Top 300 ADRs/Warnings/CI Flashcards

Question

losartan (Cozaar)

Answer 1

HYPOtension, HYPERkalemia, INC SCr AVOID concomitant ACEi pregnancy concomitant aliskiren

Answer 2

bradycardia, HYPOtension none second or third-degree heart block decompensated HF

Answer 3

HYPOtension, peripheral edema, gingival hyperplasia none none

Answer 4

HYPOtension, dizziness INC intracranial pressure potential for severe HYPOtension concurrent use w/ PDE-5i (i.e. sildenafil) or riociguat

Answer 5

cardiac arrhythmias, peripheral ischemia ensure proper needle/catheter placement and infuse into large vein if possible to avoid extravasation none

Answer 6

eructation (burping), dyspepsia, taste perversion, elevated LDL use in CAUTION in pt w/ known fish/shellfish allergy may INC bleeding risk in pt on antiplatelet/anticoag agents none

Answer 7

bleeding NOT REC in pt w/ hx of bleeding or age >75yr active bleeding prior hx of stroke

Answer 8

bleeding, bruising INC risk of hematomas in pt undergoing neuraxial anesthesia AVOID in pt w/ mechanical heart valves active bleeding

Answer 9

hepatoxicity, muscle sx (i.e. myalgia, myopathy) none pregnancy breastfeeding unexplained elevation of serum transaminases

Answer 10

HYPOtension, HYPERkalemia, INC SCr D/C ACEi at least 36hr prior to starting Entresto hx of angioedema pregnancy concomitant ACEi or aliskiren

Answer 11

hepatotoxicity, muscle sx (i.e. myalgia, myopathy) none pregnancy breastfeeding unexplained elevation of serum transaminases AVOID strong CYP3A4/3A5 inhibitors

Answer 12

HYPERkalemia, HYPOnatremia, gynecomastia none anuria acute renal insufficiency HYPERkalemia

Answer 13

bleeding, dyspnea AVOID aspirin doses >100mg/day active bleeding

Answer 14

HYPOtension, bradycardia, constipation, gingival hyperplasia none second or third-degree heart blood HFrEF

Answer 15

bleeding , bruising purple toe syndrome (rare but serious) use CAUTION when using concomitantly w/ CYP2C9 inhibitors active bleeding pregnancy

Answer 16

sedation/drowsiness, impaired coordination, memory impairment, dysarthria may impair respiratory function (esp w/ opioids or severe pulmonary disease) may lead to abuse, misuse, and addiction may cause withdrawal reactions CAUTION when driving or operating heavy machinery CAUTION w/ CYP3A4 inhibitors may worsen depression use w/ strong CYP3A inhibitors (i.e. ketoconazole, itraconazole) EXCEPT ritonavir

Answer 17

anticholinergic side effects (constipation, xerostomia, mydriasis, urinary retention) orthostatic HYPOtension, sedation/CNS depression, SS (rare), abrupt D/C may cause withdrawal (nausea, headache, malaise) INC risk of suicidal thinking and behavior in pt aged 24 and younger may precipitate mania in pt w/ bipolar disorder may trigger angle-closure attack in glaucoma CAUTION in hx of serious CV disease CAUTION in hx of seizures risk of SS w/ other serotonergics use w/ MAOIs use / cisapride during the acute recovery phase following MI

Answer 18

EPS (esp restlessness/akathisia), N/V, somnolence, insomnia INC risk of death for elderly w/ dementia-related psychosis INC risk of suicidal thinking and behavior in pt aged 24 and younger may cause neuroleptic malignant syndrome may cause tardive dyskinesia may cause metabolic problems (e.g. DM, dyslipidemia, weight gain) may cause pathological gambling and compulsive behaviors may cause orthostatic HYPOtension may INC fall risk may cause neutropenia CAUTION in hx of seizures may impair cognition or motor skills CAUTIOM in pt at risk for aspiration pneumonia none

Answer 19

N/V, HYPERtension, tachycardia, DEC appetite, hyperhidrosis INC risk of suicidal ideation i short-term studies in children or adolescents w/ ADHD may cause severe liver injury may cause sudden death at usual doses in children and adolescents w/ structural cardiac abnormalities or other serious heart problems use w/ CAUTION in pt whose underlying medical conditions could be worsened by increases in BP or HR (HYPERtension, tachycardia, or cardiovascular or cerebrovascular disease) may cause psychotic or manic sx (e.g. hallucinations, delusional thinking, or mania) in pt w/o a hx of psychotic illness or mania pt w/ bipolar disorder or risk factors for bipolar disorder may be at INC risk of developing mania or mixed episodes may cause or worsen aggressive behavior weight and height gain of pediatric pt treated w/ atomoxetine lags behind that predicted by normative population data for about the first 9-12 months of tx may cause urinary retention/hesitation may cause priapism use w/ MAOis narrow angle glaucoma pheochromocytoma severe cardiovascular disorders

Answer 20

constipation, nausea, oral hypoesthesia risk of addiction, abuse, and misuse risk of life-threatening CNS and respiratory depression risky in combo w/ other CNS depressants or benzos accidental pediatric exposure can be dangerous may cause neonatal opioid withdrawal syndrome (NOWS) risk of adrenal insufficiency may cause withdrawal upon abrupt D/C risk of hepatitis may precipitate withdrawal if given w/ a full opioid agonist such as heroin may cause dental adverse effects may impair cognition or motor skills may cause orthostatic hypotension none

Answer 21

anorexia, dry mouth, sweating, tremor, insomnia INC risk of suicidal thinking and behavior in pt aged 24 and younger may cause seizures may cause HYPERtension may precipitate a manic, mixed, or hypomaniac manic episode may cause psychosis may trigger an angle-closure attack seizure disorder current or prior dx of bulimia or anorexia nervosa abrupt D/C of alcohol, benzos, barbiturates, and antiepileptic drugs use w/ MAOIs

Answer 22

dizziness, nausea, headache, nervousness HYPERtension when used w/ MAOIs potentially life-threatening SS w/ buspirone alone, but particularly w/ concomitant use of other serotonergic drugs interference w/ cognitive and motor performance potential for withdrawal reactions in sedative/hypnotic/anxiolytic drug-dependent pt use w/ MAOIs

Answer 23

dizziness, drowsiness/somnolence, unsteadiness/ataxia, N/V, HYPOnatremia may cause serious and sometimes fatal dermatologic reactions, including TEN and SJS may cause aplastic anemia and agranulocytosis may cause Drug Reaction w/ Eosinophilia and Systemic Sx (DRESS), AKA multiorgan hypersensitivity may cause hypersensitivity reactions in pt who previously experienced this reaction to anticonvulsants including phenytoin, primidone, and phenobarbital do NOT stop abruptly d/t risk of INC seizure frequency, including status epilepticus INC risk of suicidal thoughts or behavior may cause fetal harm when administered to pregnant women may cause HYPOnatremia hx of bone marrow suppression use w/ MAOI use w/ nefazodone use w/ delavirdine

Answer 24

N/V, sexual dysfunction, SS (rare), dose-related QT-prolongation INC risk of suicidal thinking and behavior in pt aged 24 and younger may cause dose-related QTc prolongation may precipitate ss may INC risk of bleeding events may precipitate a mixed/manic episode in pt w/ bipolar disorder may cause D/C syndrome may trigger an angle closure glaucoma attack may cause HYPOnatremia may cause sexual dysfunction use w/ MAOIs use w/ pimozide hypersensitivity to citalopram or escitalopram

Answer 25

sedation/drowsiness, impaired coordination, constipation, dysarthria use w/ opioids may result in profound sedation, respiratory depression, coma, and death risk of addiction, abuse, and misuse the continued used may lead to clinically significant physical dependence may cause somnolence and sedation may cause serious skin reactions, including SJS and TEN INC risk of suicidal thoughts or behavior none

Answer 26

sedation/drowsiness, impaired coordination, memory impairment, dysarthria, paradoxical reactions CAUTION against engaging in hazardous occupations requiring mental alertness, such as operating machinery or driving a motor vehicle concerns about the use of clonazepam during pregnancy do NOT stop abruptly d/t risk of withdrawal clinical or biochemical evidence of significant liver disease acute narrow angle glaucoma

Answer 27

sedation/somnolence, fatigue/lethargy, HYPOtension and bradycardia, contact dermatitis (transdermal ONLY) may cause dose-related DEC in BP and HR may cause somnolence and sedation abrupt D/C of clonidine can cause rebound HYPERtension in pt who have developed localized contact sensitization to clonidine transdermal system, continuation of clonidine transdermal system or substitution of oral clonidine therapy may be associated w/ the development of a generalized skin rash may worsen sinus node dysfunction and AV block, esp in pt taking other sympatholytic drugs hx of hypersensitivity reaction to clonidine

Answer 28

N/V, dry mouth, DEC appetite and weight loss, insomnia, hyperhidrosis INC risk of suicidal thinking and behavior in pt age 24 and younger may precipitate SS may INC BP may INC risk of bleeding events may trigger an angle closure glaucoma attack may cause mania/hypomania may cause D/C syndrome may cause seizures may cause HYPOnatremia may cause interstitial lung disease and eosinophilic pneumonia hypersensitivity to desvenlafaxine use w/ MAOIs

