Tonometry 1 Flashcards
Circulation of aqueous delivers ___ to and removes ____ from ____.
Delivers oxygen and nutrients and removes waste from posterior cornea, lens and anterior vitreous (avascular structures)
Hypotony
Very low IOP <5mmHg
Very low IOP could be due to
Post surgery wound leaks
CB disease
Low IOP can lead to (hypotony)
Corneal decompensation, macular edema, choroidal effusions, etc
Acute elevation of IOP can be due to
Acute decline in aqueous outflow
Angle closure, inflammation, neovascularization
Acute elevation of IOP can lead to
Insufficient perfusion of ONH and subsequent optic atrophy (ischemic optic neuropathy)
Chronic elevation of IOP is
Slow gradual rise of IOP, compensatory mechanisms have time to operate avoiding the symptoms of acute IOP elevation
Chronic IOP elevation is almost always a consequence of
Decreased aqueous outflow facility
Chronic elevation of IOP is usually idiopathic but may also occur secondary to
Pigment deposition, exfoliation syndrome, etc
During chronic elevation of IOP ___ arises in susceptible individuals
Optic neuropathy
IOP is important in an eye exam because of
Screen for glaucoma Future comparison in glaucoma pts Detect wound leak in post op/trauma Rule out acute glaucoma Detect drug reactions for corticosteroids Monitor glaucoma therapy
Any attempt of measuring IOP will often change it by
causing an artificial rise in pressure
Gold standard of measuring IOP due to historical reasons
Goldman
Not because its less subjected to influences
Measured IOP is influence by
Biochemical properties like corneal rigidity, thickness and hysteresis
IOP is highly variable and its measurement is subject to
Considerable error
IOP is dynamic meaning
It’s constantly changing and each reading is at best a snapshot of the IOP in that moment
A change in about 3mmHg is considered
Clinically significant, smaller changes are likely to be noise or measurement error
Time of day, cardiac cycle and body position can
Change IOP
IOP is highest at what time of the day?
Early morning
IOP is increased during what part of the cardiac cycle?
Systole
IOP increases during what body position
When position is changed from upright to recumbent
head down position
IOP changing during changing body positions is believed to be due to
Episcleral venous pressure
The variability (difference) between IOPs in the same eye during different visits is ____ than the variability of IOP of R & L eyes in one visit
Greater
What is monocular treatment trial
Since the correlations of IOP between eyes is so strong. One eyes may serve as a control when starting glaucoma medication
What is a safe IOP
There is no IOP considered safe or unsafe
Target pressure is
A presumed safe IOP that is a certain amount less than IOP at glaucoma damage has occurred
A difference of more than 3mmH is considered ___ and is a risk factor for ___
Asymmetric
Glaucoma
Prevalence of asymmetry of IOPs between eyes _____ with age.
Increases
Each additional 1mmHg increase of IPA asymmetry between eyes is associated with _% increase of ____
21% of risk for development of glaucoma
Ocular pulse amplitude means _____. Which results from ___.
IOP increase during systole and decreases during diastole. Results from volume change in the blood entering the eye that occurs during systole
Normal ocular pulse amplitude is
3mmHg with <0.5 mmHg difference between eyes
Because of OPA, ____ is required to record and compensate for the pulse
Continuous Tonometry over several pulse cycles
During higher IOP, OPA usually
Increases
IOP will increase in __ position, largely due to elevation of ____
Supine
Elevation of episcleral venous pressure
IOP will increase ___ when changing from standing/ sitting straigh to supine position
2-4 mmHg
IOP will _____ when the body is upside down
Increase (2-3X)
Even though aqueous production decreases during night time, there is decreased outflow and increased episcleral venous pressure counteracting and causing
Overall increase in nocturnal IOP
Pressure is usually highest during __ and lowest in ___.
3-5 am
Lowest at 7-9 PM evening
The observed nocturnal rise in IOP is part of the reason why IOP is elevated during
IOP elevation while laying down
Diurnal IOP variation can still occur even in absence of
Postural effect
Diurnal IOP variation is due to various physiological reasons including
Ocular perfusion pressures, hormones, outflow facility during sleep
Large diurnal variation is suggestive of
Glaucoma