Top 300 Drugs Part B Flashcards
To prepare the student in the mastery of the top 300 drugs for the preparation of the NAPLEX
What is the brand name of of epinephrine used during Anaphylaxis?
Epipen 2-PAK
What is the indication for Epipen 2-PAK
Anaphylaxis
What are the primary adverse effects of Epipen 2-PAK?
Anxiety, restlessness, tremor, sweating, palpitations, nausea, vomiting, hypertension, tachycardia Warnings: inject into thigh only, not IV, use cautiously in CV disease
What is the brand name of Dabigatran?
Pradaxa
What is the indication for Pradaxa?
Anticoagulation
What is the Black Box Warning for Pradaxa?
Discontinuing dabigatran places patients at an increased risk of thrombotic events. If dabigatran must be discontinued for a reason other than pathological bleeding, consider the use of another anticoagulant during the time of interruption.
What are the contraindications/warnings for Dabigatran?
Active pathological bleed and patients with mechanical prosethetic heart valve(s)/
What is the primary adverse effect of Dabigatran?
Bleeding
What are the brand name of warfarin SOD?
Coumadin, Jantoven
What is the indication for Jantoven?
Anticoagulation
What is the Black Box Warning for Coumadin?
Bleeding
What are the contraindications/warnings associated with Jantoven?
Hemorrhagic tendencies, blood dyscrasias,
pregnancy, uncontrolled hypertension, non-compliant patient, bacterial endocarditis, eclampsia, pericarditis
What is the primary adverse effect of warfarin SOD?
Bleeding
What are the brand name of amiodarone HCL?
Cordarone, Pacerone
What is the indication for Amiodarone HCL?
Arrhythmias
What are the Black Box Warnings Associated with Pacerone/Cordarone?
Liver Toxicity, QT prolongation, pulmonary toxicity, initiation should be done in the hospital
What are the contraindications/warnings associated with Pacerone/Cordarone?
“Severe sinus-node dysfunction, 2nd/3rd degree heart block (unless patient has a functional artificial pacemaker), bradycardia causing syncope, cardiogenic shock”
What are the brand names associated with Beclomethasone
Qvar, Qnasl
What are the indications for Qvar and Qnasl?
Asthma/allergic Rhinitis
What are the Contraindications/warnings Qvar and Qnasl?
Acute asthma
What are the primary adverse effects associated with Qvar and Qnasl?
URI, throat irritation, sinusitis, oral candidiasis, headache
What are the brand names for Fluticasone?
Flovent HFA, Flonase
What are the indications for fluticasone?
Asthma/allergic rhinitis
What are the contraindications/warnings associated with Flovent HFA/ Flonase?
Status asthmaticus
What are the primary adverse effects associated with Flovent HFA/ Flonase?
URI, throat irritation, sinusitis, oral candidiasis, headache
What is the brand name for Montelukast SOD?
Singulair
What are the indications for Singulair?
Asthmas/ allergic rhinitis
What are the contraindications/warnings associated with Singulair?
Active liver disease- zileuton
What re the primary adverse effects of Singulair?
Headache, dyspepsia
What is the brand name for Budesonide?
Pulmicort
What are the indications for Budesonide?
Asthma/allergic rhinitis/crohn’s disease
What are the contraindications/warnings associated with Budesonide?
Not for relief of acute bronchospasm
What are the primary side effects of Budesonide?
Headache, URI, diarrhea, side effects common to short or long-term corticosteriods
What is the brand name to Salmeterol + Fluticasone (LABA + Corticosteroid)?
Advair diskus
What are the indications for ADVAIR?
Asthma/COPD
What are the contraindications/warnings associated with Advair?
Status asthmaticus, acute COPD exacerbation, severe allergy to milk proteins.
What are the primary adverse effects of Advair?
URTIs, pharyngitis, hoarseness/dysphonia, cough, headache Warnings: LABA increased risk of death, deterioration of disease, oral candiasis, pneumonia, immunosuppression, adrenal suppression, growth effects, glaucoma/cataracts
What are the brand names to albuterol HFA (SABA)?