Answer 29

DEC appetite and weight loss, insomnia, N/V, headache, jittery CAUTION if hx of drug dependence or alcoholism may cause sudden death in children and adolescents w/ structural cardiac abnormalities or other serious heart problems may cause an INC in BP and HR may exacerbate sx of behavior disturbance and thought disorder in pt w/ a preexisting psychotic disorder may cause mixed/manic episode in bipolar disorder pt may cause aggressive behavior or hostility may cause suppression of growth in children may lower seizure threshold in pt w/ prior hx of seizures may cause priapism may cause peripheral vasculopathy, including Raynaud's phenomenon may cause difficulties w/ accommodation and blurring off vision marked anxiety, tension, and agitation in pt w/ galucoma, in pt w/ motor tics or FHx or dx of Tourette's syndrome during tx w/ MAOIs

Answer 30

sedation/drowsiness, impaired coordination, memory impairment, dysarthria, muscle weakness concomitant use w/ opioids may result in profound sedation, respiratory depression, coma, and death risk of addiction, abuse, and misuse may INC risk of congenital malformations and other developmental abnormalities pt w/ myasthenia gravis severe respiratory insufficiency severe hepatic insufficiency sleep apnea syndrome

Answer 31

N/V, sedation/somnolence, INC appetite/weight gain, tremor, alopecia risk of hepatoxicity esp in children <2 AVOID in women of childbearing age d/t risk of major congenital malformations, particularly neural tube defects may cause life-threatening pancreatitis hepatic disease or significant hepatic dysfunction mitochondrial disorders caused by mutations in mitochondrial DNA polymerase gamma hypersensitivity to divalproex urea cycle disorders women of childbearing potential unless other medications have failed to provide adequate sx control

Answer 32

anticholinergic side effects (constipation, xerostomia, mydriasis, urinary retention) orthostatic HYPOtension, sedation/CNS depression, SS (rare), abrupt D/C may cause withdrawal (nausea, headache, malaise) INC risk of suicidal thinking and behavior in pt aged 24 and younger parasomnias CNS depression use w/ MAOIs untreated narrow angle glaucoma severe urinary retention

Answer 33

nausea, headache, dry mouth/xerostomia, insomnia, hyperhidrosis INC risk of suicidal thinking and behavior in pt aged 24 and younger risk of hepatotoxicity may cause SS INC risk of bleeding severe skin reactions D/C syndrome syncope mania/hypomania seizures INC BP may trigger angle-closure glaucoma use w/ MAOIs

Answer 34

N/V, sexual dysfunction, SS (rare), dose-related QT-prolongation INC risk of suicidal thinking and behavior in pt aged 24 and younger may precipitate SS may INC of bleeding events may precipitate a mixed/manic episode in pt w/ bipolar disorder may cause D/C syndrome may trigger angle closure glaucoma attack may cause HYPOnatremia may cause sexual dysfunction use w/ MAOIs use w/ pimozide

Answer 35

headache, drowsiness may cause complex sleep behaviors including sleep-walking, sleep-driving, and engaging in other activities while not fully awake may impair daytime function additive effects occur w/ concomitant use of other CNS depressants may cause drowsiness and DEC level of consciousness elderly pt are at higher risk of falls complex sleep behaviors after taking eszopiclone

Answer 36

N/V, sexual dysfunction, SS (rare), dose-related QT-prolongation INC risk of suicidal thinking and behavior in pt aged 24 and younger may precipitate SS may INC risk of bleeding events may precipitate a mixed/manic episode in pt w/ bipolar disorder may cause D/C syndrome may trigger an angle closure glaucoma attack may cause HYPOnatremia may cause sexual dysfunction may cause anxiety, nervousness, or insomnia may cause weight LOSS NOT approved for children younger than 7 use w/ MAOIs use w/ pimozide use w/ thioridazine

Answer 37

dizziness, somnolence, peripheral edema, ataxia may cause Drug Reaction w/ Eosinophilia and Systemic Sx (DRESS) anaphylaxis and angioedema may impair motor skills or cognition may cause somnolence, dizziness, and ataxia INC risk of suicidal thoughts or behavior may cause respiratory depression hypersensitivity to gabapentin or its ingredients should NOT be abruptly D/C bc of possibility of INC seizure frequency in pt w/ epilepsy

Answer 38

sedation/somnolence, fatigue/lethargy, HYPOtension and bradycardia may cause dose-dependent DEC in BP and HR may worsen sinus node dysfunction and AV block may cause somnolence and sedation abrupt D/C has resulted in clinically significant and persistent rebound HYPERtension none

Answer 39

dizziness, blurry vision and diplopia, N/V, cardiac arrhythmias INC risk of suicidal thoughts or behaviors may cause dizziness and ataxia may cause cardiac arrhythmias, including bradycardia, AV block, and ventricular tachyarrhythmia should be withdrawn gradually (over a minimum of 1 week) to minimize the potential of INC seizure frequency in pt w/ seizure disorders may cause Drug Reaction w/ Eosinophilia and Systemic Sx (DRESS) none

Answer 40

dizziness, somnolence, nausea can cause serious rash, including SJS, requiring hospitalization and D/C of tx may cause hemophagocytic lymphohistocytosis (HLH) may cause Drug Reactions w/ Eosinophilia and Systemic Sx (DRESS) may slow ventricular conductions (widen QRS) and induce arrhythmias may cause blood dyscrasias (neutropenia, leukopenia, anemia, thrombocytopenia, pancytopenia) INC risk of suicidal thought and behavior should NOT be abruptly D/C (there is possibility of INC seizure frequency) in pt w/ epilepsy none

Answer 41

somnolence, asthenia, dizziness, aggression/irritability may cause behavioral abnormalities and psychotic sx may cause somnolence and fatigue AEDs INC risk of suicidal thoughts or behaviors in pt taking these drugs for any indication may cause anaphylaxis or angioedema may cause serious dermatological rxns, including SJS and TEN should NOT be abruptly D/C (there is a possibility of INC seizure frequency) may cause hematologic abnormalities none

Answer 42

insomnia, tachycardia and HTN, irritability, DEC appetite and weight loss CNS stimulants have a high potential for abuse and dependence may cause sudden death, stroke, and MI may cause INC in BP and HR may exacerbate sx of behavioral disturbance and thought disorder in pt w/ a pre-existing psychotic disorder may cause weight loss or slowing of growth rate in pediatric pr may cause peripheral vasculopathy, including Raynaud's phenomenon may cause SS when used in combo w/ other drugs that affect the serotonergic NT systems use w/ MAOIs

Answer 43

fine tremor, polyuria, peripheral edema, N/V/D, drowsiness lithium toxicity may be associated w/ diminution of renal concentrating ability, occasionally presenting as nephrogenic diabetes insipidus, w/ polyuria and polydipsia may impair mental and/or physical abilities may cause fetal harm when administered to a pregnant women should generally NOT be given to pt w/ significant renal or CVD severe debilitation or dehydration sodium depletion pt receiving diuretics

Answer 44

sedation/drowsiness, impaired coordination, memory impairment, dysarthria, paradoxical rxns concomitant use w/ opioids risk of abuse, misuse, and addiction may lead to clinically significant physical dependence INC risk of suicide in pt w/ depression caution in pt w/ compromised respiratory function (e.g. COPD, sleep apnea syndrome) acute narrow-angle glaucoma (PO only) severe respiratory insufficiency (except in those pt requiring relief of anxiety and/or diminished recall of events while being mechanically ventilated) obstructive sleep apnea (IM/IV only)

Answer 45

somnolence, nausea, EPS (esp restlessness/akathisia) elderly pt w/ dementia-related psychosis treated w/ antipsychotic drugs are at INC risk of death antidepressants INC risk of suicidal thoughts and behavior in pediatric and young adults INC risk of development of neuroleptic malignant syndrome (NMS) and tardive dyskinesia may cause metabolic changes that may INC cardiovascular/cerebrovascular risk (HYPERglycemia, dyslipidemia, and body weight gain) may cause leukopenia/neutropenia may cause orthostatic HYPOtension and syncope may cause somnolence, postural HYPOtension, motor and sensory instability should be used cautiously in pt w/ hx of seizures or w/ conditions that lower the seizure threshold has potential to impair judgement, thinking or motor skills strong CYP3A4 inhibitors strong CYP3A4 inducers

Answer 46

headache, diarrhea, dizziness, agitation and confusion (rarely) conditions that raise urine pH may DEC the urinary elimination of memantine resulting in INC plasma levels of memantine none

Answer 47

headache, insomnia, anorexia and weight loss, INC BP or HR, priapism (rare but serious) CNS stimulants have a high potential for abuse and dependence may cause sudden death, stroke, and MI may cause INC in BP and HR may exacerbate sn of behavioral disturbance and thought disorders in pt w/ a pre-existing psychotic disorder may cause weight loss and slowing of growth rate in pediatric pt may cause peripheral vasculopathy, including Raynaud's phenomenon may cause priapism concomitant tx w/ MAOIs

Answer 48

somnolence, INC appetite and weight gain, orthostatic HYPOtension and dizziness, dry mouth antidepressants INC risk of suicidal thoughts and behaviors in pediatric and young adult pt serotonergic antidepressants can precipitate SS, a potentially life-threatening condition risk is INC w/ concomitant use of other serotonergic drugs may trigger an angle-closure glaucoma attack may cause drug rxn w/ eosinophilia and systemic sx (DRESS) may cause INC risk of appetite and weight gain may cause somnolence in pt w/ bipolar disorder, treating a depressive episode w/ an antidepressant may precipitate a mixed/manic episode may cause HYPOnatremia concomitant tx w/ MAOIs

Answer 49

headache, nausea, nervousness/anxiety, INC in gamma glutamyltransferase (GGT) and alkaline phosphatase (AlkPhos) may cause serious or life-threatening rash, including SJS, TEN, and DRESS may cause angioedema and hypersensitivity may cause excessive sleepiness may cause psychiatric sx CAUTION should be exercised when modafinil is given to pt w/ hx of psychosis, depression, or mania none

