to mid 30s
    • Episodes develop gradually over time
  • Prognosis
    • 20% of diagnosed respond well to treatment
    • Large % remain ill with regular treatment
  • Other
    • Many patients show cognitive functioning deficits (working memory, language functioning & speed of info processing
    • Mood abnormalities are common - patients describe low moods as depressive episodes
    • Average life expectancy 10 or more years
28
Q

What’s the main neurotransmitter that is associated with schizophrenia/psychosis?

A

Dopamine

29
Q

What’s Amphetamine?

A

Drug which increases dopamine activity

30
Q

What’s a study on Amphetamine?

A

Randrup & Munkvad (1996):

Injecting amphetamines into rats to raise high dopamine levels - became aggressive + isolated. DOPAMINE LEVEL CHANGE = PSYCHOTIC BEHAVIOUR

[Evidence lead to the dopamine hypothesis.]

31
Q

What’s the Dopamine Hypothesis (who was it proposed by & what does it explain?

A
  • Who was it proposed by?
    Carlsson et al
  • What does it explain?
    Schizophrenia is caused by too much dopamine receptors
32
Q

What are the 2 ideas Dopamine Hypothesis focuses on?

A

Hypersensitivity of certain dopamine receptors (D2 receptors)
- Patients with the disorder are likely to “overreact” to the presence of neurotransmitter

Higher Density of dopamine receptors
- Higher density links to a higher chance of schizophrenia

33
Q

How are the dopamine pathways relevant to schizophrenia symptoms?

A

Mesolimbic Pathway
- (increase of dopamine in this pathway) contributes to POSITIVE SYMPTOMS

Mesocortical Pathway
- (increase of dopamine in this pathway) contributes to NEGATIVE SYMPTOMS

34
Q

What are the Strengths for the Dopamine Hypothesis?

A
- Antipsychotic drugs work by blocking dopamine receptors:
    Solomon Snyder (1985): Chlorpromazine = acts as an antagonist at dopamine receptors (D1 & D2)
  • Amphetamine - treatment of rats; Randrup & Munkvad (1996):
    Injected rats with Amphetamine, displayed psychotic symptoms of aggression & isolation
  • Parkinson’s disease - L-Dopa:
    People with Parkinson’s disease (with low lvl of dopamine in the brain) given L-Dopa (to increase dopamine) and show psychotic symptoms (Type 1)
35
Q

What are the Weaknesses for the Dopamine Hypothesis?

A
  • Not all schizophrenic people respond to typical antipsychotic medication
    Alpert & Friedhoff (1980) →some patients don’t show any improvement after taking dopamine antagonists
  • Modern antipsychotic drug - Clozapine
    • Block serotonin receptors
    • Increase dopamine levels - contradicting the dopamine hypothesis
  • Second-generation Immigrants - can’t explain why certain groups are more likely to have schizophrenia
    Wim Veling → Moroccan immigrants more likely to have schizophrenia than Turkish immigrants - environmental factors; social stress/discrimination → more prone to psychosis
36
Q

What’s the Glutamate hypothesis (who was it proposed by & what does it explain & how is this supported by angel dust)?

A
  • Proposed by?
    Carlsson et al. (1999/2000)
  • Explanation?
    There is more to the neurotransmitter explanation than excess dopamine
  • How is this supported by PCP (angel dust)?
    NMDA = glutamate receptor, activated when glutamate binds to it
    • Angel dust produce psychotic symptoms but doesn’t activate dopamine, activates glutamate receptors (NMDA)
    • Release of dopamine is increased, by decreasing glutamate (blocking NMDA receptors which glutamate binds with)
37
Q

What are the Strengths for the Glutamate Hypothesis?

A

Glutamate Hypothesis = Dopamine Hypothesis

- Both hypothesis work together & expand on it rather than replacing it
- Evidence from the dopamine hypothesis can be incorporated into the glutamate hypothesis
- More knowledge to be built together - adding to its scientific credibility

Evidence from Neuroimaging & Animal studies

- To show that blocking glutamate relates to psychotic symptoms (negative affect in schizophrenia)
- Findings of the studies tend to support one another - suggests they're reliable
38
Q

What are the Weaknesses for the Glutamate Hypothesis?

A

Animal studies - Lack validity
- Erratic behaviour/psychotic symptoms might not relate to psychotic behaviour in humans

PET scanning
- Carlsson et al (1999) → when scanning humans might feel under pressure (responding differently than normal) - findings lack validity (esp on brain activity)

39
Q

What evidence is there for the link between disorder and genetics?

A

Evidence of a strong heritable factor in the development of the disorder

40
Q

What’s the general population chance of getting schizophrenia?

A

less than 1%

41
Q

What’s the difference between MZ twins & DZ twins in schizophrenia?

