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Top 200 Pharmacy > Top 200 - Warnings and Contraindications > Flashcards

Top 200 - Warnings and Contraindications Flashcards

1
Q

Adderall ®

A

BBW: potential for abuse/misuse

Avoid use in patients with severe cardiac disease

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2
Q

adenosine

A

Contraindicated in AV block, sick sinus syndrome, bradycardia, or asthma

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3
Q

albuterol (inhalation)

A

Contraindicated in severe hypersensitivity to milk

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4
Q

alendronate

A

Contraindicated in hypocalcemia and esophageal abnormalities

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5
Q

benzodiazepines

A

BBW: risk for dependence and withdrawal

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6
Q

alteplase tPa

A

Contraindicated in active internal bleeding

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7
Q

amiodarone

A

BBW: increased risk of pulmonary toxicity, hepatotoxicity, and heart block

Can cause sun sensitivity and QTc prolongation.

Can increase INR if taken with warfarin.

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8
Q

amitriptyline

A

BBW: increased risk of suicidality in younger patients.

Contraindicated in MAOi use within 14 days

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9
Q

amlodipine

A

When used with simvastatin, max simvastatin dose is 20 mg daily

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10
Q

amoxicillin

A

Can increase INR when used with warfarin

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11
Q

apixaban

A

BBW: premature discontinuation increases risk for thrombotic events.

Avoid concomitant use with CYP3A4 inducers.

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12
Q

beta blockers

A

Abrupt discontinuation can cause rebound HTN.

Contraindicated in acute decompensated heart failure, severe sinus bradycardia, sick sinus syndrome, bronchial asthma

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13
Q

atomoxetine

A

BBW: increased risk of suicidality in younger patients.

Contraindicated in MAOi use within 14 days and severe cardiac disease

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14
Q

azithromycin

A

QTc prolongation.

Can increase INR when used with warfarin

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15
Q

baclofen

A

BBW: abrupt discontinuation can cause CNS effects, muscle rigidity, and death

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16
Q

inhaled corticosteroids

A

Rinse mouth after use due to risk of oral thrush

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17
Q

bupropion

A

BBW: increased risk of suicidality in younger patients.

Contraindicated in seizure disorders, eating disorders, anxiety, and MAOi use within 14 days

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18
Q

buspirone

A

Contraindicated in MAOi use within 14 days

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19
Q

carbamazepine

A

BBW: life-threatening skin reactions like SJS, DRESS, and TEN

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20
Q

carbidopa and levodopa

A

Contraindicated in MAOi use within 14 days, narrow angle glaucoma

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21
Q

cefdinir

A

Can cause red discoloration of stool.

Space antacids and iron by 2 hours.

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22
Q

cephalexin

A

Can increase INR when used with warfarin

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23
Q

ciprofloxacin

A

BBW: increased risk of tendon rupture

QTc prolongation.

Space dose from antacids. Can increase INR when used with warfarin.