Answer 50

anticholinergic SE (constipation, xerostomia, mydriasis, urinary retention), orthostatic HYPOtension, sedation/CNS depression, SS (rare), abrupt D/C may cause withdrawal (nausea, headache, malaise) INC risk of suicidal thinking and behavioral in pt aged 24 and younger may precipitate mania in pt w/ bipolar disorder may trigger angle-closure attack in glaucoma CAUTION in hx of serious CVD risk of unmasking Brugada syndrome CAUTION in hx of seizures risk of SS w/ other serotonergics concomitant tx w/ MAOIs during acute recover period after MI

Answer 51

somnolence, anticholinergic SE (constipation, xerostomia, mydriasis, urinary retention), orthostatic HYPOtension, EPS elderly pt w/ dementia-related psychosis tx w/ antipsychotic drugs are at an INC risk of death possibility of suicide attempts is inherent in schizophrenia and in bipolar I disorder, and close supervision of high-risk pt should accompany drug therapy may cause DRESS may cause neuroleptic malignant syndrome (NMS) typically antipsychotic drugs have been associated w/ metabolic changes including HYPERglycemia, dyslipidemia, and weight gain may cause tardive dyskinesia (TD) and HYPERprolactinemia may cause leukopenia/neutropenia, and rare agranulocytosis has the potential to impair judgement, thinking and motor skills none

Answer 52

dizziness, somnolence, abnormal vision (diplopia, nystagmus), HYPOnatremia may cause HYPOnatremia may cause anaphylaxis and angioedema cross hypersensitivity rxn to carbamazepine may cause serious dermatological rxns, including SJS and TEN antiepileptic drugs (AEDs) INC risk of suicidal thoughts or behavior in pt taking these drugs for any indication should be withdrawn gradually because of risk of INC seizure frequency may cause DRESS none

Answer 53

somnolence, respiratory depression, HYPOtension and bradycardia, serious skin rashes (rare) tolerance and psychological and physical dependence may occur w/ continued use elderly or debilitated pt may reaction to barbiturates should be administered w/ caution and initially in reduced doses porphyria marked impairment of liver or respiratory function

Answer 54

nausea, somnolence, constipation, sexual dysfunction INC risk of suicidal thinking and behavior in pt aged 24 and younger SS may INC risk of bleeding events may trigger an angle closure glaucoma attack may cause HYPOnatremia may precipitate a mixed/manic episode in pt at risk for bipolar disorder withdrawal concomitant tx w/ MAOI concomitant use w/ thioridazine or pimozide

Answer 55

somnolence, nystagmus, dysgeusia (metallic taste), gingival hyperplasia, dyskinesia abrupt withdrawal of phenytoin in epileptic pt may precipitate status epilepticus INC risk of suicidal thoughts or behavior may cause severe cutaneous adverse rxns (SCARs), including TEN, SJS, acute generalized exanthematous pustulosis (AGEP), and DRESS may cause bradycardia and cardiac arrest may cause angioedema may cause acute hepatotoxicity may cause thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia may cause DEC BMD (osteopenia, osteoporosis, and osteomalacia) and bone fractures may cause fetal harm when administered to pregnant women may cause HYPERglycemia

Answer 56

dizziness, somnolence, peripheral edema, ataxia may INC risk of suicidal thoughts or behavior may cause angioedema and other types of hypersensitivity may cause respiratory depression may cause dizziness and somnolence withdrawal gradually to minimize the potential of INC seizure frequency in pt w/ seizure disorders may cause peripheral edema may cause weight gain may cause blurry vision none

Answer 57

somnolence, anticholinergic SE (constipation, xerostomia, mydriasis, urinary retention), orthostatic HYPOtension, EPS elderly pt w/ dementia-related psychosis treated w/ antipsychotic drugs are at INC risk of death INC risk of suicidal thoughts and behaviors in children, adolescents, and young adults in short-term studies INC risk of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) in elderly pt may cause neuroleptic malignant syndrome (NMS) may cause metabolic changes that include HYPERglycemia/DM, dyslipidemia, and body weight gain may cause tardive dyskinesia may cause orthostatic HYPOtension may cause leukopenia/neutropenia may cause QT prolongation may cause somnolence and has potential to impair judgement, thinking or motor skills none

Answer 58

somnolence, anticholinergic SE (constipation, xerostomia, mydriasis, urinary retention), orthostatic HYPOtension, EPS elderly pt w/ dementia-related psychosis treated w/ antipsychotic drugs are at INC risk of death may cause cerebrovascular adverse events (e.g stroke, TIA) in elderly pt may cause neuroleptic malignant syndrome (NMS) may cause tardive dyskinesia may cause HYPERglycemia and DM may cause prolactinemia may cause orthostatic HYPOtension may cause leukopenia, neutropenia, and agranulocytosis may cause somnolence, w/ a potential to impair judgement, thinking, or motor skills none

Answer 59

dizziness, flushing, drowsiness, chest discomfort/pain, nausea life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported w/i a few hours following the admin of 5-HT1 agonist may cause tightness, pain, pressure, and heaviness in the precordium, throat, neck and jaw may cause cerebral hemorrhage, subarachnoid hemorrhage, and stroke may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting w/ abdominal pain and blood diarrhea), splenic infarction, and Raynaud's syndrome may cause HYPERtension ischemic coronary artery disease coronary artery vasospasm hx of stroke or TIA peripheral vascular disease ischemia bowel disease uncontrolled HTN recent use (i.e. w/i 24HR) of another 5-HT1 agonist, ergotamine-containing medication, or ergot-type medication migraine concomitant tx w/ MAOIs

Answer 60

N/V/D, sexual dysfunction, SS (rare), insomnia INC risk of suicidal thinking and behavior in pt aged 24 and younger SS may INC risk bleeding events may precipitate a mixed/manic episode in pt w/ bipolar disorder may cause D/C syndrome after abrupt D/C may trigger an angle closure glaucoma attack may cause QTc prolongation concomitant tx w/ MAOI use w/ pimozide

Answer 61

dizziness, flushing, tingling, chest discomfort/pain, nausea life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported w/ i a few hours following the administration of 5-TH1 agonist may cause tightness, pain, pressure and heaviness in the precordium, throat, neck and jaw may cause cerebral hemorrhage, subarachnoid hemorrhage, and stroke may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting w/ abdominal pain and blood diarrhea), splenic infarction, and Raynaud's syndrome may cause HYPERtension may cause seizures ischemic coronary artery disease coronary artery vasospasm hx of stroke or TIA peripheral vascular disease ischemic bowel disease uncontrolled HTN recent use (i.e. w/i 24HR) of another 5-HT1 agonist, ergotamine-containing medication, or ergot-type medication migraine concomitant tx w/ MAOIs

Answer 62

drowsiness, dizziness, hangover effect, paradoxical reactions (e.g. euphoria) use w/ opioids may result in profound sedation, respiratory depression, coma, and death risk of abuse, misuse and addiction, which can lead to overdose or death may lead to clinically significant physical dependence may cause angioedema pregnancy

Answer 63

somnolence, word-finding difficulties, DEC appetite and weight loss, nephrolithiasis may cause visual field defects and a syndrome consisting of acute myopia associate w/ secondary angle closure glaucoma may cause DEC sweating and HYPERthermia may cause metabolic acidosis INC risk of suicidal thoughts or behavior may cause fetal harm when admin to pregnant women may cause serious skin reactions (SJS, TEN) may cause HYPERammonemia w/ or w/o encephalopathy may cause kidney stones none

Answer 64

somnolence, HYPOtension, N/C, priapism INC risk of suicidal thinking and behavior in pt aged 24 and younger may precipitate SS, a potentially life-threatening condition may cause arrhythmias in pt w/ preexisting cardiac disease may cause HYPOtension may INC risk of bleeding events may cause priapism may precipitate a mixed/manic episode in bipolar pt may cause somnolence or sedation and may impair the mental and/or physical ability required for the performance of potentially hazardous tasks may trigger an angle closure glaucoma attack may cause HYPOnatremia concomitant tx w/ MAOIs

Answer 65

nausea, headache, dry mouth/xerostomia, insomnia, hyperhidrosis INC risk of suicidal thinking and behavior in pt aged 24 and younger may precipitate SS may cause HYPERtension may INC risk of bleeding events may precipitate a mixed/manic episode in pt w/ bipolar disorder may cause D/C syndrome after abrupt D/C may trigger an angle closure glaucoma attack may cause seizures may cause HYPOnatremia may cause sexual dysfunction concomitant tx w/ MAOIs pimozide

Answer 66

headache, nausea, diarrhea, sexual dysfunction INC risk of suicidal thinking and behavior in pt aged 24 and younger precipitate SS may cause arrhythmias in pt w/ preexisting cardiac disease may cause HYPOtension may INC risk of bleeding events may precipitate a mixed/manic episode in bipolar disorder pt may cause D/C syndrome may trigger an angle closure glaucoma attack may cause seizures may cause HYPOnatremia concomitant use w/ MAOIs

Answer 67

somnolence, QT-prolongation, orthostatic HYPOtension, EPS elderly pt w/ dementia-related psychosis tx w/ antipsychotic drugs are at INC risk of death INC risk of stroke and TIA in elderly pt may prolong QTc interval may cause neuroleptic malignant syndrome (NMS) may cause tardive dyskinesia may cause DRESS metabolic changes that may INC cardiovascular/cerebrovascular risk may cause HYPOtension may cause leukopenia, neutropenia, and agranulocytosis may cause HYPERprolactinemia may cause somnolence and impair judgement, thinking or motor skills known hx of QT prolongation (including congenital QT syndrome) pt w/ recent acute MI uncompensated HF

