Topic 10- Cancer Genetics Flashcards
1
Q
Definition of Oncogenes
A
Mutant form of proto-oncogene
sufficient to promote cell division
2
Q
What Oncogenes does
A
Gain-of-function or dominant mutation
3
Q
Definition of RAS gene
A
stimulate cell division functions
4
Q
What RAS gene does
A
flips back & forth between:
Active = bound to GTP
Inactive = bound to GDP
5
Q
Definition of Proto-oncogene
A
normal genes which
promote
cell division
6
Q
What Proto-oncogene does
A
protein kinases, growth factors, transcription factors, etc.
7
Q
Definition of Oncoviruses
A
A virus that can cause cancer
8
Q
What Oncoviruses do
A
Virus infects cell & takes over cellular machinery in order to replicate itself