VENTOLIN HFA PROAIR HFA PROVENTIL HFA
What are the indications for albuterol HFA (SABA)?
Asthma/COPD
What are the primary side effects of albuterol?
Tremor, nausea, tachycardia, palpitations, nervousness, increased BP Warnings: paradoxical bronchospasm, cardiovascular events, asthma deterioration
What is the brand name for tiotropium?
Spiriva
What is the indications for Spiriva?
Asthma/COPD
What are the primary side effects of Spiriva?
Dry mouth, abdominal pain, URTIs, chest pain Warnings: paradoxical bronchospasm, narrow-angle glaucoma, urinary retention
What are the brand names for bupropion HCL XL or SR (antidepressant)
Wellbutrin XL, Zyban
What are the indications for bupropion HCL XL or SR?
Depression/smoking cessation
What are the black box warnings of bupropion XL or SR?
Suicidal ideation in children and young adults, neuropsychiatric effects when used for smoking cessation
What are the contraindications/warnings of bupropion XL or SR?
Use of MAOIs, methylene blue, linezolid; bullemia, anorexia, abrupt discontinuation of sedatives or ethanol
What are the primary side effects of bupropion XL or SR?
headache, insomnia, tremor, nausea, constipation
What is the brand name to varenicline (nicotinic receptor partial agonist)?
Chantix
What is the indication for varenicline?
Smoking cessation
What is the black box warning associated with varenicline?
Serious neuropsychiatric events (depression, suicide) - weigh risk versus benefits of smoking cessation
What are the primary side effects of varenicline?
N, constipation, abnormal dreams, headache, insomnia, abnormal behavior including suicide, angina, MI
What is the brand name of Niacin ER (nicotinic Acid)
Niaspan
What is the indication for niacin ER?
Dyslipidemia
What are contraindications/warnings of niacin ER?
“Active Liver Disease (including any unexplained elevations
in hepatic transaminases), pregnancy, breast-feeding,
taking concurrent strong 3A4 inhibitors”
What are the primary side effects of niacin ER?
Flushing, itching, nausea, vomiting, hepatotoxicity, BG increase, gout
What is the brand name for atorvastatin CA (HMG-CoA Reductase Inhibitor)
Lipitor
What is the indication for atorvastatin?
dyslipidemia
What are the contraindications/warnings associated with atorvastatin?
“Active Liver Disease (including any unexplained elevations
in hepatic transaminases), pregnancy, breast-feeding,
taking concurrent strong 3A4 inhibitors”
What are the primary side effects associated with Lipitor?
Arthalgias, myalgias, diarrhea, LFT increase, rhabdomyolysis, tendon rupture
What is the brand name for exetimibe (Cholesterol absorption inhibitor)
Zetia
What is the indication for Ezetimibe?
Dyslipidemia
What are the contraindications/warnings of Ezetimibe?
Pregnancy, breast feeding, use in combo with statins if severe liver disease
What are the primary side effects of Zetia?
URI, diarrhea, arthralgia
What is the brand name of ezetimibe/simvastatin (Cholesterol Absorption Inhibitor + HMG-CoA Reductase Inhibitor)
Vytorin
What is the indication for Vytorin
Dyslipidemia
What are the warnings/precautions of Vytorin?
“Active Liver Disease (including any unexplained elevations
in hepatic transaminases), pregnancy, breast-feeding,
taking concurrent strong 3A4 inhibitors”
What is the brand name of fenofibrate (fibric acid)?
Tricor
What is the indication for Tricor?
Dyslipidemia
What are the contraindications/warnings associated with fenofibrate?
Gallbladder disease, breast feeding, severe renal impairment, liver dysfunction
What are the primary adverse effects associated with tricor/fenofibrate?
Abdominal pain, LFT increases, rhinitis
What is the brand name associated with fenofibric acid?
Trilipix
What are the contraindications/warnings associated with Trilipix?
Gallbladder disease, breast feeding, severe renal impairment, liver dysfunction
What are the primary adverse effects of Trilipix?
Nausea, headache, arthalgia, URI
What is the brand name of gemfibrozil (fibric acid)?