Answer 68

drowsiness, dizziness, headache may cause abnormal thinking and behavior changes may cause anaphylactic reactions has CNS-depressant effects and should only be taken immediately prior to going to bed INC sensitivity to sedative/hypnotic drugs in elderly and/or debilitated pt none

Answer 69

constipation, headache, malaise, prolonged QTc QT prolongation SS use in ileus or gastric distention may contain benzyl alcohol and derivatives associated w/ toxicity in neonates concomitant apomorphine

Answer 70

abdominal pain, acid regurgitation, constipation, diarrhea, dyspepsia upper GI ADR severe bone/joint/muscle pain risk of osteonecrosis of the jaw risk of atypical femur fractures renal impairment abnormalities of the esophagus which delay stomach emptying such as stricture or achalasia inability to stand/sit upright for at least 30 min HYPOcalcemia

Answer 71

tachycardia, confusion, blurred vision, confusion risk of anhidrosis/HYPERthermia risk of anticholinergic effects do NOT use in pt w/ tardive dyskinesia AVOID use in pt w/ glaucoma, GI obstruction or urinary retention age <3 yo

Answer 72

conjunctival HYPERemia pigmentation and reversible eyelash thickening none

Answer 73

allergic conjunctivitis, burning sensation, HYPERtension, visual disturbances, xerostomia potentiation of vascular insufficiency risk of CNS depression concurrent MOAI therapy children <2yo (higher risk of systemic adverse events)

Answer 74

dyskinesia, orthostatic HYPOtension, constipation, nausea, headache somnolence HYPERprexia and confusion compulsive behaviors narrow-angle glaucoma concurrent MAOI or linezolid w/i last 14 days

Answer 75

pruritis of ear none none

Answer 76

headache, abdominal pain, vaginal hemorrhage, breast pain, arthralgias breast cancer cardiovascular disease endometrial cancer dementia undiagnosed abnormal genital bleeding hx of estrogen- or progesterone-dependent neoplasia active or hx of DVT or PE active or hx of arterial thromboembolic disease severe liver dysfunction pregnancy known protein C, protein S, antithrombin deficiency or other known thrombophilic disorders

Answer 77

burning sensation in the eye, eye pain none active ocular infection

Answer 78

xerostomia, constipation, headache risk of angioedema gastric retention glaucoma urinary retention

Answer 79

diarrhea, nausea, insomnia, weight loss risk of rhabdomyolysis risk for GI bleeding risk of arrhythmias, SA and AV block hypersensitivity to piperidine derivatives

Answer 80

DEC libido, impotence, orthostatic HYPOtension AVOID blood donation 6 months after tx CAUTION in those w/ diminished urinary flow pregnancy

Answer 81

weight change, N/V, disturbances in mood, breast tenderness/pain, headache endometrial and breast cancer risk dementia risk should NOT be used to reduce cardiovascular disk secondary exposure risk INC risk of endometrial cancer hx of thromboembolic disorders breast cancer any estrogen-dependent neoplasm known or suspected pregnancy

Answer 82

edema, abdominal pain, depression, headache, nasopharyngitis, breakthrough bleeding endometrial and breast cancer risk dementia risk should NOT be used to reduce cardiovascular risk secondary exposure risk (transdermal solution) INC risk of endometrial cancer hx of thromboembolic disorders breast cancer any estrogen-dependent neoplasm known or suspected pregnancy

Answer 83

intermenstrual bleeding, vaginitis, headache cigarette smoking INC risk of cardiovascular events INC risk of migraine higher risk of HYPERtension hx of thromboembolic disrders endometrial cancer uncontrolled HYPERtension pregnancy smoking 15+ cigarettes per day and >35 yo

Answer 84

DEC libido, impotence, orthostatic HYPOtension AVOID blood donation 6 months after tx CAUTION in those w/ diminished urinary flow pregnancy

Answer 85

conjunctival irritation, INC lacrimation, keratitis, papillary conjunctivitis risk of resistant organisms w/ prolonged use corneal endothelial cell injury none

Answer 86

blurred vision, burning and stinging, conjunctival HYPERemia, foreign body sensation, INC pigmentation of the iris pigmentation of the iris and eyelashes INC length and thickness of eyelashes none

Answer 87

chemosis, application site burning, blurry vision, eye watering INC risk of cataracts, corneal thinning, and glaucoma active eye infection (viral, mycobacterial or fungal disease of the eye)

Answer 88

amenorrhea, weight gain, abdominal pain, headache, nervousness NOT used for prevention of cardiovascular disorders (PO) INC risk of breast cancer (PO) NOT used for DEC risk of dementia (PO) NOT rec for long-term use (>2 years - INJ) risk of loss of BMD (INJ) risk vs benefit (PO) cardiovascular, dementia risk loss of BMD breast cancer abnormal genital bleeding hx of estrogen- or progesterone-dependent neoplasia active or hx of DVT or PE severe liver dysfunction known or suspected pregnancy

Answer 89

conjunctivitis, eye irritation risk of superinfection w/ prolonged use none

Answer 90

constipation, xerostomia, blurred vision, drowsiness use w/ CAUTION in those w/ dementia and HYPERthyroidism gastric retention glaucoma urinary retention

Answer 91

nausea, alopecia, diarrhea risk of INC bleeding pigmentary changes in retina none

Answer 92

asthenia, dyskinesia, nausea, somnolence, constipation dyskinesia may execerbate psychotic disorders none

Answer 93

fluid retention, headache, amenorrhea, breast tenderness, abdominal pain NOT used for prevention of cardiovascular disorders (PO) INC risk of breast cancer (PO) NOT used for DEC risk of dementia (PO) risk vs benefit (PO) abnormal vaginal bleeding hx of estrogen- or progesterone-dependent neoplasia active or hx of DVT or PE known or suspected pregnancy (PO)

Answer 94

dizziness, N/V, HYPOtension, somnolence dyskinesias CAUTION in those w/ CVD (elevates BP) none

Answer 95

flushing, headache, visual disturbances, dyspepsia impairment of color discrimination risk of HYPOtension w/ concurrent alcohol use CAUTION in those w/ CVD concurrent nitrates concurrent HIV protease inhibitors when used for treating pulmonary HYPERtension concurrent guanylate cyclase stimulators

Answer 96

constipation, xerostomia, blurred vision risk of angioedema QT prolongation CAUTION in those w/ DEC GI motility and bladder outlet obstruction (BPH) gastric retention uncontrolled glaucoma urinary retention

Answer 97

diarrhea, headache, HYPERtension, elevated BG (DM), HYPERkalemia, neurological sx (tremors, numbness, seizures, confusion), anemia, OI, nephrotoxicity risk of infection risk of malignancies INC mortality in female transplant pt w/ Astagraf XL Astagraf XL NOT approved for liver transplant hypersensitivity to HCO-60

Answer 98

flushing, headache, visual disturbances, dyspepsia, myalgias impairment of the color discrimination risk of HYPOtension w/ concurrent alcohol use CAUTION in those w/ CVD risk of sudden DEC or loss of hearing concurrent nitrates concurrent guanylate cyclase stimulators

Answer 99

drowsiness, restlessness tardive dyskinesia depression and suicidal ideation risk of neuroleptic malignant syndrome situations when GI stimulation may be dangerous (GI hemorrhage, mechanical obstruction or perforation) pheochromocytoma concomitant use w/ drugs likely to cause extrapyramidal reactions epilepsy hx of tardive dyskinesia

Answer 100

agitation, insomnia, fluid retention, HYPERglycemia, peptic ulcer, myopathy, cataracts/glaucoma adrenal suppression CAUTION in those w/ GI diseases (peptic ulcer, UC) administration of live vaccines w/ immunosuppressive dose of prednisone fungal infections

Answer 101

orthostatic HYPOtension, abnormal ejaculation, dizziness, headache, rhinitis risk of floppy iris syndrome CAUTION in those w/ sulfonamide allergy none

Answer 102

xerostomia risk of QT prolongation CAUTION in those w/ bladder flow obstruction CAUTION in those w/ glaucoma fesoterodine gastric retention uncontrolled narrow-angle glaucoma urinary retention

Answer 103

ocular HYPERemia, eye pain may produce eye color changes risk of ocular inflammation none

Answer 104

flushing, headache, rhinitis impairment of color discrimination risk of HYPOtension w/ concurrent alcohol use CAUTION in those w/ CVD risk of vision/hearing loss concurrent nitrates concurrent guanylate cyclase stimulators

Answer 105

HYPERtension (low risk w/ topical route), polycythemia, PSA INC, application site blistering (topical) BP INC (PO, SQ) pulmonary oil microembolism (IM) secondary exposure (topical) may INC risk of depression or suicidal ideation CAUTION in those w/ hepatic or renal impairment concurrent nitrates concurrent HIV protease inhibitors when used for treating pulmonary HYPERtension concurrent guanylate cyclase stimulators

Answer 106

hot flashes, flu-like sx, arthralgias, leg cramps, edema venous thromboembolism stroke pregnancy/lactation men premenopausal women concurrent hormone replacement therapy active or hx of venous thromboembolism

Answer 107

infection, arthralgia, diarrhea, headache, UTI, skin rash upper GI adverse reactions severe bone/joint/muscle pain risk of osteonecrosis of the jaw risk of atypical femur fractures renal impairment abnormalities of the esophagus which delay emptying such as stricture or achalasia inability to stand/sit upright for at least 30ming HYPOcalcemia

