Tooth Development 2 Flashcards
What are the stages of amelogenesis?
Pre-secretory
Secretory
Maturation
What part of the tooth germ differentiate into ameloblasts?
IEE
What occurs in the pre-secretory stage of amelogenesis?
-differentiation of pre-ameloblasts (cubodial -> columnar cells)
-odontoblasts secrete pre-dentine matrix which signals for ameloblasts to start secretion
What occurs in the secretory stage of Amelogenesis?
-Fully differentiated w. Tomes process
-tomes process secrete enamel matrix
-columnar cells
-finishes when full thickness of enamel is reached
Name the enamel proteins.(4)
Amelogenin
Ameloblastin
Enamelin
Tuftelin
Describe the maturation stage of Amelogenesis.
- majority of amelogenins removed
- enzymes break down amelogenins soon after secretion of enamel matrix
- loss of tomes process
- bulk water removal -> mature enamel
- via smooth ended and ruffled ended ameloblasts
what’s the significance of the tomes process in ameloblasts?
Secreates the initial enamel matrix
How does immature enamel differ from mature enamel?
- mature enamel has:
- less water (from bulk water removal)
- more mineral content.
What’s the final stage of Amelogenesis?
- formation of hydroxyapatite crystals
- apoptosis of ameloblasts
At what stage of tooth development does the differentiation of odontoblasts occur?
Bud/cap stage
Where are odontoblasts originated?
Peripheral cells of the dental papilla
What stimulates the differentiation of odotoblasts?
Inductive signals from pre-ameloblasts
What shape are pre-odontoblasts?
Columnar
What’s the role of pre-odontoblasts?
Develops odontoblast processes
Secretes extracellular dentine matrix
Describe the maturation process of the dentine matrix.
-Calcium and phosphate ions deposited into matrix
- mineralising it
-pre dentine -> mature dentine
-formation of hydroxyapatite crystals
-odontoblast processes form dentinal tubules