A
  • Identical twins (MZ) are more likely to both have schizophrenia than non-identical twins (DZ)
  • e.g. Gottesman (1991) 48% chance of schizophrenia in MZ twins whilst DZ twins is 17%
42
Q

What’s the overall explanation of the biological theory on schiz?

A

Higher genetic relatedness = Higher risk of Schizophrenia

43
Q

What’s the Gottesman and Shields study (1966)?

A

Aim?
- How far schizophrenia was genetic & replicate other studies that found a genetic link in schizophrenia

Procedure?

- 62 schizophrenic patients - half male & half female - aged 19-64 - all had been at a hospital
- Used blood & visual tests to check whether the twins were MZ & DZ - 24 MZ identified & 33 DZ twins identified
- Gottesman looked at the concordance rate within MZ & DZ twins to see what % of cases when one was diagnosed with schizophrenia, the other one was too.
- MZ twins had a higher concordance rate
- DZ twins had a lower concordance rate

Results?
- Concordance rate for MZ twins for schiz: 54% and DZ is 18%

44
Q

What’s the strengths for the Gottesman and Shields study (1966)?

A

Replicates other studies
- Replicates Inouye (1961) - found 74% concordance rate with progressive chronic schiz & 39% with mild transient schiz - reliable

Care when measuring both the twin situation & diagnosis

- Addresses criticisms of previous studies by detailing the sample carefully so that it was understood which twins were included & why
- Great detail on the diagnosis - schiz, other psychosis, some abnormality
45
Q

What’s the weaknesses for the Gottesman and Shields study (1966)?

A

Concordance rate - scale

- Only notes whether if one twin has some abnormality, the other has it too
- Been useful to have info about the degree of the abnormality, e.g. scale showing "schiz" through "other psychiatric diagnosis", to "some abnormality" to "normal"

Different forms of schiz

- Suggests that some of the disorders diagnosed might come from life experiences (prisoner from war) rather than genes
- Study did not distinguish between reasons for schiz
46
Q

What are the strengths for genetic explanation for schizophrenia?

A

Adoption studies - Tienari (2002)

- Account for environmental factors
- E.g. Tienari (2002) found 7% of adoptees with schiz had biological mothers with schiz

Family studies & Twin studies - multiple methods

- Family studies can help identify gene issues, e.g. deletion, which shows symptoms of psychosis
- Twin studies shows that genes explain schizophrenia - DNA pooling used to compare DNA with those that have schizophrenia against controls to look for gene variants
- Many methods help if there's the same findings - reliability
47
Q

What are the weaknesses for genetic explanation for schizophrenia?

A

Complex

- Complexity in variants - variations exist within individuals rather than seeing it in patterns of families - are sub microscopic
- e.g. Harrison & Owen (2003) - 6 different genes involved in developing the disorder

Family studies

- Does not recognise that findings of schiz could be due to environmental factors
- E.g. Schiz may be a result of stress caused by negative emotions of families
48
Q

What’s the Cognitive explanation for schiz?

A
  • Attributing Type 1 symptoms of schiz to biological causes
  • e.g. Hallucinations + delusions - associated with bio factors due to increased dopamine levels BUT when they try to understand the experience, they begin to show other symptoms of the illness
49
Q

What’s evidence for the Cognitive theory for schiz?

A

Frith (1979)

- Schizophrenic patients have increased self awareness
- Can't filter out unnecessary cognitive noise from internal info processing
50
Q

What’s the strengths of Cognitive theory for schiz?

A

Gold and Harvey (1993)

- Ppl with schiz score lower on attention, memory, problem solving tests
- Shows cognitive deficits

McGuire et al (1966)

- During hallucinations there's reduced activity in temporal lobe (monitors inner speech)
- Thus experiencing an internal conversation, but were more likely to perceive the voice belonging to someone else

[Support Frith’s explanation of schiz patients unable to distinguish their thoughts]

51
Q

What’s the weaknesses of Cognitive theory or schiz?

A

Beck et al (2009)
- Reduced dopamine levels causes brain to struggle with info processing

Sitskoom et al (2004)

- Cognitive deficits found in patients with schiz was also found in their relatives who do not have the disorder
- May be a genetic component causing the cognitive deficit
52
Q

What’s the Social Causation hypothesis?

A

Environmental factors have a massive impact on schizophrenia or contribute to it

53
Q

What are the specific aspects for Social Causation?

A

Social Adversity
- Basic needs such as nutrition, warmth, shelter, intellectual, emotional & social needs are not met by an individual

Social Class

- Social class shows someone's position in society = stress levels related to position in society
- Lower social classes have a higher chance of getting schizophrenia or involved in its development

Immigrant & Minority Status

- Tends to be disadvantaged in educational factors, social class, housing + discrimination
- Boydell et al (2001) →first & second generation immigrants are at greater risk of schiz than the general population

Social Isolation

- An individual becomes isolated from social situations
- Robert Faris (1934) → ppl with schiz withdraw because they feel that contact with others is stressful. Isolation cuts the individual off from feedback about what behaviours are inappropriate, they begin behaving strangely

Urbanicity

- The impact living in an urban environment has on an individual
- William Eaton (1974) → City life is more stressful than rural life & long exposure to stress causes schizophrenia
54
Q

What are the strengths for Social Causation hypothesis?