Answer 108

skin rash, infection, antibody development, injection site reactions, diarrhea infections malignancies tuberculosis antibody formation demyelinating CNS disease sepsis

Answer 109

abdominal pain, diarrhea, dizziness, visual disturbances, HYPERpigmentation porphyria psoriasis pediatric pt hypersensitivity

Answer 110

myelosuppression, N/V, oral mucosal ulcer, hepatotoxicity serious adverse effects are possible including bone marrow suppression, serious infections, renal toxicity, GI toxicity, hepatic toxicity, pulmonary toxicity and dermatologic reactions fetal toxicity pregnancy tumor lysis syndrome radiotherapy secondary malignancy breastfeeding in pt treated for psoriasis and RA - preexisting blood dyscrasias, pregnancy, alcoholism, alcoholic liver disease, immunodeficiency syndromes

Answer 111

bradycardia, HYPOtension, HYPOglycemia unawareness, bronchoconstriction/SOB, fatigue use w/ CAUTION in HF asthma sinus bradycardia heart block greater than 1st degree sick sinus syndrome cardiogenic shock uncompensated HF

Answer 112

INC BP, palpitations/tachyarrhythmia, insomnia, tremor, restlessness renal impairment seizures CVD hypersensitivity to phentermine or other sympathomimetic amines use in agitates states CVD - arrythmias, HF, CAD, stroke, uncontrolled HTN hx of drug abuse glaucoma HYPERthyroidism concomitant use w/ MAOIs - at least 14 days should elapse between use of phentermine and MAOIs pregnancy lactation

Answer 113

nausea, headache, fatigue risk of HepB reactivation in pt coinfected w/ HCV and HBV use w/ amiodarone, p-glycoprotein inducers, or moderate to potent CYP2B6, CYP2C8 or CYP3A4 inducers NOT rec none

Answer 114

nausea, headache, fatigue risk of HepB reactivation in pt coinfected w/ HCV and HBV concomitant use w/ carbamazepine, efavirenz, or St John's wort is NOT rec moderate or severe hepatic impairment (Child-Pugh B or C) or those w/ any hx of prior hepatic decompensation concomitant use w/ atazanavir or rifampin

Answer 115

peripheral edema, dizziness, fatigue, nausea, pruritus superinfection - C. diff infection risk hypersensitivity to rifaximin/rifamycins

Answer 116

HYPERtension, GI upset, INC risk of infection, weight gain adrenal suppression/insufficiency CVD GI disease pheochromocytoma concurrent use of live or live attenuated vaccines fungal infections

Answer 117

HYPERtension, GI upset, INC risk of infection, HYPERglycemia, weight gain adrenal suppression/insufficiency hepatic disease immunosuppression CVD GI disease concurrent use of live or live attenuated vaccines fungal infections intrathecal administration administration to premature infants immune thrombocytopenia

Answer 118

HYPERtension, GI upset, INC risk of infection, HYPERglycemia, weight gain adrenal suppression/insufficiency hepatic disease immunosuppression CVD GI disease concurrent use of live or live attenuated vaccines

Answer 119

abdominal pain, leukopenia, antibody development, injection site reactions, flu-like sx, INC LFTs autoimmune disorders bone marrow suppression hepatic toxicity tuberculosis injection site reactions neuropsychiatric disorders (depression) hypersensitivity to human albumin

Answer 120

tremor, nervousness, tachycardia paradoxical bronchospasm none

Answer 121

worsening gout at first, maculopapular rash SJS toxic epidermal necrolysis hepatotoxicity immune hypersensitivity reaction renal failure none

Answer 122

bitter taste in mouth headache somnolence none none

Answer 123

weakness, dizziness, vertigo, drowsiness, withdrawal syndrome abrupt withdrawal - especially w/ the intrathecal route AVOID in pt w/ psychiatric and seizure disorders injecting IV, IM, SQ, or epidural administration

Answer 124

oral candidiasis, hoarseness may cause a reduction in growth velocity in pediatric pt INC risk of pneumonia in COPD pt paradoxical bronchospasm none

Answer 125

oral candidiasis, hoarseness, tremor, nervousness may cause a reduction in growth velocity in pediatric pt INC risk of pneumonia in COPD pt paradoxical bronchospasm none

Answer 126

dizziness, drowsiness, headache, rare but serious: seizures CNS depression: may impair physical or mental abilities concomitant use of other CNS depressants acute intermittent porphyria seizures hypersensitivity to carbamates

Answer 127

AKI, INC bruising or bleeding, GI upset (less than other NSAIDs) serious cardiovascular risk - including MI and stroke, which can be fatal serious GI events - including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal CYP2C9 substrate hypersensitivity (e.g. anaphylaxis, serious skin reactions) to celecoxib, sulfonamides, aspirin, other NSAIDs (though sulfa cross reactivity is questionable)

Answer 128

pruritis none none

Answer 129

GI issues (N/V/D) biliary obstruction renal impairment hepatic disease renal disease concomitant use of P-glycoprotein or CYP3A4 inhibitor and colchicine in the presence of renal or hepatic impairment

Answer 130

anticholinergic SE - urinary hesitancy, constipation, dizziness, drowsiness No boxed warnings risk for arrhythmias and QTc prolongation risk for SS MAOIs arrhythmias heart block of conduction disturbances acute recovery phase of MI AVOID in pt w/ HF

Answer 131

stomach pain and diarrhea, C. diff diarrhea, HYPOmagnesemia none none

Answer 132

AKI, INC bruising and bleeding, GI upset (less than other NSAIDs), INC liver enzymes serious cardiovascular risk - including MI and stroke, which can be fatal serious GI events - including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal hx of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs major substrate of CYP2C9

Answer 133

anticholinergic SE - urinary hesitancy, constipation, dizziness, drowsiness, tachycardia NO boxed warnings psychosis/delirium: in pt w/ an extreme sensitivity to anticholinergic effects or at excessive dosages, such as the elderly or pt w/ mental illness obstructive diseases of the GI tract severe UC reflux esophagitis obstructive uropathy glaucoma myasthenia gravis breastfeeding women infants <6 months of age

Answer 134

flushing, tachycardia, confusion, abdominal distress NO boxed warnings atropinism CNS depression slow GI mobility hypersensitivity to drug or its components obstructive jaundice C. diff diarrhea

Answer 135

abdominal pain, C. diff diarrhea, headache, HYPOmagnesemia none none

Answer 136

AKI, INC bruising or bleeding, GI upset (less than other NSAIDs), pancreatitis, INC liver enzymes serious cardiovascular risk - including MI and stroke, which can be fatal serious GI events - including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal risk for SJS or DRESS hypersensitivity (e.g. anaphylaxis, serious skin reactions) to etodolac, aspirin, other NSAIDs

Answer 137

constipation, diarrhea, nausea, skin rash none none

Answer 138

constipation, respiratory depression, opioid withdrawal, CNS depression, dependence life threatening respiratory depression abuse, addiction, and misuse accidental exposure cytochrome P450 CYP3A4 interactions neonatal opioid withdrawal syndrome concomitant use of opioids w/ benzos or other CNS depressants substantial differences exist in the pharmacokinetic profile of fentanyl buccal, intranasal, lozenge, and sublingual REMS program exposure to heat (patch only) significant respiratory depression GI obstruction, including paralytic ileus (known or suspected) pt requiring short-term therapy, management of acute of intermittent pain, postoperative or mild pain pt who are NOT opioid tolerant

Answer 139

oral candidiasis, hoarseness, paradoxical bronchospasm may cause a reduction in growth velocity in pediatric pt INC risk of pneumonia in COPD pt paradoxical bronchospasm none

Answer 140

oral candidiasis, hoarseness, tremor, nervousness, paradoxical bronchospasm may cause a reduction in growth velocity in pediatric pt INC risk of pneumonia in COPD pt paradoxical bronchospasm none

Answer 141

constipation, respiratory depression, opioid withdrawal, CNS depression, dependence addiction, abuse and misuse REMS program life threatening respiratory depression accidental ingestion neonatal opioid withdrawal syndrome cytochrome P450 3A4 interactions risk from concomitant use w/ benzos or other CNS depressants interaction w/ alcohol significant respiratory depression GI obstruction, including paralytic ileus (known or suspected)

Answer 142

tremor, nervousness, tachycardia, bitter metallic taste, xerostomia paradoxical bronchospasm none

Answer 143

skin irritation, hair loss w/ shampoo, application site reaction w/ foam, rash none none

Answer 144

abdominal pain, C. diff diarrhea, headache, HYPOmagnesemia none none

Answer 145

tremor, nervousness, tachycardia paradoxical bronchospasm none

Answer 146

skin irritation, somnolence none hypersensitivity to lidocaine

Answer 147

headache, nausea, diarrhea HYPOtension syncope hypersensitivity bowel obstruction

Answer 148

AKI, INC bruising or bleeding, GI upset (less than other NSAIDs), INC liver enzymes serious cardiovascular risk - including MI and stroke, which can be fatal serious GI events - including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal risk for SJS CYP2C9 substrate hypersensitivity to meloxicam hx of asthma, urticaria or other allergic-type reactions after taking aspirin or other NSAIDs

Answer 149

dizziness/drowsiness, irritability/nervousness, hemolytic anemia, leukopenia, liver enzyme elevations CNS depression SS significantly impaired hepatic or renal function tendency to drug-induced, hemolytic or other anemias