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24
Q

SSRIs

A

BBW: increased risk of suicidality in younger patients

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25
clindamycin
administer with full glass of water. CYP3A4 substrate
26
clonidine
abrupt discontinuation can cause rebound hypertension
27
clopidogrel
BBW: diminished effect if patient has 2 loss-of-function CYP2C19 alleles PPIs diminish effectiveness of clopidogrel.
28
diazepam
BBW: risk for dependence and withdrawal
29
digoxin
Contraindicated in ventricular fibrillation
30
diltiazem
Contraindicated in bradycardia, sick sinus syndrome, decompensated heart failure, acute MI, and pulmonary congestion.
31
divalproex
BBW: hepatotoxicity, pancreatitis. Teratogenic med.
32
doxycycline hyclate
Administer with full glass of water and remain upright for 2 hours. Antacids, calcium, and multivitamins can decrease absorption. Can increase INR with warfarin.
33
dulaglutide
BBW: risk of thyroid C-cell tumors. Contraindicated in history of medullary thyroid carcinoma and MEN-2
34
empagliflozin 
Contraindicated in GFR < 45 and dialysis. Increased risk of DKA
35
enoxaparin
BBW: risk of spinal hematoma. Contraindicated in heparin allergy, HIT, and active major bleeding
36
estradiol
Contraindicated in pregnancy, history of breast cancer, thromboembolism, or stroke/MI
37
famotidine
QTc prolongation. May decrease absorption of drugs that require acidic environment
38
fenofibrate 
Contraindicated in liver disease, kidney disease, and breastfeeding
39
finasteride
BBW: females of childbearing age should not touch crushed or broken tablets
40
fluconazole
QTc prolongation. Significantly increases INR when used with warfarin. Strong CYP2C19 inhibitor.
41
gemfibrozil
Increased risk of adverse effects when combined with statins or ezetimibe. Contraindicated in liver disease, kidney disease, and breastfeeding
42
gentamicin
BBW: neurotoxicity, nephrotoxicity, fetal toxicity.
43
Genvoya ®
BBW: acute exacerbation of Hepatitis B. Contraindicated in concomitant use with CYP3A4 substrates
44
glimepiride
Administer before first meal daily. Contraindicated in Type 1 diabetes and DKA
45
glipizide
Administer ER tablet with first meal of day. Administer IR tablet 30 minutes before a meal. Contraindicated in Type 1 diabetes and DKA
46
hydralazine
Contraindicated in CAD and mitral valve rheumatic disease
47
hydrochlorothiazide
Contraindicated in GFR < 10
48
icosapent ethyl  
Take with food
49
isosorbide mononitrate
Do not use nitrates and PDE5 inhibitors together
50
lamotrigine
BBW: life-threatening skin reactions like SJS, DRESS, and TEN
51
levofloxacin
QTc prolongation. Space dose from antacids. Can increase INR when used with warfarin. BBW: increased risk of tendon rupture
52
levothyroxine 
Take the same way every day with regard to meals. BBW: should not be used for weight loss
53
lidocaine (transdermal)
Contraindicated in severe heart block
54
ACE inhibitors
Can cause persistant dry cough. BBW: fetal toxicity. Contraindicated in angioedema
55
lithium
BBW: required serum monitoring every week until stable, then every 3-6 months. Contraindicated in severe cardiovascular or renal disease, dehydration, concurrent use with diuretics
56
Progesterone
BBW: reduced bone density, increased risk of breast cancer
57
metformin 
BBW: lactic acidosis. Contraindicated if GFR < 30
58
methadone
BBW: increased risk of respiratory depression and QTc prolongation
59
metoclopramide
Administer 30 minutes before meals. QTc prolongation
60
metronidazole
Avoid alcohol during treatment and for 3 days after. Can increase INR when used with warfarin. QTc prolongation
61
mirtazapine
BBW: increased risk of suicidality in younger patients. Contraindicated in use of MAOis within 14 days
62
montelukast
Give dose in evening. BBW: serious psychiatric events reported with use
63
niacin 
Take with food. Contraindicated in liver disease, active peptic ulcer, and arterial hemorrhage
64
nifedipine
Contraindicated in STEMI patients
65
nitroglycerin
Do not use nitrates and PDE5 inhibitors together
66
omeprazole/esomeprazole
Administer 1 hour before breakfast. Capsule contents can be opened and sprinkled on applesauce. May decrease absorption of drugs that require acidic environment. Can diminish antiplatelet effect of clopidogrel
67
ondansetron
QTc prolongation
68
Ortho-Cyclen®, Sprintec®
BBW: cigarette smoking increases risk of cardiovascular events
69
oxybutynin
Contraindicated in narrow angle glaucoma, urinary retention, severely decreased GI motility
70
pantoprazole
Administer whole capsule without regard to food. May decrease absorption of drugs that require acidic environment. May diminish antiplatelet effect of clopidogrel
71
phentermine
Avoid late evening administration. Contraindicated in pregnancy, CVD, SUD, hyperthyroidism, and glaucoma
72
pioglitazone
Dose < 15mg daily when used with gemfibrozil. May need dose reduction if taking clopidogrel. BBW: increased risk of heart failure exacerbation
73
prednisone
Administer after food to decrease stomach upset
74
rivaroxaban
Doses >10 mg should be taken with food. Avoid concomitant use with CYP3A4 inducers. BBW: premature discontinuation increases risk for thrombotic events. Contraindicated if GFR < 30
75
sacubitril and valsartan
BBW: fetal toxicity. Contraindicated in pregnancy, angioedema, concomitant use of aliskiren or ACE inhibitors
76
sertraline 
BBW: increased risk of suicidality in younger patients
77
sildenafil
Do not use nitrates and PDE5 inhibitors together. When used for ED, adminster 30 min to 4 hours before sexual activity
78
simvastatin
Can cause muscle pain or dark colored urine. When used with amlodipine or amiodarone, maximum dose of 20 mg daily
79
spironolactone
Contrainidicated in hyperkalemia, concomitant use with eplerenone
80
sucralfate
administer on empty stomach. Do not give multivitamins or cation-based antacids within 30 minutes
81
sulfamethoxazole and trimethoprim
administer with full glass of water. Can cause sun sensitivity. Significantly increases INR when used with warfarin
82
sumatriptan
Contraindicated ischemic heart disease, history of strokes, uncontrolled hypertension, arrhythmias
83
tadalafil
Do not use nitrates and PDE5 inhibitors together. When used PRN for ED, take 30 m inutes prior to sexual activity
84
tamsulosin
administer 30 minutes after same meal every day
85
testosterone (topical)
risk of secondary exposure if using transdermal formulations. BBW: hypertension
86
trazodone 
BBW: increased risk of suicidality in younger patients. Contraindicated in MAOi use within 14 days
87
Triumeq®
BBW: hypersensitivity reactions, acute exacerbations of Hepatitis B. Contraindicated in hepatic impairment, concomitant dofetilide, and patients with HLA-B*5701 allele
88
valacyclovir
can decrease effectiveness of live vaccines
89
ARBs
Contraindicated in concomitant use with aliskiren. BBW: fetal toxicity
90
vancomycin
BBW: fetal toxicity
91
verapamil
when used with simvastatin, max statin dose is 10 mg daily. Contraindicated in bradycardia, sick sinus syndrome, decompensated heart failure, acute MI, and pulmonary congestion.
92
Vyvanse ®
BBW: abuse potential. Contraindicated in MAOi use within 14 days
93
warfarin
Increase INR: alcohol, NSAIDs, macrolides, antifungals. Decrease INR: rifampin, leafy greens, St. John's wort
94
atypical antipsychotics
BBW: increased mortality in elderly with dementia-related psychosis

Top 200 Pharmacy (3 decks)

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