Topic 3: Awareness And Confabulation Flashcards

1
Q

research has predominantly approached confabulation as …

A

A useful neurocognitive symptom from which one can infer cognitive models of normal memory function

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2
Q

Confabulation is frequently associated with lesions to the …

A

Ventromedial prefrontal cortex
As well as other surrounding areas, including the orbifrontal cortex, the basal forebrain, the anterior cingulated cortex, and other ‘anterior limbic’ areas.

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3
Q

Which impairments are necessary for confabulations to occur?

A

Most studies seem to suggest that although impaired memory may be necessary for confabulation to occur, it is not sufficient to cause it. Most investigations suggest that some degree of executive function impairment seems also to be necessary for confabulation to occur

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4
Q

Two main classes of theories regarding confabulations have been put forward, which ones?

A
  • explanations that focus on impaired temporality or reality monitoring
  • explanations that emphasize deficits in the control of memory retrieval
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5
Q

What observation led to the suggestion that confabulating patients have a disturbed ability to determine chronology?

A

Confabulating often misattribute experiences of a given time to events that occurred at another time, or confuse the order of experienced events.

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6
Q

How is self-monitoring training used in the treatment of confabulations?

A

Patients have to self report their confabulations using a hand-held clicker

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7
Q

What may influence the way that confabulating people react to rehabilitation?

A

The patients subjective experience of themselves following brain damage. The role of patients own experiences on their post morbid self may influence functional outcome and psychosocial well-being in traumatic brain injury

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8
Q

What kind of errors are amnestic errors? And confabulating errors?

A

Amnesic errors are errors of omission and confabulating errors are errors of commission

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9
Q

Disorders of self-awareness can range from mild to severe, name three stages.

A
  • anosognosia
  • impaired self awareness
  • denial
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10
Q

What is anosognosia?

A

Complete unawareness of a lost neurological or neuropsychological function

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11
Q

What is impaired self awareness (ISA)?

A

Partial syndrome of unawareness of the disturbed function
Patients with ISA show some awareness of their impairments
They may use both defensive and non-defensive approaches for coping with their limited awareness of an impaired function

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12
Q

What is denial?

A

A psychological method of coping with a loss or threat of loss that has personal significance to the individual

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13
Q

What supports the clinican’s rating scale?

A

The separation of ISA and Denial of Disability (DD)

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14
Q

What is characteristic for patients with ISA, and for patients with DD?

A

Patients with ISA are often perplexed when given feedback about their impairments, no negative or positive reaction.

Patients with DD often become irritated when given feedback, they often disregard the feedback

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15
Q

What is the main difference between anosognosia and denial?

A

Unlike denial, anosognosia results from brain damage

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16
Q

What is evidence for the statement that an inability to cope with emotional consequences of a severe neurological loss is not sufficient?

A

Greater frequency of anosognosia after cerebral than peripheral paralysis suggests that an inability to cope with emotional consequences of a severe neurological loss is not sufficient since many peripheral disorders are very impairing but practically never associated with anosognosia.

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17
Q

Does patients with anosognosia have implicit knowledge?

A

Yes, there is an inconsistency between patients verbal answers and behaviors.
Example: patients deny paralysis but accept to stay in bed or in a wheelchair

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18
Q

What phenomena are associated with anosognosia ?

A
  • neglect
  • somatoparaphrenia
  • misoplegia
  • anosodiaphoria
  • confabulation
  • alexithymia
19
Q

What is neglect?

A

Failure to report, respond or attend to stimuli on the opposite side of space to the lesion. Impairment is not caused by simple sensory or motor deficits

20
Q

What is somatoparaphrenia?

A

The delusional belief whereby a patient feels that a part of one’s body does not belong to his or her body, such as a paralyzed limb.
Is typically associated with neglect. Often in anosognosia for hemiplegia.

21
Q

What is misoplegia ?

A

Morbid dislike of hatred of paralyzed limbs in patients with hemiplegia

22
Q

What is anosodiaphoria?

A

A condition in which injured patients seem indifferent to the existence of their handicap

23
Q

What is the difference between confabulation and lying?

A

Confabulations are not made to deceive and because individuals are unaware that their information is incorrect

24
Q

What is alexithymia?