Answer 150

constipation, respiratory depression, opioid withdrawal, CNS depression, QTc prolongation addiction, abuse or misuse REMS program life threatening respiratory depression QT prolongation accidental ingestion neonatal opioid withdrawal syndrome requires supervision for detoxification and maintenance for opioid dependence CYP interactions: 3A4, 2B6, 2C19, 2C9, or 2D6 concomitant use of opioids w/ benzos or other CNS depressants risk of medication errors 1mg/mL solution and 2mg/mL solution significant respiratory depression GI obstruction, including paralytic ileus (known or suspected)

Answer 151

N/A none hypersensitivity to methocarbamol or any component of the formulation renal impairment

Answer 152

headache, pharyngitis, nasal irritation and burning, epistaxis none none

Answer 153

headache, upper respiratory tract infections, nausea neuropsychiatric events including agitation, aggression, depression, sleep disturbances, suicidal thoughts/behaviors none

Answer 154

constipation, respiratory depression, opioid withdrawal, CNS depression, pruritus monitor pt for at least 24HR in a fully equipped and staffed environment if giving intrathecal or epidural ethanol use addiction, abuse, and misuse REMS life threatening respiratory depression neonatal opioid withdrawal syndrome accidental ingestion multiple concentrations of oral solution risk from concomitant use w/ benzos or other CNS depressants significant respiratory depression GI obstruction, including paralytic ileus (known or suspected)

Answer 155

AKI, INC bruising or bleeding, GI upset (less than other NSAIDs), INC liver enzymes serious cardiovascular risk - including MI and stroke, which can be fatal serious GI events - including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal hypersensitivity to nabumetone or any component of the formulation, urticaria or allergic-type reactions after taking aspirin or other NSAIDs use in setting of coronary artery bypass graft surgery

Answer 156

abdominal pain, C. diff diarrhea, headache, HYPOmagnesemia none none

Answer 157

constipation, respiratory depression, opioid withdrawal, CNS depression, dependence addiction, abuse and misuse REMS life-threatening respiratory depression accidental ingestion neonatal opioid withdrawal cytochrome P450 3A4 interaction risk from concomitant use w/ benzos risk of medication errors w/ multiple formulations of the oxycodone significant respiratory depression GI obstruction, including paralytic ileus (known or suspected)

Answer 158

abdominal pain, C. diff diarrhea, headache, HYPOmagnesemia none none

Answer 159

GI - abdominal pain and cramping, bloating and diarrhea NO boxed warnings prolonged use may cause electrolyte disturbances stop using if diarrhea occurs known or suspected bowel obstruction

Answer 160

abdominal pain, C. diff diarrhea, headache, HYPOmagnesemia none none

Answer 161

constipation none none

Answer 162

xerostomia, cough paradoxical bronchospasm none

Answer 163

hepatotoxicity, HYPOtension, sedation, withdrawal syndrome no boxed warnings AVOID in hepatic and renal impairment AVOID in older adults concomitant therapy w/ potent CYP1A2 inhibitors (e.g. ciprofloxacin, fluvoxamine)

Answer 164

constipation, respiratory depression, opioid withdrawal, CNS depression, seizure and SS risk of medication errors addiction, abuse and misuse REMS program life threatening respiratory depression accidental ingestion ultra-rapid metabolism of tramadol neonatal opioid withdrawal syndrome interactions w/ drugs affect cytochrome P450 enzymes risk from concomitant use w/ benzos hypersensitivity to tramadol, opioids or any component of the formulation use in pediatric pt <12yo significant respiratory depression concomitant use w/i 14 days of an MAOI

Answer 165

nasal irritation and burning, headache, pharyngitis, epistaxis, taste perversion none none

Answer 166

dry skin, burning sensation, stinging, pruritis/atrophy at site of administration none none

Answer 167

N/V, constipation, flatulence, sleep disturbances (insomnia, abnormal dreams) serious neuropsychiatric events seizure MI hypersensitivity

Answer 168

sedation, headache, dry mouth fatigue none documented hypersensitivity or related product product including cetirizine and levocetirizine and components of the formulation QT prolongation

Answer 169

nephrotoxicity through crystalluria or acute interstitial nephritis (AIN) --> hydrate w/ NS and use adjBW in obesity (BMI >30) to not overdose, neurotoxicity (confusion, agitation, hallucinations) --> AVOID in pt w/ underlying neurological conditions, nausea, diarrhea, rash extravasation w/ IV acyclovir (rotate infusion sites) tx should begin ASAP w/i 72HR of first dx and 24HR of recurrent episode buccal tab: hypersensitivity to milk protein concentrate

Answer 170

nephrotoxicity through crystalluria or acute interstitial nephritis (AIN) --> hydrate w/ NS and use adjBW in obesity (BMI >30) to not overdose, neurotoxicity (confusion, agitation, hallucinations) --> AVOID in pt w/ underlying neurological conditions, thrombotic thrombocytopenic purpura (TTP) w/ valacyclovir in immunosuppressed pt, nausea, diarrhea, rash tx should begin ASAP w/i 72HR of first dx and 24HR of a recurrent episode none

Answer 171

headache, elevated LFTs, AVOID in pregnancy or while breastfeeding, GI discomfort bone marrow suppression LFT elevation do NOT use in pregnancy or while breast feeding none

Answer 172

insomnia, depression, myalgia, weight gain hepatotoxicity rash false elevation of SCr w/i 1-2 weeks w/ no effect on GFR INC CPK concurrent use w/ dofetilide

Answer 173

emtricitabine-associated hyperpigmentation, bictegravir may cause transient elevation of SCr w/ no effect of GFR, tenofovir alafenamide (TAF) may DEC BMD, TAF may cause renal impairment (AVOID CrCl <30), TAF may cause HYPERlipidemia, TAF if preferred over its other salt form tenofovir disoproxil fumarate (TDF) whenever possible hepatomegaly w/ steatosis and lactic acidosis concurrent use w/ dofetilide and rifampin

Answer 174

DEC BMD (less than TDF), renal impairment (AVOID in CrCl <30), higher incidence of HYPERlipidemia than TDF, preferred over TDF whenever possible severe exacerbation of HepB hepatomegaly w/ steatosis and lactic acidosis renal impairment - AVOID ise in CrCl <30 when used for HepB, need to rule out co-infection w/ HIV-1 IRIS (immune reconstitution syndrome) can occur none

Answer 175

weight gain, INC cholesterol and TG, abnormal vivid dreams, many DDI (CYP 450 substrate and inhibitor), teratogenic, resistance associated w/ mutations in HIV CNS SE (abnormal dreams, insomnia, impaired concentration, hallucinations) psychiatric SE (depression, delusions, suicidal ideations) fat redistribution (e.g. central obesity) hepatotoxicity QT prolongation HYPERcholesterolemia rash including SJS do NOT administer w/ elbasvir, grazoprevir, midazolam, St John's wort or ergot alkaloids

Answer 176

DEC BMD, renal impairment (do NOT use in CrCl <50), hyperpigmentation, rash, HYPERglycemia, HYPERlipidemia, HYPOphosphatemia, upper respiratory tract infection acute exacerbation of HepB lactic acidosis and hepatomegaly w/ steatosis do NOT use to treat HIV do NOT used as PEP in pt w/ unknown HIV status

Answer 177

INC LFTs, acute exacerbation of HepB after D/C, DDI - do NOT use concurrently w/ ribavarin d/t hepatoxicity or ganciclovir d/t hematologic toxicity HIV resistance in chronic HepB pt w/ undiagnosed HIV co-infection do NOT use in HIV positive pt lactic acidosis and hepatomegaly w/ steatosis none

Answer 178

hepatotoxicity, skin rash, CNS effects (dizziness or even seizures), DDI - AVOID concurrent use w/ agents that prolong QTc (QTc prolongation), HMG-CoA reductase inhibitors (rhabdomyolysis), or sulfonylureas (HYPOglycemia) renail impairment (dose adjust if CrCl <50) some dosage forms may contain benzyl alcohol associated w/ "gasping syndrome" do NOT use doses >400mg/d in pregnancy QT prolongation if administered w/ CYP3A4 substrates concurrent ergot alkaloids

Answer 179

infusion reactions (phlebitis, pruritis, facial swelling), abnormal LFTs, fever, AVOID co-administration w/ sirolimus histamine-mediated infusion related reactions phlebitis w/ IV administration hepatotoxicity none

Answer 180

GI SE (N/V/D, stomach pain), skin irritation or rash topical formulations are for external use only - do NOT get into eyes, nose, or mouth none

Answer 181

GI SE - N/V, suspension contains sorbitol, which can cause diarrhea in fructose intolerance, neuropsychiatric SE - confusion, delirium, hallucinations can occur, headache renal impairment (dose adjust in CrCl <60) none

Answer 182

GI (N/V/D), rash infective mononucleosis (because of rash) hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to amoxicillin or other beta-lactams

Answer 183

GI (diarrhea), rash d/t differing content of clavulanate, NOT all formulations are interchangeable d/t clavulanate content hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to amoxicillin, beta-lactamase inhibitors, or other beta-lactams hx of cholestatic jaundice or hepatic dysfunction w/ amoxicillin/clavulanate

Answer 184

GI (N/V/D), rash, phlebitis (IV) use w/ CAUTION w/ severe renal impairment and in those w/ seizure disorders electrolyte imbalance (HYPERkalemia w/ penicillin G potassium and HYPERnatremia and HF w/ penicillin G sodium), hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to penicillin or other beta-lactams

