Topic 4 - Epigenetics

Question 1

Heterochromatin?

Answer 1

Dark stained

Question 2

Euchromatin?

Answer 2

Light stained

Question 3

What is paramutation?

Answer 3

Result of an interaction between specific alleles of a gene in het state which results in heritable change in expression of one allele

Question 4

Which allele is being altered?

Answer 4

Paramutable allele

Question 5

Which allele is altering?

Answer 5

Paramutagenic allele

Question 6

Which para creates more RNA?

Answer 6

Paramutable

Question 7

What is mop1?

Answer 7

Mediator of permutation, gene that is required for transcriptional silencing

Question 8

How does mop 1 create paramutation?

Answer 8

Transfers methylation state of paramutagenic allele to the paramutable allele

Question 9

What happens when genome methylation is state messed up?

Answer 9

Affects phenotype in a bad way

Question 10

Open vs. Condensed chromatin?

Answer 10

Opens permits expression
Condensed inhibits expression

Question 11

What happens when DNase is applied to chromatin?

Answer 11

Open - sensitive to dnAse
Closed - not sensitive to dnAse

Question 12

Where is open chromatin on the genome?

Answer 12

Open on ends
closed in middle

Question 13

Does recombination happen at closedor open chromatin?

Answer 13

Open

Question 14

Where does op en chromatin occur on a mutant mop 1 vs. A normal mop1

Answer 14

Open chromatin on middle of chromosome if a mutant