Lopid
What is the indication for Lopid?
Dyslipidemia
What are the contraindications/warnings associated with Lopid?
Gallbladder disease, breast feeding, severe renal impairment, liver dysfunction
What are the primary adverse effects associated with Lopid?
abdominal pain, indigestion, LFT increases
What is the brand name of lovastatin (HMG-CoA reductase inhibitor)?
Mevacor
What is the indication for Mevacor?
Dyslipidemia
What are the contraindications/warnings of Mevacor?
“Active Liver Disease (including any unexplained elevations in hepatic transaminases), pregnancy, breast-feeding,taking concurrent strong 3A4 inhibitors”
What are the primary adverse effects of Mevacor?
Abdominal pain, constipation, arthalgias, LFT increases, rhabdomyolysis, tendon rupture
What is the brand name for pravastatin SOD (HMG-CoA Reductase Inhibitor)?
Pravachol
What is the indication of Pravachol?
Dyslipidemia
What is the contraindications/warnings of Pravachol?
“Active Liver Disease (including any unexplained elevations in hepatic transaminases), pregnancy, breast-feeding, taking concurrent strong 3A4 inhibitors”
What are the primary adverse effects of Pravachol?
Diarrhea, headache, URI, LFT increase, less risk of myalgias and rhabdo
What is the brand name of Rovsuvastatin (HMG-CoA Reductase Inhibitor)
Crestor
What is the indication for Crestor?
Dyslipidemia
What are the contraindications/warnings associated with Crestor?
“Active Liver Disease (including any unexplained elevations in hepatic transaminases), pregnancy, breast-feeding, taking concurrent strong 3A4 inhibitors”
What are the primary adverse effects of Crestor?
Abdominal pain, nausea, arthralgias, myalgias, headache, LFT increases, rhabdomyolysis, tendon rupture, blood glucose increase
What is the brand name of Simvastatin (HMG-CoA Reductase Inhibitor)?
Zocor
What is the indication for Zocor?
Dyslipidemia
What are the contraindications/warnings of Zocor?
“Active Liver Disease (including any unexplained elevations in hepatic transaminases), pregnancy, breast-feeding, taking concurrent strong 3A4 inhibitors”
What are the primary adverse effects of Simvastatin?
Abdominal pain, constipation, nausea, headache, myalgias, CPK elevations, LFT elevations, BG elevation, tendon rupture
What is the brand name of Omega 3 Acid Ethyl Esters (Fish Oil)?
Lovaza
What is the indication of Lovaza?
Dyslipidemia (Triglcerides)
What are the primary adverse effects of Lovaza?
Burping, indigestion, dyspepsia, altered taste, LDL increases
What is the brand name associated with sildenafil (Phosphodiesterase-5 Enzyme Inhibitor)
Viagra
What is the indication for sildenafil?
Erectile dysfunction
What are the contraindications/warnings of sildenafil?
Concurrent use of nitrates
What are the primary adverse effects of sildenafil?
Hypotension, Prolonged erection, Priaprism, HA, Flushing, Dyspepsia, Vision changes (usually temporary)
What is the brand name of tadalafil (Phosphodiesterase-5 Enzyme Inhibitor)?
Cialis
What is the indication for tadalafil?
Erectile dysfunction
What are the contraindications/warnings of tadalafil?
Concurrent use of nitrates
What are the primary adverse effects of tadalafil?
Hypotension, Prolonged erection, Priaprism, HA, Back pain, Flushing, Dyspepsia, Vision changes (usually temporary)
What is the brand name of bimatoprost (Prostaglandin)?
Lumigan
What in the indication of bimatoprost?
Glaucoma
What are the primary adverse effects of bimatoprost?
Conjunctival hyperemia, ocular pruritis/dryness, visual distrubances, upper respiratory infections Warnings: pigmentation of iris/eyelid/eyelashes, intraocular inflammation, macular edema, bacterial keratitis
What is the brand name of latanoprost (prostaglandin)?
Xalatan
What is the indication for latanoprost?
Glaucoma