Answer 185

GI (N/V/D), rash, phlebitis electrolyte imbalance (HYPERnatremia d/t sodium content in piperacillin) hypersensitivity reactions (including anaphylaxis) may INC risk of nephrotoxicity w/ vancomycin serious hypersensitivity to piperacillin, beta-lactamase inhibitors or other beta-lactams

Answer 186

GI (N/V/D), rash, seizures, phlebitis CNS effects (seizures, confusion) - dose modify in renal impairment to minimize may DEC valproic acid levels hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to imipenem/cilastatin or other beta-lactams

Answer 187

GI (N/V/D), rash hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to cephalexin or other beta-lactams

Answer 188

GI (N/V/D), rash iron containing products: may cause red stools hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to cefdinir or other beta-lactams

Answer 189

GI (N/V/D), rash, phlebitis hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to cefazolin or other beta-lactams

Answer 190

GI (N/V/D), rash, gallbladder sludge (pseuocholelithiasis), C. diff infection, injection site reaction (induration, warmth, tightness) hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to ceftriaxone or other beta-lactams HYPERbilirubinemia in neonates concomitant use w/ IV calcium-containing solution in neonates IV use of ceftriaxone w/ lidocaine solutions

Answer 191

GI (N/V/D), rash, positive direct Coombs test (w/o hemolysis), CNS (seizures, confusion) hypersensitivity reactions (including anaphylaxis) CNS effects (seizures, confusion) - dose modify in renal impairment to minimize serious hypersensitivity to cefepime or other beta-lactams

Answer 192

GI (N/V/D), rash, phlebitis (IV), INC LFTs hypersensitivity reactions (including anaphylaxis) serious hypersensitivity to cefuroxime or other beta-lactams

Answer 193

tendinitis and tendon rupture, CNS effects, cardiac (QT prolongation), HYPO/HYPERglycemia, dermatologic, aortic dissection and rupture, C. diff colitis serious ADRs (tendinitis and tendon rupture, peripheral neuropathy, CNS effects, cardiac (QT prolongation), HYPO/HYPERglycemia, dermatologic) may exacerbate muscle weakness in myasthenia gravis aortic dissection and rupture NOT generally used in children <16yo d/t joint cartilage injury hypersensitivity to ciprofloxacin or other quinolones concurrent administration of tizanidine

Answer 194

tendinitis and tendon rupture, CNS effects, cardiac (QT prolongation), HYPO/HYPERglycemia, dermatologic, aortic dissection and rupture, C. diff colitis serious ADRs (tendinitis and tendon rupture, peripheral neuropathy, CNS effects, cardiac (QT prolongation), HYPO/HYPERglycemia, dermatologic) may exacerbate muscle weakness in myasthenia gravis aortic dissection and rupture NOT generally used in children <16yo d/t joint cartilage injury hypersensitivity to levofloxacin or other quinolones concurrent administration of tizanidine

Answer 195

tendinitis and tendon rupture, CNS effects, cardiac (QT prolongation), HYPO/HYPERglycemia, dermatologic, aortic dissection and rupture, C. diff colitis serious ADRs (tendinitis and tendon rupture, peripheral neuropathy, CNS effects, cardiac (QT prolongation), HYPO/HYPERglycemia, dermatologic) may exacerbate muscle weakness in myasthenia gravis aortic dissection and rupture NOT generally used in children <16yo d/t joint cartilage injury hypersensitivity to moxifloxacin or other quinolones concurrent administration of tizanidine

Answer 196

GI (N/V/D), INC LFTs, myasthenia gravis, QTc prolongation QT prolongation myasthenia gravis hepatic effects hypersensitivity reactions hypersensitivity to azithromycin or any macrolide or ketolide antibiotic hepatic dysfunction w/ prior azithromycin therapy

Answer 197

GI (N/V/D), taste disturbance, INC LFTs, myasthenia gravis, QTc prolongation QT prolongation myasthenia gravis hepatic effects hypersensitivity reactions hypersensitivity to clarithromycin or any macrolide or ketolide antibiotic concomitant use w/ cisapride, pimozide, colchicine (in renal or hepatic impairment), lomitapride, lovastatin, simvastatin, ergotamine dihydroergotamine hx of cholestatic jaundice or hepatic dysfunction

Answer 198

GI (N/V, abdominal pain, GI hemorrhage, bowel obstruction), hematologic (anemia, neutropenia), hypersensitivity hypersensitivity reactions macrolide allergy do NOT use for system infections hypersensitivity to fidaxomicin or component in the formulation

Answer 199

GI (N/V/D), erosive esophagitis, photosensitivity reactions, tooth discoloration and abnormal skeletal development in children <8yo (but can be used safely for <22days) photosensitivity reactions tooth discoloration and abnormal skeletal development in children <8yo (but can be used safely for <22days) intracranial HYPERtension hypersensitivity to doxycycline, other tetracyclines, or any component of the formulation

Answer 200

GI (N/V/D), dizziness and vertigo, tissue hyperpigmentation (slate-gray or blue-black coloration of the skin), photosensitivity reactions, tooth discoloration and abnormal skeletal development in children <8yo photosensitivity reactions tooth discoloration and abnormal skeletal development in children <8yo intracranial HYPERtension hypersensitivity to minocycline, other tetracyclines, or any component of the formulation

Answer 201

GI (N/V/D), C. diff colitis, esophagitis, rash colitis hypersensitivity to clindamycin, lincomycin, or any component of the formulation

Answer 202

GI (N/V/D), hematologic (thrombocytopenia, anemia, neutropenia), neuropathy (optic, peripheral), INC LFTs myelosuppression SS neuropathy (peripheral and optic) HYPOglycemia C. diff hypersensitivity to linezolid or any component of the formulation concurrent use or w/i 2 weeks MAOIs

Answer 203

dermatologic (rash, severe hypersensitivity such as SJS), hematologic (pancytopenia, hemolytic anemia), renal failure, arrhythmias, HYPERkalemia glucose-6-phosphate dehydrogenase deficiency (G6PD) (hemolysis) hypersensitivity to sulfonamides children <2mo pregnant pt at term megaloblastic anemia d/t folate deficiency hx of drug-induced thrombocytopenia w/ use of sulfonamides or trimethoprim marked hepatic damage or severe renal disease concomitant administration w/ dofetilide

Answer 204

GI (N/V/D, abnormal taste), hypersensitivity reactions (rash, severe such as SJS), neuropathy carcinogenic (rats, mice) hypersensitivity to metronidazole

Answer 205

discoloration of urine (brown color), GI (N/V/D), interstitial pneumonitis w/ progressive fibrosis, hypersensitivity reactions G6PD deficiency (hemolysis) renal impairment (short-term use ok w/ CrCl 30-60) hypersensitivity to nitrofurantoin use in neonates or pregnant pt at term (38-42 weeks) d/t risk of hemolytic anemia, anuria, or oliguria

Answer 206

IV: renal failure, ototoxicity, vancomycin histamine release syndrome (vancomycin infusion reaction), rash, phlebitis, DRESS, hematologic (thrombocytopenia, neutropenia) PO: nausea, abdominal pain, HYPOkalemia use w/ CAUTION in renal impairment (INC risk of nephrotoxicity) hypersensitivity to vancomycin or any component of formulation

Answer 207

hot flashes, mood changes, weakness, arthralgia, osteoporosis INC ischemic cardiac events in women w/ pre-existing cardiac disease DEC BMD INC cholesterol levels hypersensitivity women of premenopausal endocrine status (including pregnant women)

Answer 208

hot flashes, irregular periods, vaginal discharge, peripheral edema, mood changes, weakness, arthralgia INC risk of uterine malignancies and thromboembolic events risk of embryo-fetal toxicity and liver abnormalities tamoxifen is a pro-drug activated mainly through CYP2D6, utilize 2D6 inhibitors/induces w/ CAUTION hypersensitivity do NOT administer w/ warfarin in pt w/ a hx of DVT/PE, tamoxifen is also CI if the indications for tx if either reduction of breast cancer incidence in high-risk pt or risk reduction of invasive breast cancer after tx of DCIS

Answer 209

HTN, thrombosis (including DVT), injection site reactions, pure red cell aplasia, seizures, SJS and TEN erythropoiesis-stimulating agents (ESAs) INC the risk of serious cardiovascular events, MI, stroke, venous thromboembolism (VTE), vascular access thrombosis, and mortality in clinical studies when administered to target Hb levels >11 g/dL ESAs shortened overall survival and/or INC risk of tumor progression or recurrence in clinical studies of pt w/ breast, non-small cell lung, head and neck, lymphoid, and cervical cancers to DEC these risks, as well as risk of serious cardiovascular and thromboembolic reactions, use lowest dose needed to avoid RBC transfusions use ESAs only for anemia from myelosuppressive chemo ESAs are NOT indicated for pt receiving myelosuppressive chemo when anticipated outcome is cure D/C following the completion of chem course perisurgical: d/t risk of DVT, DVT ppx is recommended AVOID use in HF and uncontrolled HTN use CAUTION in pt w/ hx of seizures serious allergic reactions uncontrolled HTN pure red cell aplasion

Answer 210

hepatotoxicity alcoholism hepatic impairment limit dose from all sources/routes to <4g/day hepatic disease or impairment hypersensitivity

Answer 211

edema, INC BP, abdominal discomfort, heartburn may INC risk of ASCVD events INC risk of GI events/bleeding CAUTION in older adults d/t GI bleeds CAUTION in HTN, fluid retention, and HF INC risk of renal injury AVOID in pregnancy NSAID allergy or hypersensitivity CABG surgery

