Tooth Development 2 Flashcards

1
Q

What are the stages of amelogenesis?

A

Pre-secretory
Secretory
Maturation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What part of the tooth germ differentiate into ameloblasts?

A

IEE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What occurs in the pre-secretory stage of amelogenesis?

A

-differentiation of pre-ameloblasts (cubodial -> columnar cells)
-odontoblasts secrete pre-dentine matrix which signals for ameloblasts to start secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What occurs in the secretory stage of Amelogenesis?

A

-Fully differentiated w. Tomes process
-tomes process secrete enamel matrix
-columnar cells
-finishes when full thickness of enamel is reached

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name the enamel proteins.(4)

A

Amelogenin
Ameloblastin
Enamelin
Tuftelin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Describe the maturation stage of Amelogenesis.

A
  • majority of amelogenins removed
  • enzymes break down amelogenins soon after secretion of enamel matrix
  • loss of tomes process
  • bulk water removal -> mature enamel
    • via smooth ended and ruffled ended ameloblasts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what’s the significance of the tomes process in ameloblasts?

A

Secreates the initial enamel matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does immature enamel differ from mature enamel?

A
  • mature enamel has:
    • less water (from bulk water removal)
    • more mineral content.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What’s the final stage of Amelogenesis?

A
  • formation of hydroxyapatite crystals
  • apoptosis of ameloblasts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

At what stage of tooth development does the differentiation of odontoblasts occur?

A

Bud/cap stage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Where are odontoblasts originated?

A

Peripheral cells of the dental papilla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What stimulates the differentiation of odotoblasts?

A

Inductive signals from pre-ameloblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What shape are pre-odontoblasts?

A

Columnar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What’s the role of pre-odontoblasts?

A

Develops odontoblast processes
Secretes extracellular dentine matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Describe the maturation process of the dentine matrix.

A

-Calcium and phosphate ions deposited into matrix
- mineralising it
-pre dentine -> mature dentine
-formation of hydroxyapatite crystals
-odontoblast processes form dentinal tubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the types of dentine and when are they deposited?

A

Primary = in tooth development
Secondary = throughout life
Tertiary (reparative/reactionary) = in response to assault

17
Q

Compare mineralisation of dentine and enamel.

A

ENAMEL
- instantaneous

DENTINE
- lags begins

18
Q

State the similarities between Dentinogenesis and Amelogenesis. (2)

A
  • elongated columnar cells
  • both form hydroxyapatite crystals
19
Q

Where does the pulp originate from?

A

Dental papilla

20
Q

What occurs in root development?

A
  • dentine deposition ‘outlines’ pulp chamber
  • IEE and OEE fuse to form double layered HERS
  • HERS completes outline of root canals + enclose dental papilla
  • root sheath disintegrates
21
Q

What’s unique about the growing patterns of HERS?

A
  • root sheath always remains the same size
  • downgrowth/degeneration = proliferation
22
Q

Describe development of root dentine.

A
  • mesenchymal cells in dental papilla located between HERS layers differentiate into odontoblasts
  • secrete pre-dentine
  • mineralisation of dentine via deposition of hydroxyapatite
  • dentinal tubule formation (from odontoblasts processes)
23
Q

What’s the process in the development of primary cementum (acellular)?

A

-at time of tooth eruption
- extomesenchymal cells from dental follicle between layers of HERS differentiate into ‘cementoblast-like cells’
- cementoblasts secrete unmineralised cementoid + cementoblasts become embedded in it
- hydroxyapatite deposition =mineralise

24
Q

what’s the process in the development of secondary cementum (cellular)?

A
  • after tooth eruption
  • external stimuli stimulate cementoblasts to deposit secondary cementum (between cementum and PDL)
25
Q

Explain the development of the PDL.

A
  1. Cells in dental follicle differentiate into fibroblasts, cementoblats, osteoblasts, osteoclasts
  2. Dental follicle differentiates into PDL
  3. Fibroblasts synthesise collagen fibres (including Sharpey’s fibres)