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tolerance doses Flashcards

1
Q

what is the tolerance dose for the skin

A

55Gy

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2
Q

Dry Desquamation

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • acute
  • 50Gy, 25#
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3
Q

Moist desquamation

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • acute
  • 60Gy, 30 fractions
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4
Q

Hair loss

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • acute
  • 20Gy, 10#
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5
Q

Atrophy, telangectasia, fragility, induration, ulcer

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • Late
  • 55Gy, 25#
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6
Q

what is the tolerance dose to the lens of the eye

A

5Gy

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7
Q

Xeropthalmia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Lens of the eye
  • Sub-acute / late
  • 30Gy in 30#

Xeropthalmia is when the eye is unable to produce tears.

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8
Q

Decreased visual activity / blindness

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lens of the eye
  • Late
  • 50Gy, 25#
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9
Q

Cataract

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lens of the eye
  • late
  • 10Gy, 5#
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10
Q

what is the tolerance dose of the ears and tongue

A

60Gy

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11
Q

otitis media

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Ears and Tongue
  • acute
  • 30Gy in 15#

otitis media is an ear infection

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12
Q

Loss of taste

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • ears and tongue
  • acute / sub-acute
  • 30Gy, 15#
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13
Q

Deafness

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • ears and tongue
  • Late
  • <60Gy, 30#
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14
Q

what is the maximum dose for the mouth, salivary glands

A

60Gy

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15
Q

decreased saliva

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • acute / sub-acute
  • 20Gy, 10#
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16
Q

Acute painful salitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • acute
  • 10Gy, 5#
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17
Q

Painful mucositis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • acute
  • 40Gy, 20#
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18
Q

Permanent xerostomia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • late
  • 50Gy, 25#

Permanent xerostomia - no saliva present in the salivary glands

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19
Q

Mucosal ulcer, severe fibrosis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • Late
  • 60Gy, 30#
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20
Q

what is the tolerance dose of the larynx

A

65Gy

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21
Q

Persistent oedema, cartilage necrosis.

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Larynx
  • sub-acute / late
  • 65Gy, 33#
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22
Q

what is the tolerance dose of the lung

A

30Gy (45Gy partial volume)

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23
Q

Pneumonitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lung
  • sub-acute
  • 20Gy, 10#
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24
Q

Pulmonary fibrosis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Lung
  • Late
  • 30Gy
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25
Q

What is the tolerance dose to the heart

A

40Gy

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26
Q

pancarditis, pericarditis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • heart
  • sub-acute
  • 40Gy, 20#
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27
Q

pericardial stricture/effusion, mycardiopathy

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • heart
  • late
  • 45Gy, 23#
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28
Q

what is the tolerance dose of the stomach and bowel

A

45Gy

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29
Q

Procitis with tenesmus

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • stomach and bowel
  • acute
  • 40Gy in 20#

procitis with tenesmus - inflamation and damage of the bowel

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30
Q

Diarrhoea

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • stomach and bowel
  • acute
  • 20Gy in 10#
31
Q

Procitis with bleeding

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • stomach and bowel
  • acute
  • 50Gy in 25#
32
Q

strictures, ulcers, performation, fistulas

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • stomach and bowel
  • late
  • 45Gy in 23#
33
Q

what is the tolerance dose of the rectum

A

40Gy or 60Gy with limited volume

34
Q

what is the tolerance dose of the oesophagus

35
Q

oesophagitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • oesophagus
  • acute
  • 30Gy in 15#
36
Q

what is the tolerance dose of the liver

37
Q

Hepatitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Liver
  • Sub-acute
  • 25Gy in 12#

Hepatitis - inflammation of the liver.

38
Q

Liver failure, ascites

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Liver
  • Late
  • 35Gy in 18#

Ascites - build up of fluid in the abdomen

39
Q

What is the tolerance dose of the kidneys

A

1/3 each kidney 40Gy

40
Q

Nephritis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • kidneys
  • sub-acute
  • 20Gy in 10#

Nephritis - inflammation of the kidneys

42
Q

Hypertension

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • kidneys
  • sub-acute / late
  • > 20Gy in 10#
43
Q

stricture with obstruction

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • kidneys specifically the ureters
  • late
  • 75Gy in 38#

stricture - narrowing of the urethra

44
Q

What is the tolerance dose of the bladder

45
Q

cystitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • bladder
  • acute
  • 40Gy in 20#

urinary tract infection

46
Q

chronic cystitis, ulcer, contracture

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • bladder
  • late
  • 65Gy in 33#

contracture - shortening of muscle, tendons, skin etc…

47
Q

Impotence

  • What area does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • prosate
  • sub-acute / late
  • 60Gy in 30#
48
Q

Ulcer, Fistula

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Vagina
  • Late
  • 90Gy in 45#
49
Q

Necrosis and perforation

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • uterus
  • late
  • > 100Gy in 50#
50
Q

Hypopituitarism

  • What gland does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Pituitary gland
  • Late
  • 45Gy in 23#

Hypoptituitarism - the pituitary gland does not make enough hormones.

51
Q

Hypothyroidism

  • What gland does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • thyroid gland
  • late
  • 45Gy in 23#
52
Q

Hypoadrenalism

  • What gland does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • adrenal glands
  • late
  • 60Gy in 30#
53
Q

What is the tolerance dose of the gonads

54
Q

Sterility, temporary amenorrhoea

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • gonads
  • acute / sub-acute
  • 3Gy

Amenorrhoea = absence of menstruation

55
Q

sterility, permanent amenorrhoea

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • gonads
  • late
  • 15Gy
56
Q

What is the tolerance dose of the brain (including optic nerve)

57
Q

Necrosis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Brain (including optic nerve)
  • late
  • 55Gy in 25#
58
Q

What is the tolerance of the brain stem

59
Q

what is the tolerance dose of the spinal cord

A

44Gy in 10cm length

60
Q

L’Hermitte’s syndrome

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • spinal cord
  • sub-acute
  • 45Gy in 23#
61
Q

Transverse Myelitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Spinal cord
  • Late
  • 50Gy in 25#

Transverse myelitis - inflammation of the spinal cord

62
Q

Lymphoedema

  • What system does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lympthics system
  • Late
  • 50Gy in 25#
63
Q

Atrophy and Induration

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Breast
  • Late
  • 50Gy in 25#
64
Q

Atrophy

  • What does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • muscles
  • Late
  • > 100Gy in 50#
65
Q

Necrosis and fracture

  • What does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • bone and cartilage
  • Late
  • 60Gy in 30#
66
Q

What is the tolerance dose of bone and cartilage

67
Q

Leukopaenia, thrombocytopenia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • bone marrow
  • Acute
  • Dependent on location, site and dose
68
Q

immunodeficiency

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • bone marrow
  • acute / sub-acute
  • dependent on location, site and dose
69
Q

Marrow hyperplasia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Bone marrow
  • Late
  • 20Gy in 10#

Proliferation of hyperplastic haematopoietic marrow.

70
Q

Leukaemia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Bone marrow
  • late
  • dependent on location, site and dose
71
Q

Foetal death

  • What does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • foetus
  • Acute / Sub-acute
  • 2-2.5Gy
72
Q

when do acute side effects typically occur

A

occur during radiotherapy or a couple of weeks after.

73
Q

when do sub-acute side effects typically occur

A

occur during 2-6 months after radiotherapy

74
Q

when do late side effects typically occur

A

occur several months to years after radiotherapy

Tolerance doses radiotherapy (1 decks)

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