A

Significant correlation between urban dwelling & schizophrenia

- Evangelos Vassos et al (2012) → Correlated location (urban to rural) with schiz risk & found a link
- Found a link - risk was 2.37 times higher for ppl living in urban areas

Ethnic Identity
- Veiling et al (2010) → ppl classed as marginalised (weak national & ethnic identity) were at greater risk of schiz than ppl classed as strong national & ethnic identity)

55
Q

What are the weaknesses for Social Causation hypothesis?

A

Not a complete explanation of schizophrenia

- There is genetic contribution to schiz
- Suggests environmental factors may only trigger schiz in ppl who genetically already have it

Social factors

- Not having social support, instability in community, leading to social isolation.
- Social factors can help explain schiz but its hard to know which social factors are involved as social factors interact & hard to isolate for study.
56
Q

What are the 2 type of antipsychotic drugs?

A

Atypical

- Newer drugs, better and more effective
- Reduce some negative symptoms (as well as positive symptoms) which typical doesn't
- E.g. Clozapine

Typical

- Well established, old, established in 1950s
- lots of unpleasant side effects
- Does not work negative symptoms
- E.g. Chlorpromazine
57
Q

What are the side effects associated with antipsychotic drugs?

A
  • Sleepiness & Tiredness
  • Shaking & Muscle spasms
  • Low blood pressure
  • Problem with sex drive
  • Weight gain
58
Q

How do antipsychotic drugs work?

A
  • Reduce the level of dopamine in areas associated with psychotic symptoms
  • Block D2 receptors which prevents dopamine binding
  • Depolarising the neuron
59
Q

What’s a study from Meltzer et al (2004)? [Bio treatment for schiz]

A

Aim?
- Looked at the effectiveness of drug treatment?

Procedure?

- Used 481 patients with schizophrenia & randomly assigned into groups
- Groups given a placebo (pill looked like an antipsychotic but had no effect), typical antipsychotic; haloperidol or investigational drugs (4 new drugs)

Results?

- Haloperidol & 2 of the new drugs had reduced symptoms
- Placebo & the 2 of the other new drugs were still the same

[There are atypical antipsychotic drugs that are successful]

60
Q

What’s a study from Guo et al (2011)? [Bio treatment for schiz]

A

Aim?
- Look at 7 antipsychotic drugs used in the early stages of schizophrenia to establish their effectiveness & safety

Procedure?

- Involved with 1,133 people with schizophrenia
- 7 drugs were used - Individuals were only taking one of the drugs
- Measured the rate of discontinuing the treatment & clinical outcomes

Results?

- Similar % for all 7 drugs that stop taking the drugs - quetiapine being the largest & clozapine being the lowest
- Chlorpromazine & sulpiride shows more extrapyramidal symptoms
- Weight gain was more common in clozapine & olanzapine

[Concluded: no drug was more effective than another]

61
Q

What’s a study from Hartling et al (2012)? [Bio treatment for schiz]

A

Aim?
- Looked at first & second generation medications for schiz

Procedure?

- Looked at studies using randomised trials
- lasted for 2 years

Results?

- Haloperidol improved more positive symptoms than olanzapine, though olanzapine improved negative symptoms compared to haloperidol
- Evidence of a higher risk of tardive dyskinesia for chlorpromazine as against clozapine → reflects Guo et al (2011): chlorpromazine showed more extrapyramidal symptoms
62
Q

What are the strengths for drug therapy for schizophrenia?

A

Pre-1950’s treatments for schiz

- Drugs are better compared to treatments for schiz before 1950s - more ethical & effective
- E.g. Insulin shock therapy

Rests on biological evidence

- Rests on biological evidence about the causes of schiz so is supported by theory, helps considering the effectiveness
- e.g. antipsychotic drugs target dopamine at the synapse - Carlsson et al (2000)

Effectiveness of drug
- clozapine is effective (improve delusions & hallucinations) even though it can have serious side effects (lower white blood cells count)

63
Q

What are the weaknesses for drug therapy for schizophrenia?

A

Discontinuing medication

- Schizophrenic patients often don't continue taking the drugs that's prescribed
- Guo et al. → over 30%
- WHY? schizophrenic ppls might forget to take it regularly or side effects are too uncomfortable

Ethical
- Drugs described as “chemical strait jacket” & some think it the control by society is unacceptable

Side effects

- Side effects are unpleasant & the side effects itself can require medication
- Typical drugs → tardive dyskinesia
- Atypical drugs → weight gain
- E.g. Clozapine  (atypical) - people closely monitored with blood tests every 2 weeks to check their white blood cells (because white blood cells are lowered)