Topic 11: meiosis Flashcards
Compare sexual/asexual reproduction
ASEXUAL:
- Single individual passes genes > offspring = without fusion of gametes
- Offspring are genetically identical clones of parents
SEXUAL:
- 2 parent to create offspring = combination of genes inherited from both parents
What is the role of meiosis in sexual reproduction?
- Reproduction is via fertilization of gametes
- Gametes produced by meiosis
- Fertilized egg = zygote
- Zygote produces somatic cells via mitosis
Define meiosis
- Cell division producing gametes
- Reduction of chromosomes half = n = 23
- Produces haploids from diploids
- After fertilization = 2n
- Produces haploids from diploids
- 2 sets of cell division
- 4 daughter cells
Define karyotype
- Ordered display of pairs of chromosomes in a cell
- Each somatic cell = 44 autosomes = 22 pairs
- 2 sex chromosomes XX/XY = 46 in total
Define autosomes
- Chromosomes that don’t determine sex
Define homologous chromosomes
- 2 chromosomes in each pair during meiosis
- 1 paternal 1 maternal
- Same length + shape + carry genes controlling the same inherited characteristic
- Same gene = different alleles
Define gene locus
- Location of a particular gene on a chromosome
Describe the difference between animal sexual life cycle + other organisms
ANIMAL:
- Gametes = only haploid cells + only produced via meiosis + don’t undergo further division
- Only diploid cells divide by mitosis
PLANTS/FUNGI/PROTISTS
- Both haploid /diploid cells divide by mitosis
Describe the difference between meiosis I + meiosis II
- Meiosis I = separates homologous chromosomes = 2 haploid replicated chromosomes
- Meiosis II = separate sister chromoatids = 4 haploids unreplicated
Describe meiosis I
- Interphase =chromosomes duplicate = sister chromatids + centrosomes duplicate
- 4 phases:
> Prophase I
> Metaphase I
> Anaphase I
> Telophase I/cytokinesis
Describe prophase I
- 90% time of meiosis
- Chromosomes start to condense
- Synapsis = pairing homologous chromosomes = each pair forms tetrad = synaptonemal complex
- Genetic recombination = crossing over = exchange of DNA segments between non-sister chromatids in the homologous chromosomes
Describe metaphase I
- Tetrads line up at metaphase plate
- Microtubules from poles attached > kinetochore of each chromosome in tetrad
Describe anaphase I
- Homologous pair separate = move to opposite poles
- Sister chromatids = stay attached at centromere
Describe telophase I + cytokinesis
TELOPHASE:
- Each half of cell has haploid set = 2 sister chromatids
- Cleavage furrow forms = division = 2 haploid daughter cells
Describe meiosis II
- Similar to mitosis
- 4 phases also:
> Prophase II
> Metaphase II
> Anaphase II
> Telophase II + cytokinesis
Describe prophase II
- Spindle apparatus forms
- Chromosomes move towards metaphase plates
Describe metaphase II
- Sister chromatids arranged at metaphase plate
- If crossing over occurred in meiosis I = sister chromatids may not be genetically identical
- Microtubules attach to kinetochores
Describe anaphase II
- Sister chromatids move towards opposite poles = separate
Describe telophase II + cytokinesis
TELOPHASE
- Nuclei reforms + chromosomes decondense
CYTOKINESIS
- Division of cytoplasm
- 4 daughter cells = genetically distinct
3 unique events in meiosis
1) Synapsis + crossing over
2) Metaphase I = alignment of homologous chromosome pairs instead of individual
3) Anaphase I = separation of homologous chromosomes instead of sister chromatids
Compare/contrast mitosis/meiosis
DNA REPLICATION
- Mitosis + meiosis = occurs in interphase before it begins
NUMBER OF DIVISIONS
- Mitosis = 1 including all phases
- Meiosis = 2 all phases done twice
SYNAPSIS OF HOMOLOGOUS CHROMOSOMES
- Meiosis = during prophase I
NUMBER OF DAUGHTER CELLS
- Mitosis = 2 diploids = 2n = genetically identical
- Meiosis = 4 haploids = n = genetically variability
4 factors causing genetic variation
1) Crossing over = genetic recombination
2) Independent assortment of chromosomes = 2^23 combinations of homologous chromosomes = 8 million gametes
3) Random fertilization = 64 trillion possible offspring
4) Mutations = create different versions of genes
Describe independent assortment
- Homologous pairs align randomly in metaphase I
Explain the evolutionary significance of genetic variation
- Sexual reproduction = genetic variation = via mutations
- Natural selection = genetic variation that’s favored