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Pharm Final > Topic 20 Glucocort Immunosuppre > Flashcards

Topic 20 Glucocort Immunosuppre Flashcards

1
Q

*All glucocorticoids are what?

A

immunosuppressive even as a single dose!

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2
Q

glucocorticoids are what kind of steroid?

A

catabolic steroids

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3
Q

glucocorticoids cause “feedback inhibition” of what?

A

glucocorticoid and thyroid -stimulating hormone production

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4
Q

Glucocorticoid Side Effects (6)

A
  • Bone density loss
  • Myopathy
  • ”Steroid rage” and personality changes
  • Gastric ulcers
  • Diabetogenic
  • ”Moon Face & Humpback”
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5
Q

Glucocorticoid risks for me/perfusion on pump

A

increase risk of infection, high blood pressure

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6
Q

Addisons disease

A

when adrenal gland not produce sufficient steroid hormones (glucocorticoids and often mineralocorticoids).

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7
Q

Cushing Disease

A

adrenal gland over working, increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism)

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8
Q

-Hydrocortisone

A

Solu-Cortef

Glucocorticoid Drugs

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9
Q

-Dexamethasone

A

Decadron

Glucocorticoid Drugs

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10
Q

-Methylprednisolone

A

Medrol

Glucocorticoid Drugs

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11
Q

Glucocorticoid Drugs (5)

A
  • Hydrocortisone (Solu-Cortef)
  • Dexamethasone (Decadron)
  • Prednisolone
  • Prednisone
  • Methylprednisolone (Medrol)
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12
Q

D.O.C.s for moderate rejection episodes

A

Glucocorticoids

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13
Q

Glucocorticoids have the *Most side-effects of any immunosuppressive category when given how?

A

at high doses over the long term?

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14
Q

-Cyclosporin

A

Sandimmune

Calcineurin Inhibitors

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15
Q

Tacrolimus

A

Prograf

Calcineurin Inhibitors
Orders of magnitude more potent than Cycylosporins.
•More nephrotoxic/less cardiotoxic than Cyclosporins.

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16
Q

Calcineurin Inhibitors Drugs (2)

A
  • Cyclosporin (Sandimmune)

- Tacrolimus (Prograf)

17
Q

mTOR Inhibitors

A

Sirolimus (Rapamune)

18
Q

Sirolimus

A

Rapamune

mTOR Inhibitor

19
Q

Antiproliferative Agents (3)

A
  • Azathioprine (Imuran)
  • Mycophenolate Mofetil (Cellcept)
  • Mycophenolatesodium (Myfortic)
20
Q

Azathioprine

A

Imuran

Antiproliferative Agents
best on acute rather than chronic immunogenic response

21
Q

Mycophenolate Mofetil

A

Cellcept

Antiproliferative Agents
Mainly GI and bone-marrow suppression

22
Q

Mycophenolate sodium

A

Myfortic

Antiproliferative Agents
“slower-releasing” and “enterically-pleasing” form of Mycophenolate Mofetil

23
Q

*Monoclonal antibodies contain ONLY what type of antibody ???

A

one type of antibody that is derived from a

single cloned B-lymphocyte

24
Q

Dose-dependent nephrotoxicity, immune suppression (duh!), hepatotoxicity, cardiotoxicity, and many others

A

Cyclosporin

Calcineurin Inhibitors

25
Q

The “break-through” drug that allowed transplants to successfully occur

A

Cyclosporin

Calcineurin Inhibitors

26
Q

The major T-cell activator

A

Calcineurin

Pharm Final (6 decks)

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