Answer 212

edema, INC BP, abdominal discomfort, heartburn may INC risk of ASCVD events INC risk of GI events/bleeding CAUTION in older adults d/t GI bleeds CAUTION in HTN, fluid retention, and HF INC risk of renal injury AVOID in pregnancy NSAID allergy or hypersensitivity CABG surgery

Answer 213

INC BP, dyspnea/GI ulcer, confusion, Reye's syndrome, dizziness AVOID chronic use >325mg/day in elderly GI bleed INC bleeding risk AVOID in severe liver disease AVOID if GFR <10 AVOID in pregnancy asthma rhinitis nasal polyps syndrome

Answer 214

fatigue, dizziness do NOT use in children <2yo CAUTION in cough w/ excessive secretions MAOI use concurrently or w/i 14 days

Answer 215

dizziness, drowsiness, dyskinesia, anticholinergic SE, xerostomia AVOID in elderly d/t strong anticholinergic effects CAUTION in glaucoma CAUTION in BPH excitation may occur in children newborns/premature infants nursing mothers

Answer 216

N/V AVOID in children <2yo CAUTION in cough w/ excessive secretions none

Answer 217

HTN, tachycardia, insomnia, anxiety, MI CAUTION in HTN, glaucoma, HYPERthyroidism, ischemia heart disease, BPH, arrhythmias CAD HTN MAOI use concurrently or w/i 14 days

Answer 218

headache, nasal irritation and burning, epistaxis, glaucoma immunosuppression w/ prolonged use nasal effects (nasal alteration, nasal erosion, epistaxis) N/A

Answer 219

headache CAUTION in hepatic and renal impairment none

Answer 220

headache, sedation, dry mouth, nausea, insomnia CAUTION in renal impairment do NOT administer at same time w/ aluminum or magnesium antacids or w/ fruit juices none

Answer 221

drowsiness CAUTION in hepatic and renal impairment older pt may become more sensitive to SE none

Answer 222

dry nose, sneezing, nasal irritation local nasal effects rebound nasal congestion do NOT use >3 days

Answer 223

patch: dermatological SE (erythema, pruritis, burning), sleep disturbances gum and lozenge: mouth/throat irritation, hiccups, GI (dyspepsia, nausea), lightheadedness especially if NOT used correctly gum ONLY: jaw muscle aches, may stick to dental work ideally, stop smoking while using but pt may lapse and continue to use active PUD <2 weeks since MI, serious arrhythmias or angina pregnancy/breastfeeding legally, CANNOT sell to <21yo gum: TMJ lozenge MINT: soy allergy/hypersensitivity

Answer 224

red to orange color of urine and feces and staining of contacts and clothing, headache, hemolytic anemia, methemoglobinemia CAUTION in G6PD deficiency - may lead to hemolytic anemia renal insufficiency

Answer 225

diarrhea, flatulence, nausea, stomach cramps, swollen abdomen prolonged/frequent/excessive use may lead to electrolyte imbalance known or suspected bowel obstruction

Answer 226

abnormal taste in mouth, diarrhea, stomach cramps, hepatotoxicity none concomitant use of mineral oil intestinal obstruction acute abdominal pain N/V

Answer 227

stomach cramps, diarrhea none appendicitis intestinal obstruction gastroenteritis

Answer 228

abnormal electrolytes, stomach cramps, diarrhea none none

Answer 229

stomach cramps, diarrhea, flatulence CAUTION in phenylketonuria - some have phenylalanine none

Answer 230

stomach cramps, diarrhea, flatulence, borborygmus (stomach growling/rumbling) AVOID in pt that have difficulty swallowing CAUTION in phenylketonuria - some products have phenylalanine none

Answer 231

burning, irritation, pruritis none none

Answer 232

sedation use CAUTION in pt w/ BPH, asthma, and glaucoma given anticholinergic effects use CAUTION in elderly (65+ yo) d/t these effects and sedation N/A

Answer 233

sedation use CAUTION in pt /w BPH, asthma, and glaucoma given anticholinergic effects use CAUTION in elderly (65+ yo) d/t these effects and sedation N/A

Answer 234

fecal discoloration, tongue discoloration, tinnitus none hypersensitivity to salicylates ulcer/bleeding problems children <12yo children and teens recovering from chicken-pox or flu-like sx breastfeeding pregnant

Answer 235

constipation, abdominal pain, dizziness Torsade's, cardiac arrest, and death d/t high doses bloody/black stools febrile invasive gut bacterial infections antibiotic-associated diarrhea (C. diff)

Answer 236

acne, application site reactions, pruritis, dry skin for use on lips/face ONLY none

Answer 237

redness, irritation AVIOD contact w/ eyes recent ear surgery or tubes ear drainage/discharge/pain eardrum perforation age <3yo

Answer 238

headache, burning sensation in eyes AVOID in children <2yo none

Answer 239

dry skin, burning sensation/pruritis/stinging at site of administration, headache AVOID in infected, open or cracked lesion none

Answer 240

redness, scaling, dryness, itching, burning - improves after 1st month AVOID contact w/ eyes, lips, mouth, nose scrapes cuts photosensitivity none

Answer 241

none none none

Answer 242

flushing, headache, hepatotoxicity, gout, HYPERglycemia INC bleeding risk, fasting blood sugars, uric acid levels unstable angina active liver disease PUD arterial hemorrhage

Answer 243

irritation, burning, itching/dryness none none

Answer 244

nasal irritation and burning, headache, pharyngitis, epistaxis, taste perversion, glaucoma, pneumonia, secondary HYPOcortisolism, osteoporosis none none

Answer 245

application site reactions (e.g. blistering, bruising, burning sensation, etc) have been reported, interruption of tx may be necessary INC risk of systemic absorption associated w/ irritated or broken skin application of external heat sources a covered application site large doses large treatment areas none

Answer 246

skin irritation and potential systemic toxicity, syn sensitivity (use sunscreen SPF 15+), peeling none hypersensitivity to aspirin children/teens - recovering from chicken pox/flu r/o Reye syndrome

Answer 247

bleaching, photosensitivity, dermatological SE (peeling, drying of skin, erythema, scaling, itching, swelling) none none

Answer 248

constipation, flatulence, swollen abdomen, nephrolithiasis none HYPERcalcemia

Answer 249

burning sensation, pruritis none none

Answer 250

burning sensation, pruritis, blistering, edema, erythema none none

Answer 251

UTI, genital mycotic infections, euglycemia DKA, HYPOtension, INC urinary frequency hx of genitourinary infections hx of lower-limb amputations dialysis

Answer 252

UTI, genital mycotic infections, euglycemic DKA, HYPOtension, INC urinary frequency hx of genitourinary infections dialysis

Answer 253

UTI, genital mycotic infections, euglycemic DKA, HYPOtension, INC urinary frequency hx of genitourinary infections dialysis

Answer 254

N/V/D, worsening of diabetic retinopathy, pancreatitis risk of medullary thyroid carcinoma, pancreatitis, severe GI disease multiple endocrine neoplasia type 2 personal or family hx of medullary thyroid carcinoma

Answer 255

N/V/D, worsening of diabetic retinopathy, pancreatitis risk of medullary thyroid carcinoma, pancreatitis, severe GI disease multiple endocrine neoplasia type 2 personal or family hx of medullary thyroid carcinoma

Answer 256

HYPOglycemia elderly pt d/t INC risk of HYPOglycemia (BEERs) G6PD deficiency none

Answer 257

HYPOglycemia elderly pt d/t INC risk of HYPOglycemia (BEERs) G6PD deficiency none

Answer 258

d/t excessive dosing: palpitations, nausea, diarrhea, insomnia NOT indicated for weight lot new or worsening cardiac disease elderly pt acute MI nontoxic diffuse goiter or nodular thyroid disease uncorrected adrenal insufficiency

Answer 259

diarrhea, headache, arthralgia none none

Answer 260

N/V/D, worsening of diabetic retinopathy, pancreatitis risk of medullary thyroid carcinoma pancreatitis severe GI disease multiple endocrine neoplasia type 2 personal or family hx of medullary thyroid carcinoma

Answer 261

vitamin B12 deficiency, diarrhea, lactic acidosis INC risk of lactic acidosis in pt w/ renal or hepatic impairment hypoxic states receiving IV contrast severe GI disease acute or chronic metabolic acidosis severe renal impairment (eGFR <30)

Answer 262

edema, weight gain, hepatotoxicity CHF elderly pt (BEERs) bladder cancer hx of fractures NYHA Class 3 or 4 HF

Answer 263

rash, goiter, HYPOthyroidism pregnancy none

Answer 264

HYPOglycemia elderly pt d/t INC risk of HYPOglycemia concomitant therapy w/ gemfibrozil

Answer 265

dehydration, N/V/D, worsening of diabetic retinopathy, pancreatitis risk of medullary thyroid carcinoma pancreatitis severe GI disease multiple endocrine neoplasia type 2 personal or family hx of medullary thyroid carcinoma

Answer 266

diarrhea, headache, peripheral edema, arthralgia pt w/ HF none

Answer 267

diarrhea, headache, arthralgia none none

Answer 268

d/t excessive dosing: palpitations, nausea, diarrhea, insomnia NOT indicated for weight loss new or worsening cardiac disease elderly pt acute MI nontoxic diffuse goiter or nodular thyroid disease uncorrected adrenal insufficiency

Answer 269

HYPOglycemia, injection site reactions, weight gain elderly pt d/t INC risk of HYPOglycemia (BEERs) none

Answer 270

HYPOglycemia, injection site reactions, weight gain elderly pt d/t INC risk of HYPOglycemia none