A

An alteration in emotional processing characterized by:

  • difficulty in identifying emotions and differentiating them from other physical states.
  • difficulty in describing emotions
  • limited ability to fantasize scenarios with significant emotional content
  • concrete cognitive style that disregards the complex emotional, motivational and symbolic aspects of human behavior
25
Q

What is the prognosis for disorders of awareness?

A

Impairments of awareness show different courses, spontaneous improvement with time can occur in some patients (mostly following stroke). Some patients may benefit from rehabilitation exercises.

26
Q

Why are disorders of awareness of clinical relevance?

A

Because presence of anosognosia and ISA negatively influences the process and outcome of neuro rehabilitation. Disorders of self awareness affect the patients desire/motivation to follow treatment instructions or hamper rehabilitation. Also, they cause considerable frustration to relatives who try to provide assistance.

27
Q

What are the causes of anosognosia?

A

Causes may vary, depending on the nature of the underlying brain dysfunction and the different neurological and neuropsychological deficits for which the patient is not aware.

28
Q

Where do we find lesions in case of anosognosia ?

A

Frequent involvement of right hemisphere (in particular of frontal and parietal-temporal areas). However, no specific lesion location necessary to cause anosognosia

29
Q

Anosognosia is often modality specific; a patient may be unaware of a hemiparesis but recognize his memory impairment. What are theoretical implications of this observation?

A
  • is awareness of different neurological and neuropsychological functions modularly organized?
  • is awareness of a given function represented in the highest organization of that functional capacity?
30
Q

Which neuropsychological functions have been discussed in the context of anosognosia?

A
  • episodic memory

- executive functions

31
Q

Name the models of anosognosia

A
  • conscious awareness system (CAS)
  • pyramidal model
  • a new cognitive model
32
Q

What is the conscious awareness system (CAS)?

A

A system located in the medial and lateral parietal regions, it receivers input about the state of individual functional modules and passes the information on to an executive (frontal) system.

33
Q

How can CAS explain anosognosia for specific deficits? And how can more generalized anosognosia be explained by CAS?

A
  • anosognosia for specific deficits: disconnection of the CAS from individual modules
  • more generalized anosognosia : damage to the CAS or the executive system
34
Q

What is the pyramidal model?

A

Possible levels of impairment of awareness with different behavioral implications
A. Intellectual awareness
B. Emergent awareness
c. Anticipatory awareness

35
Q

What is the new cognitive model by Rosen?

A

A working model that identifies specific functions that may be important for awareness of changes in one’s abilities.

  • performance abilities
  • emotional processing
  • memory
36
Q

Anosognosia is often modality specific, what is the consequence of this finding for assessment?

A

Assessment of awareness requires consideration of several functional domains levels of awareness are usually determined on the basis of discrepancies between the patients assessment of his abilities and assessment of caregivers/clinican’s/and objective measures.

37
Q

What is the patient competency rating scale?

A

This scale assesses discrepancies between patients and caregivers in judgements relating to activities of daily living, cognition, interpersonal relationships and emotion. Scores from caregivers are subtracted from patient scores

38
Q

What is he self-awareness of deficit interview?

A

A semi-structured interview for clinican’s investigating three major domains: self-awareness of deficit, self-awareness of functional implications of the deficits and the ability to set realistic goals.

39
Q

Why is neuropsychological testing of the patients self-awareness attractive?

A

Because it is objective and does not require a separate informant

40
Q

Why are neuropsychological tests not the ideal metric to measure patients awareness of their abilities in real life?

A

Because neuropsychological tests are designed to address specific cognitive domains rather than functional abilities.

41
Q

What are prediction discrepancy models?

A

In prediction discrepancy models, specific neuropsychological tests are explained to patients and patients are asked to predict how they would perform on such tests. Discrepancies between patients predictions and actual performance are taken as measures of patient awareness

42
Q

What are postdiction discrepancy models?

A

Patients have to perform neuropsychological tests. After completion, patients are asked to rate how well they have performed. Discrepancies between their judgements and performances are calculated.

43
Q

What are confabulations?

A

False memories without being aware of their falsehood